Further experience with indomethacin in the treatment of rheumatic disorders.

Thompson, M.; Percy, J. S.

doi:10.1136/bmj.1.5479.80

Cited by 41 publications

(18 citation statements)

References 4 publications

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“…The present study describes the designing and synthesis of a small molecule, tryptamine-gallic acid hybrid (SEGA (3a)), which prevents NSAID-induced mitochondrial pathology, apoptosis, and gastropathy by blocking MOS through scavenging of intramitochondrial O 2 . and free iron and correcting mitochondrial dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…2 are the most popular drugs commonly used throughout the world for the treatment of pain, inflammation, rheumatic disorders, and osteoarthritis (1,2). Approximately 30 million patients consume NSAIDs on a daily basis (1).…”

Section: Nsaidsmentioning

confidence: 99%

“…4C), which are the markers for MOS. SEGA (3a) Corrects Indomethacin-induced Mitochondrial Dysfunction-Because SEGA (3a) scavenges intramitochondrial O 2 . , chelates intramitochondrial free iron, and prevents MOS, we were interested to find out whether SEGA (3a) could prevent mitochondrial pathology or dysfunction.…”

Section: Sega (3a) Prevents Indomethacin (Nsaid)-inducedmentioning

confidence: 99%

“…Quantitation of SEGA (3a) Entering Mitochondria-Because SEGA (3a) scavenged intramitochondrial O 2 . , chelated intramitochondrial iron, and prevented MOS, we were interested in quantitating how much of the administered SEGA (3a) entered the mitochondria under in vivo conditions.…”

Section: Sega (3a) Prevents Activation Of Mitochondrial Pathway Of Apmentioning

confidence: 99%

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Tryptamine-Gallic Acid Hybrid Prevents Non-steroidal Anti-inflammatory Drug-induced Gastropathy

Pal

Dey

Alam

et al. 2012

Journal of Biological Chemistry

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Background: Non-steroidal anti-inflammatory drugs (NSAIDs) induce gastropathy by promoting mitochondrial pathology, oxidative stress, and apoptosis in gastric mucosal cells. Results: We have synthesized SEGA (3a), a tryptamine-gallic acid hybrid, which prevents NSAID-induced gastropathy by preventing mitochondrial oxidative stress, dysfunction, and apoptosis. Conclusion: SEGA (3a) bears an immense therapeutic potential against NSAID-induced gastropathy. Significance: This novel molecule is a significant addition in the discovery of gastroprotective drugs.

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Section: Discussionmentioning

confidence: 99%

Section: Nsaidsmentioning

confidence: 99%

Section: Sega (3a) Prevents Indomethacin (Nsaid)-inducedmentioning

confidence: 99%

Section: Sega (3a) Prevents Activation Of Mitochondrial Pathway Of Apmentioning

confidence: 99%

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Tryptamine-Gallic Acid Hybrid Prevents Non-steroidal Anti-inflammatory Drug-induced Gastropathy

Pal

Dey

Alam

et al. 2012

Journal of Biological Chemistry

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“…İndometazin durdurulduğu andan itibaren üç aylık periyodda halüsinasyonlar görülmemiştir. 44 Bir olgu bildiriminde, paranoit delüzyonlar ve halüsinasyonlar geliştiren 58 yaşındaki bir erkek hastanın indometazin aldığı bildirilmiştir. Ayrıca, bu etkiler sadece gece uyanma sırasında gerçekleşmiştir.…”

Section: İndometazi̇nunclassified