Further evidences for sleep instability and impaired spindle-delta dynamics in schizophrenia: a whole-night polysomnography study with neuroloop-gain and sleep-cycle analysis

Sasidharan, Arun; Kumar, Sunil; Nair, A. K.; Lukose, Ammu; Vrinda, Marigowda; John, John P.; Kutty, Bindu M.

doi:10.1016/j.sleep.2017.02.009

Cited by 23 publications

(11 citation statements)

References 54 publications

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“…It is plausible that genetic variants for schizophrenia act differently in healthy adolescent participants regarding sleep spindle activity than in schizophrenia patients. Another possibility is that the reduced stage two of NREM sleep seen in schizophrenia patients as compared with healthy controls (Sasidharan et al, ) contributes to reduced sleep spindle activity in schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

Genetic risk factors for schizophrenia associate with sleep spindle activity in healthy adolescents

Merikanto

Utge

Lahti

et al. 2018

Journal of Sleep Research

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Schizophrenia has been associated with disturbed sleep, even before the onset of the disorder, and also in non-schizophrenic first-order relatives. This may point to an underlying genetic influence. Here we examine whether weighted polygenic risk scores (PRS) for schizophrenia are associated with sleep spindle activity in healthy adolescents. Our sample comes from a community-based cohort of 157 non-schizophrenic adolescents (57% girls) having both genetic data and an overnight sleep EEG measurement available. Based on a recent genome-wide association study, we calculated PRS for schizophrenia across the whole genome. We also calculated PRS for the CACNA1l gene region, which has been associated with both schizophrenia and sleep spindle formation. We performed an overnight sleep EEG at the homes of the participants. Stage two sleep spindles were detected using an automated algorithm. Sleep spindle amplitude, duration, intensity and density were measured separately for central and frontal derivations and for fast (13-16 Hz) and slow (10-13 Hz) spindles. PRS for schizophrenia was associated with higher fast spindle amplitude (p = 0.04), density (p = 0.006) and intensity (p = 0.04) at the central derivation, and PRS in the CACNA1l region associated with higher slow spindle amplitude (p = 0.01), duration (p = 0.03) and intensity (p = 0.002) at the central derivation. A positive association between genetic variants for schizophrenia and sleep spindle activity among healthy adolescents supports a view that sleep spindles and schizophrenia share similar genetic pathways. This study suggests that altered sleep spindle activity might serve as an endophenotype of schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Genetic risk factors for schizophrenia associate with sleep spindle activity in healthy adolescents

Merikanto

Utge

Lahti

et al. 2018

Journal of Sleep Research

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“…18 The major findings in sleep architecture could be aligned, such as long sleep-onset latency, increased intermittent-awakenings, decreased total sleep time, and poor sleep efficiency. 215 Moreover, reductions in REM latency, REM density, and duration of non-REM Stage 4 are other alterations in micro-sleep architecture. 17,18,[216][217][218] Sleep disturbances are also important to predict increased suicide attempts in patients with schizophrenia.…”

Section: Schizophreniamentioning

confidence: 99%

Chronobiology Revisited in Psychiatric Disorders: From a Translational Perspective

Kırlıoğlu

Balcıoğlu

2020

Psychiatry Investig

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Objective Several lines of evidence support a relationship between circadian rhythms disruption in the onset, course, and maintenance of mental disorders. Despite the study of circadian phenotypes promising a decent understanding of the pathophysiologic or etiologic mechanisms of psychiatric entities, several questions still need to be addressed. In this review, we aimed to synthesize the literature investigating chronobiologic theories and their associations with psychiatric entities.Methods The Medline, Embase, PsycInfo, and Scopus databases were comprehensively and systematically searched and articles published between January 1990 and October 2019 were reviewed. Different combinations of the relevant keywords were polled. We first introduced molecular elements and mechanisms of the circadian system to promote a better understanding of the chronobiologic implications of mental disorders. Then, we comprehensively and systematically reviewed circadian system studies in mood disorders, schizophrenia, and anxiety disorders.Results Although subject characteristics and study designs vary across studies, current research has demonstrated that circadian pathologies, including genetic and neurohumoral alterations, represent the neural substrates of the pathophysiology of many psychiatric disorders. Impaired HPA-axis function-related glucocorticoid rhythm and disrupted melatonin homeostasis have been prominently demonstrated in schizophrenia and other psychotic disorders, while alterations of molecular expressions of circadian rhythm genes including <i>CLOCK, PER</i>, and <i>CRY</i> have been reported to be involved in the pathogenesis of mood disorders.Conclusion Further translational work is needed to identify the causal relationship between circadian physiology abnormalities and mental disorders and related psychopathology, and to develop sound pharmacologic interventions.

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“…There is evidence on the impairment of sleep spindles in schizophrenic patients that are in line with their altered brain pathophysiology (Ferrarelli et al, 2007). Both, a reduction of sleep spindle number and amplitude have further been reported in schizophrenics in which the underlying impaired thalamocortical communication and the link to concomitant memory impairments are well established (Ferrarelli et al, 2007, Ferrarelli and Tononi, 2017, Sasidharan et al, 2017, Schilling et al, 2017 and are in line with abnormal perceptions typical for schizophrenia (Vukadinovic, 2011). These findings in schizophrenia patients suggest a vital role of sleep spindles in memory consolidation processes impaired in such diseases.…”

Section: Sleep Spindles and Psychiatric Disordersmentioning

confidence: 83%

Sleep spindles and cognition in depression

Bovy¹,

Dresler²,

Weber³

2017

Preprint

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Further evidences for sleep instability and impaired spindle-delta dynamics in schizophrenia: a whole-night polysomnography study with neuroloop-gain and sleep-cycle analysis

Cited by 23 publications

References 54 publications

Genetic risk factors for schizophrenia associate with sleep spindle activity in healthy adolescents

Genetic risk factors for schizophrenia associate with sleep spindle activity in healthy adolescents

Chronobiology Revisited in Psychiatric Disorders: From a Translational Perspective

Sleep spindles and cognition in depression

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