Further Evidence of Prolactin Production from Human Decidua and Its Transport across Fetal Membrane

Abstract

In this study the human decidua, chorion and amnion were incubated for short term. Only the decidua, secreted much prolactin clearly among them as a function of time. When the amounts of prolactin in the maternal blood, cord blood obtained from umbilical vein, or those released into decidual incubation medium were compared with the amniotic fluid prolactin levels, only the decidual prolactin correlated significantly with the amniotic fluid prolactin. The urine obtained from newborns showed a low concentration of prolactin. These results suggest that the origin of prolactin present in the amniotic fluid is not from the mother or fetus, but from the decidua which has the ability of producing prolactin, and that prolactin secreted from this tissue may be transported into the amniotic fluid through the fetal membrane and accumulated there.

Decidual prolactin content and secretion at term: Correlations with the clinical data

“…The data of the uncomplicated and pathological pregnancies showed A-PRL significantly correlated with D-PRL, which is consistent with previous studies (3,4) and supports the hypothesis of a decidual origin for A-PRL. Improvement of this correlation when the week of gestation is included has not been reported earlier.…”

“…We found D-PRLs to be significantly correlated with D-PRL. However, the correlation coefficient was less convincing when compared with previous reports (3,4). We evaluated the D-PRLs following two preincubations and, thus, ensuring a fairly constant secretion rate (17).…”

Les membranes fœtales : développement embryologique, structure et physiopathologie de la rupture prématurée avant terme

“…Les cellules de l'endomètre se modifient (décidualisation) dès l'implantation du blastocyte et se chargent de glycogène et de lipides. L'interface entre le chorion et la décidua permet la diffusion de nutriments du versant maternel vers le versant foetal et sert également de barrière immunologique entre les deux compartiments [15][16][17][18][19][20][21].…”

Risk factors for food allergy

“…An alternate theory proposes allergen exposure across the fetal membranes, where the maternal (deciduas) and fetal tissues are in intimate contact [15]. The passage of proteins from the maternal to the fetal side of this membrane is already known to occur [16].…”