Further evidence for psoriasis susceptibility loci on chromosomes 6p21 and 17q and evidence for novel candidate regions at 1q21–q23, 4q13–q21 and 14q31

Filaggrin R501X and 2282del4 Mutations Are Not Associated with Chronic Plaque-Type Psoriasis in a German Cohort

“…Nevertheless, as new FLG variants are being determined, it remains possible that a different variant not yet discovered might play a role in psoriasis. In addition, the epidermal differentiation complex might still harbor a major gene for psoriasis as the PSORS4 locus has been repeatedly confirmed in independent patient cohorts (Bowcock et al, 1998;Capon et al, 2001;Giardina et al, 2006).…”

“…FLG is involved in the formation of the stratum corneum and homozygote or compound heterozygote R501X or 2282del4 mutations are leading to disturbed skin barrier function. Therefore FLG also appears to be an attractive candidate gene for the PSORS4 locus on chromosome 1q21 (Bowcock et al, 1998;Capon et al, 1999).…”