Further evidence for infection of pigs with human-like H1N1 influenza viruses in China

Yu, Hai; Zhou, Yanjun; Li, Guoxin; Zhang, Guihong; Liu, Huili; Yan, Liping; Liao, Ming; Tong, Guangzhi

doi:10.1016/j.virusres.2008.11.008

Cited by 34 publications

(17 citation statements)

References 31 publications

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“…The HA gene of the pandemic H1N1 belongs to the classical swine lineage whose ancestry has been traced to viruses similar to the human pandemic of 1918–19 (Garten et al, 2009). This lineage is known as classical swine influenza to distinguish it from other viruses of human or avian origin that were introduced into pigs more recently, giving rise to ‘human-like’ and ‘avian-like’ swine influenza lineages (Brown, 2000; Brown et al, 1997; Guan et al, 1996; Karasin et al, 2006, 2002, 2004; Pensaert et al, 1981; Vincent et al, 2006, 2009, 2008; Webby et al, 2004; Yu et al, 2009). The classical swine H1N1 virus has continued to circulate in pigs without interruption since 1930 (Brown, 2000; Vincent et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Receptor specificity of subtype H1 influenza A viruses isolated from swine and humans in the United States

et al. 2011

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The evolution of classical swine influenza viruses receptor specificity preceding the emergence of the 2009 H1N1 pandemic virus was analyzed in glycan microarrays. Classical swine influenza viruses from the α, β, and γ antigenic clusters isolated between 1945 and 2009 revealed a binding profile very similar to that of 2009 pandemic H1N1 viruses, with selectivity for α2-6-linked sialosides and very limited binding to α2-3 sialosides. Despite considerable genetic divergence, the ‘human-like’ H1N1 viruses circulating in swine retained strong binding preference for α2-6 sialylated glycans. Interspecies transmission of H1N1 influenza viruses from swine to humans or from humans to swine has not driven selection of viruses with distinct novel receptor binding specificities. Classical swine and human seasonal H1N1 influenza viruses have conserved specificity for similar α2-6-sialoside receptors in spite of long term circulation in separate hosts, suggesting that humans and swine impose analogous selection pressures on the evolution of receptor binding function.

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Section: Introductionmentioning

confidence: 99%

Receptor specificity of subtype H1 influenza A viruses isolated from swine and humans in the United States

et al. 2011

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“…In China, pigs have a short lifespan (approximately 6 months) and are not vaccinated with any type of swine influenza vaccine. Therefore, the viruses circulating in swine population might appear to have been under less immune selection pressure and all genes evolved more slowly than in humans and poultry [45]. The classical H1N1 remained highly conserved genetically until the 1990s, with only a limited number of nucleotide changes [46,47].…”

Section: Discussionmentioning

confidence: 99%

Isolation and complete genomic characterization of H1N1 subtype swine influenza viruses in southern China through the 2009 pandemic

Liu

Xie

et al. 2011

Virol J

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BackgroundThe swine influenza (SI) is an infectious disease of swine and human. The novel swine-origin influenza A (H1N1) that emerged from April 2009 in Mexico spread rapidly and caused a human pandemic globally. To determine whether the tremendous virus had existed in or transmitted to pigs in southern China, eight H1N1 influenza strains were identified from pigs of Guangdong province during 2008-2009.ResultsBased on the homology and phylogenetic analyses of the nucleotide sequences of each gene segments, the isolates were confirmed to belong to the classical SI group, with HA, NP and NS most similar to 2009 human-like H1N1 influenza virus lineages. All of the eight strains were low pathogenic influenza viruses, had the same host range, and not sensitive to class of antiviral drugs.ConclusionsThis study provides the evidence that there is no 2009 H1N1-like virus emerged in southern China, but the importance of swine influenza virus surveillance in China should be given a high priority.

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“…Although, it is virtually impossible to prevent new outbreaks of infl uenza in human and animals, it is now well-recognized that animal infl uenza virus surveillance can play a key role in the early recognition of outbreak threats. Therefore it is of great signifi cance to carry out swine infl uenza virus surveillance [66].…”

Section: Swine Infl Uenza and Zoonosesmentioning

confidence: 99%

Epidemiological update on swine influenza (H1N1) in pigs

2009

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The 2009 H1N1 pandemic has slowed down its spread after initial speed of transmission. The conventional swine infl uenza H1N1 virus (SIV) in pig populations worldwide needs to be differentiated from pandemic H1N1 infl uenza virus, however it is also essential to know about the exact role of pigs in the spread and mutations taking place in pig-to-pig transmission. The present paper reviews epidemiological features of classical SIV and its differentiation with pandemic infl uenza. -Derek Gatherer, 2009 (1) Keywords Swine fl u · Infl uenza · H1N1

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Further evidence for infection of pigs with human-like H1N1 influenza viruses in China

Cited by 34 publications

References 31 publications

Receptor specificity of subtype H1 influenza A viruses isolated from swine and humans in the United States

Receptor specificity of subtype H1 influenza A viruses isolated from swine and humans in the United States

Isolation and complete genomic characterization of H1N1 subtype swine influenza viruses in southern China through the 2009 pandemic

Epidemiological update on swine influenza (H1N1) in pigs

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