Further experience in treating patients with hepatocellular carcinoma in Uganda

Olweny, Charles L. M.; Katongole‐Mbidde, Edward; Bahendeka, Silver; Otim, David; Mugerwa, J. W.; Kyalwazi, S. K.

doi:10.1002/1097-0142(19801215)46:12<2717::aid-cncr2820461230>3.0.co;2-t

Cited by 75 publications

(6 citation statements)

References 13 publications

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“…Primary hepatocellular carcinoma in Uganda occurs in young patients 5,6 . In our study the youngest patient was 15 years old.…”

Section: Discussionmentioning

confidence: 99%

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Hepatitis B virus and HIV infection among patients with primary hepatocellular carcinoma in Kampala, Uganda

Ocama¹,

Opio²,

Kagimu³

et al. 2011

Af Hlth Sci

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Background: Hepatitis B virus (HBV) is the commonest cause of primary hepatocellular (PHC) carcinoma worldwide. Coinfection with the HIV leads to more rapid progression of liver disease. Objectives: We described prevalence of HBV and HIV among patients with PHC admitted to Mulago Hospital, Kampala, Uganda. Methods:We assessed all patients admitted to the gastrointestinal service of Mulago hospital with a diagnosis of PHC for HBV and HIV infection. Results: From March to June 2008, we recruited 15 patients. Nine (60%) were male; the overall median age was 32 years (IQR 15 -67), with median ages for male and female 33 and 36 years respectively. Alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and AFP were all elevated with median values of 57.5 IU/L, 222 IU/L, 392 IU/L and 362 ng/ml respectively (IQR 14-145, 49-393, 165-1294 and 7-480). Eight (53%) patients were from North and Northeastern Uganda. The HBsAg was reactive in 13(87%) patients and HIV in 3(20%), all of whom were also co-infected with HBV. Conclusion: There is high prevalence of HBV and HBV/HIV co-infection among patients with PHC in Uganda with high mortality. Reduction in incidence and mortality due to PHC in Uganda will require urgent large scale HBV vaccination.

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“…Primary hepatocellular carcinoma in Uganda occurs in young patients 5,6 . In our study the youngest patient was 15 years old.…”

Section: Discussionmentioning

confidence: 99%

“…In Uganda earlier studies on PHC before the HIV epidemic showed high prevalence rates of HBV (60-80%) among patients with PHC [4][5][6][7] . Indeed analysis from Kampala cancer registry indicated an increase of PHC among women over the periods 1960-1980 and 1991 to 2005.…”

Section: Introductionmentioning

confidence: 99%

Hepatitis B virus and HIV infection among patients with primary hepatocellular carcinoma in Kampala, Uganda

Ocama¹,

Opio²,

Kagimu³

et al. 2011

Af Hlth Sci

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“…Following the initial report from Olweny in 1975, response rates between 10% and 25% have been reported (Vogel et al 1977;Falkson et al 1978;Johnson et al 1978;Chan et al 1980;Olweny et al 1980). Doxorubicin is an anthracycline antibiotic with a wide spectrum of antineoplastic activity.…”

Section: Introductionmentioning

confidence: 99%

Effects of doxorubicin, mitomycin C, and ethanol on Hep-G2 cells in vitro

Castañeda¹,

Kinne²

1999

Journal of Cancer Research and Clinical Oncology

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There are conflicting results for experiments aimed at determining whether anticancer drug therapy of human hepatocellular carcinoma prolongs the survival rate effectively. The purpose of this study was to assess the effect of low concentrations of doxorubicin, mitomycin C, and ethanol on cell replication (cell number and proliferation), and cell apoptosis of cultured human hepatocellular carcinoma (Hep-G2) cells. After 1 day of exposure doxorubicin inhibited cell replication initially by 72%, but a partial recovery of the cell number was observed. Mitomycin C inhibited to the same extent but without recovery. Ethanol reduced the cell number even further, the maximum inhibition (12 days after exposure) being 96.4%. After 3 days of exposure all three agents stopped cell replication at a level of 2%-4% of the control (P < 0.001). Cell apoptosis was activated most strikingly by mitomycin C (5 microg/ml) after 1 day of exposure and by ethanol (150 microl/ml) after 3 days of exposure. Two-way repeated-measures analysis of variance showed statistically significant differences, with ethanol being the most significant followed by mitomycin C doxorubicin, and the control (P < 0.01). Thus, a low dose of ethanol combined with an exposure time of up to 3 days appears to be an effective regimen to control growth of human hepatocellular carcinoma cells in vitro. The strong induction of apoptosis by ethanol might be of additional benefit for a local application in vivo.

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“…The commonest site is the nails (1-4). It can also develop on the palms and soles (5,6), tongue (6,7), buccal mucosa (5) or face (9). Total body pigmentation has also been reported (4).…”

Section: Discussionmentioning

confidence: 99%