Further evidence validating adjuvant arthritis as an experimental model of chronic pain in the rat

Colpaert, F. C.; Meert, Theo; Witte, Philippe De; Schmitt, Pierre

doi:10.1016/0024-3205(82)90402-7

Cited by 162 publications

(77 citation statements)

References 7 publications

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“…Increased paw diameter (posterior and anterior) due to inflammation and edema was also observed (Cain et al, 1997). The initial inflammatory response was developed within hours, but more critical clinical signals emerged from day 10 and thereafter, and the alterations remain detectable for several weeks (Clopaert et al, 1982). The results of the present study indicate that the EIA exhibits anti-arthritic effects in rats with Freund's adjuvant-induced arthritis, on its acute as well as its chronic phases.…”

Section: Resultssupporting

confidence: 63%

Effect ofIndigofera aspalathoideson complete Freund’s adjuvant-induced arthritis in rats

Balasubramanian¹,

Kavimani²,

Ravichandiran

et al. 2009

Pharmaceutical Biology

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Section: Resultssupporting

confidence: 63%

Effect ofIndigofera aspalathoideson complete Freund’s adjuvant-induced arthritis in rats

Balasubramanian¹,

Kavimani²,

Ravichandiran

et al. 2009

Pharmaceutical Biology

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“…The initial inflammatory response is developed within hours, but more critical clinical signs observed from the 10 th post-inoculation day and thereafter and the changes remain detectable for several weeks (Colpaert et al, 1982). The present study demonstrated that AML extract is able to suppress the swelling of the paws in both acute and chronic phases.…”

Section: Chan Pit Foong and Roslida Abdul Hamidsupporting

confidence: 54%

“…Rheumatoid arthritis (RA), defined as a symmetric polyarticular arthritis that basically affects small diarthroidal joints of the hands and feet, is the most common inflammatory arthritis as well as a major cause of disability (Firestein, 2003). The model of adjuvant induced arthritis in rats has been extensively used in the study of inflammatory processes (Jones & Ward, 1966) and validated as a model of chronic pain (Colpaert et al, 1982). Rats were selected to induce arthritis because they develop a chronic swelling in multiple joints due to accumulation of inflammatory cells, erosion of joint cartilage and bone destruction.…”

Section: Chan Pit Foong and Roslida Abdul Hamidmentioning

confidence: 99%

Evaluation of anti-inflammatory activities of ethanolic extract of Annona muricata leaves

Foong

Hamid

2012

Rev. bras. farmacogn.

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Traditionally, the leaves of Annona muricata L., Annonaceae, are used to treat headaches, fever, toothache, cough and asthma. The decoction of the leaves has parasiticide, antirheumatic and antineuralgic effects when used internally, while the cooked leaves, applied topically, fight rheumatism and abscesses. The aim of this study was to investigate acute and chronic anti-inflammatory potential of an ethanolic leaf extract of A. muricata (AML) in animal models. The ethanolic extract of A. muricata leaf extract was prepared and administered orally to experimental animals used. The anti-inflammatory activity was determined by xylene-induced ear edema in mice and Complete Freund's adjuvant (CFA)-induced arthritis in rats. The results demonstrated that AML is effective for both acute and chronic inflammation. It also significantly attenuated both TNF-α and IL-1β levels in CFAinduced arthritis model. Thus, these results have suggested that AML possesses both anti-inflammatory and anti-arthritic activities. The findings also suggest that AML presents notable anti-arthritic activity that may be mediated by suppressing proinflammatory cytokines.

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“…Aliquots of the methanolic supernatant (50 µl) were prediluted with buffer (500 µl) and incubated with nomodulatory and analgesic effects of drugs (6,18,(23)(24)(25).…”

Section: Discussionmentioning

confidence: 99%

“…This model has also proved to be a useful tool for investigating new analgesic and anti-inflammatory compounds (6,7).…”

Section: Introductionmentioning

confidence: 99%

Cyclosporin inhibits hyperalgesia and edema in arthritic rats: role of the central nervous system

Francischi¹,

Pereira²,

Castro³

1997

Braz J Med Biol Res

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Since arthritis induced by Mycobacterium products (adjuvant) in rats is considered to be immunologically driven, the objective of the present study was to determine if the immunosuppressor drug cyclosporin could affect hindpaw edema and joint hyperalgesia simultaneously. Female Holtzman rats (140-170 g) presented hyperalgesia and edema on the 8th and 12th day following adjuvant injection. Daily systemic (oral or intramuscular) administration of cyclosporin (0.5-5.0 mg kg -1 day -1 ) or dexamethasone (0.01-0.1 mg kg -1 day -1 ) for 15 days starting on day zero dose-dependently inhibited the hindpaw edema and hyperalgesia in arthritic rats. However, hyperalgesia but not edema could be detected two days after cyclosporin withdrawal. We concluded that a) the continuous presence of cyclosporin is essential to reduce the development of joint hyperalgesia and that b) different mechanisms underlie the appearance of hyperalgesia and edema in this model. The intracerebroventricular (icv) administration of 5-50-fold smaller doses of cyclosporin (1.5-150 µg/day) or dexamethasone (15 µg/day) also reduced the arthritic hindpaw edema and hyperalgesia. Peripheral blood from animals injected with effective systemic cyclosporin doses showed detectable levels of the drug, whereas peripheral blood from those injected with icv cyclosporin did not, as measured by specific RIA. Our results indicate that cyclosporin administered by the central route is as effective as by the systemic route to reduce joint hyperalgesia and hindpaw edema in arthritic rats. The antiarthritic effect induced by low doses of cyclosporin in the central nervous system (CNS) could be explored to avoid its often associated systemic side effects during chronic therapy. However, the mechanism(s) involved in the antiarthritic response to cyclosporin in the CNS remain to be elucidated. Correspondence

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Further evidence validating adjuvant arthritis as an experimental model of chronic pain in the rat

Cited by 162 publications

References 7 publications

Effect ofIndigofera aspalathoideson complete Freund’s adjuvant-induced arthritis in rats

Effect ofIndigofera aspalathoideson complete Freund’s adjuvant-induced arthritis in rats

Evaluation of anti-inflammatory activities of ethanolic extract of Annona muricata leaves

Cyclosporin inhibits hyperalgesia and edema in arthritic rats: role of the central nervous system

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