Further Evidence for Co-Segregation between Pediatric Obsessive Compulsive Disorder and Attention Deficit Hyperactivity Disorder: A Familial Risk Analysis

Geller, Daniel; Petty, Carter R.; Vivas, Fe; Johnson, Jessica; Pauls, David L.; Biederman, Joseph

doi:10.1016/j.biopsych.2006.09.026

Cited by 46 publications

(33 citation statements)

References 51 publications

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“…Interestingly, Geller et al (2007) provided evidence for cosegregation between paediatric OCD and ADHD by a familial risk analysis, indicating the possibility of common underlying genetic risk factors. Our results cannot be extrapolated directly to ADHD and OCD in the general population since 22q11.2DS subjects represent a particular and unique case.…”

Section: Discussionmentioning

confidence: 99%

Association between a common haplotype in the COMT gene region and psychiatric disorders in individuals with 22q11.2DS

Michaelovsky

Gothelf

Korostishevsky

et al. 2007

Int. J. Neuropsychopharm.

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The 22q11.2 deletion syndrome (22q11.2DS) is the most common hemizygous deletion syndrome in humans. In addition to a wide range of physical abnormalities 22q11.2DS subjects show high prevalence of several psychiatric disorders. In our previous study we showed that the low-activity allele (158Met) of the COMT gene is a risk factor for attention deficit hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD) in 22q11.2DS individuals. In the present study we have genotyped fifty-five 22q11.2DS individuals and 95 of their parents for eight SNPs in and around the COMT gene. A haplotype composed of three SNPs [rs2097603; rs4680 (158Val/Met); rs165599] representing the major linkage disequilibrium blocks in COMT and previously implicated in functional variation, was found to be associated with ADHD and OCD in 22q11.2DS individuals. A common risk haplotype (G-A-A) was significantly associated with both ADHD (OR 3.13, chi2=4.38, p=0.036) and OCD (OR 4.00, chi2=6.41, p=0.011) in 22q11.2DS individuals. Interestingly, the same haplotype was recently found to be associated with efficient prefrontal performance in the general population. The risk haplotype was not found to be associated with IQ scores in our 22q11.2DS sample. Parental origin of the deletion did not affect the susceptibility to ADHD and OCD in the 22q11.2DS subjects. This study demonstrated the association of a particular COMT haplotype with susceptibility to both ADHD and OCD in 22q11.2DS and supports the hypothesis that COMT gene variations contribute to genetic predisposition to psychiatric disorders in the general population.

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Section: Discussionmentioning

confidence: 99%

Association between a common haplotype in the COMT gene region and psychiatric disorders in individuals with 22q11.2DS

Michaelovsky

Gothelf

Korostishevsky

et al. 2007

Int. J. Neuropsychopharm.

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“…A genetic family risk analysis was suggestive of cosegregation between both disorders (Geller et al 2007b). Relatives of patients with ADHD who were affected by ADHD, as well, had a significantly elevated risk for OCD compared to relatives unaffected by ADHD (7.4 vs. 1.3%, P \ 0.001).…”

Section: Obsessive Compulsive Disorder (Ocd)mentioning

confidence: 97%

“…The authors' results supported the hypothesis that ADHD and OCD are independent conditions and that ''OCD ? ADHD'' might reflect a unique familial subtype (Geller et al 2007b).…”

Section: Obsessive Compulsive Disorder (Ocd)mentioning

confidence: 99%

Developmental comorbidity in attention-deficit/hyperactivity disorder

Taurines

Schmitt

Renner

et al. 2010

ADHD Atten Def Hyp Disord

162

116

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With the present review, we intend to highlight the importance of considering the age- and development-dependent occurrence of comorbidity in ADHD and to outline distinct trajectories of symptom progression with possible impact on course and outcome of ADHD. The review will focus on introducing the concepts of "developmental epidemiology" and "developmental comorbidity". Psychiatric and non-psychiatric age-dependent comorbidity can be seen in the majority of children, adolescents and adults with ADHD, resulting in a severe impairment of everyday life with considerable functional and psychosocial problems. Concerning the temporal order of occurrence, psychiatric conditions may be present before the appearance of first definite ADHD symptoms ("pre-comorbidity", such as temperament factors, sleep disturbance, autism spectrum disorders and atopic eczema). They may coincide with the time when ADHD symptoms reach a clinically significant level ("simultaneous comorbidity": enuresis, encopresis, developmental dyslexia). The majority of comorbidity, however, appears after the onset of ADHD in the course of disease ("post-comorbidity": tic disorder, depression and suicidality, anxiety disorders, obsessive compulsive disorder, bipolar disorder, conduct and substance use disorders, obesity and personality disorders). The aetio-pathophysiology of ADHD and its comorbid disorders and also the nature of comorbidity itself being highly heterogeneous, we additionally discuss possible models of comorbidity. In the future, longitudinal data on distinct patterns of symptom and comorbidity progression would help to refine disease classification systems, strengthen the power of future genetic studies and finally allow for more specific treatment strategies.

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“…However, research into OCD-ADHD prevalence rates reveals highly inconsistent results. In studies reporting the incidence of ADHD in samples of OCD patients, comorbidity rates vary from a range of 0-25% in some studies (Farrell & Barrett, 2006;Heyman et al, 2001;Ivarsson, Melin, & Wallin, 2008;Storch et al, 2007) to a range of 33-59% in others (Geller et al, 2001(Geller et al, , 2002(Geller et al, , 2000(Geller et al, , 2006(Geller et al, , 2007Geller, Biederman, Griffin, Jones, & Lefkowitz, 1996). Rates were much lower in the few studies that reported the co-occurrence of OCD in samples of juveniles diagnosed with ADHD, ranging between 0% and 6% Moll et al, 2000;Skirbekk, Hansen, Oerbeck, & Kristensen, 2011;Zohar, 1999).…”

Section: Introductionmentioning

confidence: 96%

Don’t judge a book by its cover: ADHD-like symptoms in obsessive compulsive disorder

Abramovitch¹,

Dar²,

Mittelman³

et al. 2013

Journal of Obsessive-Compulsive and Related Disorders

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Further Evidence for Co-Segregation between Pediatric Obsessive Compulsive Disorder and Attention Deficit Hyperactivity Disorder: A Familial Risk Analysis

Cited by 46 publications

References 51 publications

Association between a common haplotype in the COMT gene region and psychiatric disorders in individuals with 22q11.2DS

Association between a common haplotype in the COMT gene region and psychiatric disorders in individuals with 22q11.2DS

Developmental comorbidity in attention-deficit/hyperactivity disorder

Don’t judge a book by its cover: ADHD-like symptoms in obsessive compulsive disorder

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