Further Evidence of the Melatonin Calmodulin Interaction: Effect on CaMKII Activity

Argueta, Jesús; Solís‐Chagoyán, Héctor; Estrada-Reyes, Rosa; Constantino‐Jonapa, Luis A.; Oikawa-Sala, Julián; Velázquez‐Moctezuma, Javier; Benítez‐King, Gloria

doi:10.3390/ijms23052479

Cited by 19 publications

(16 citation statements)

References 45 publications

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“…Ca 2+ /CaM activates CaMKII directly or activates CaMK-kinase (CaMKK), which in turn phosphorylates CaMKIV [57] [58] [59] [60] [61]. Recent evidence suggests that Ca 2+ -CaM-MEL increased the activity of CaMKII in some experimental conditions [62]. Compared to MEL, AMK has been reported to have a higher affinity for Ca2+-CaM [63].…”

Section: Discussionmentioning

confidence: 99%

Melatonin Enhances Object Recognition Memory through Melatonin MT1 and MT2 Receptor-Mediated and Non-Receptor-Mediated Mechanisms in Male Mice

Sano¹,

Iwashita²,

Hattori³

et al. 2022

JBBS

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Melatonin (MEL) has been reported to have acute enhancing effects on some aspects of cognition. Recently, we revealed that N1-acetyl-5-methoxyquinuramine (AMK), a brain metabolite of MEL, is much more potent than MEL in converting short-term memory (STM) to long-term memory (LTM) with a single administration immediately after the acquisition trial of the novel object recognition (NOR) task. These data suggest that the memory-enhancing effects of MEL may be mediated by mechanisms independent of the activation of MEL MT1 and MT2 receptors. In the present study, we examined the contribution of MT1 and MT2 receptor-mediated and non-receptor-mediated mechanisms to the acute memory-enhancing effects of MEL using NOR task. Mice were administered with either MEL, AMK, or a highly selective MT1/MT2 receptor agonist ramelteon (RAM) immediately after the acquisition trial and the effects of varying doses of these drugs on both STM and LTM performance were compared. We found that both AMK and RAM were more potent than MEL in both facilitating STM and promoting LTM formation. We also found that pretreatment with luzindole, a MT1/MT2 receptor antagonist, markedly suppressed only the effects of RAM. These results suggest that acutely administered MEL enhances NOR memory through both MT1 and MT2 receptormediated and non-receptor-mediated mechanisms.

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Section: Discussionmentioning

confidence: 99%

Melatonin Enhances Object Recognition Memory through Melatonin MT1 and MT2 Receptor-Mediated and Non-Receptor-Mediated Mechanisms in Male Mice

Sano¹,

Iwashita²,

Hattori³

et al. 2022

JBBS

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“…In fact, MT1 and MT2 receptors are expressed in the clone of ONPs used in this study, and previously it was demonstrated that olfactory neurons express NMDA receptors [ 21 , 49 ]. On the other hand, mitochondria play a key role in proliferation and at mitochondrial level; melatonin maintains the membrane potential, ROS balance, and ATP synthesis, the intramitochondrial synthesis of melatonin, as well as the indolamine release in the cytosol and diffusion into the intracellular membranes where it can produce intracrine effects, especially in the binding to calmodulin and the activation of its protein targets such as CaMK II [ 50 , 51 ].…”

Section: Discussionmentioning

confidence: 99%

Antidepressant Low Doses of Ketamine and Melatonin in Combination Produce Additive Neurogenesis in Human Olfactory Neuronal Precursors

et al. 2022

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Melatonin (MEL), an indolamine with diverse functions in the brain, has been shown to produce antidepressant-like effects, presumably through stimulating neurogenesis. We recently showed that the combination of MEL with ketamine (KET), an NMDA receptor antagonist, has robust antidepressant-like effects in mice, at doses that, by themselves, are non-effective and have no adverse effects. Here, we show that the KET/MEL combination increases neurogenesis in a clone derived from human olfactory neuronal precursors, a translational pre-clinical model for effects in the human CNS. Neurogenesis was assessed by the formation of cell clusters > 50 µm in diameter, positively stained for nestin, doublecortin, BrdU and Ki67, markers of progenitor cells, neurogenesis, and proliferation. FGF, EGF and BDNF growth factors increased the number of cell clusters in cultured, cloned ONPs. Similarly, KET or MEL increased the number of clusters in a dose-dependent manner. The KET/MEL combination further increased the formation of clusters, with a maximal effect obtained after a triple administration schedule. Our results show that the combination of KET/MEL, at subeffective doses that do not produce adverse effects, stimulate neurogenesis in human neuronal precursors. Moreover, the mechanism by which the combination elicits neurogenesis is meditated by melatonin receptors, CaM Kinase II and CaM antagonism. This could have clinical advantages for the fast treatment of depression.

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“…This preserved the integrity of the ovarian reserve and delayed ovarian aging; the actions of melatonin seem not to require the conventional transmembrane melatonin receptors but may have involved intracellular binding sites, e.g., quinone reductase-2, calmodulin or RZR/RORα nuclear binding, etc. [ 219 , 220 ].…”

Section: Delaying Infertility With Melatoninmentioning

confidence: 99%

Aging-Related Ovarian Failure and Infertility: Melatonin to the Rescue

et al. 2023

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Aging has a major detrimental effect on the optimal function of the ovary with changes in this organ preceding the age-related deterioration in other tissues, with the middle-aged shutdown leading to infertility. Reduced fertility and consequent inability to conceive by women in present-day societies who choose to have children later in life leads to increased frustration. Melatonin is known to have anti-aging properties related to its antioxidant and anti-inflammatory actions. Its higher follicular fluid levels relative to blood concentrations and its likely synthesis in the oocyte, granulosa, and luteal cells suggest that it is optimally positioned to interfere with age-associated deterioration of the ovary. Additionally, the end of the female reproductive span coincides with a significant reduction in endogenous melatonin levels. Thus, the aims are to review the literature indicating melatonin production in mitochondria of oocytes, granulosa cells, and luteal cells, identify the multiple processes underlying changes in the ovary, especially late in the cessation of the reproductive life span, summarize the physiological and molecular actions of melatonin in the maintenance of normal ovaries and in the aging ovaries, and integrate the acquired information into an explanation for considering melatonin in the treatment of age-related infertility. Use of supplemental melatonin may help preserve fertility later in life and alleviate frustration in women delaying childbearing age, reduce the necessity of in vitro fertilization–embryo transfer (IVF-ET) procedures, and help solve the progressively increasing problem of non-aging-related infertility in women throughout their reproductive life span. While additional research is needed to fully understand the effects of melatonin supplementation on potentially enhancing fertility, studies published to date suggest it may be a promising option for those struggling with infertility.

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Further Evidence of the Melatonin Calmodulin Interaction: Effect on CaMKII Activity

Cited by 19 publications

References 45 publications

Melatonin Enhances Object Recognition Memory through Melatonin MT1 and MT2 Receptor-Mediated and Non-Receptor-Mediated Mechanisms in Male Mice

Melatonin Enhances Object Recognition Memory through Melatonin MT1 and MT2 Receptor-Mediated and Non-Receptor-Mediated Mechanisms in Male Mice

Antidepressant Low Doses of Ketamine and Melatonin in Combination Produce Additive Neurogenesis in Human Olfactory Neuronal Precursors

Aging-Related Ovarian Failure and Infertility: Melatonin to the Rescue

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