Further evidence for an association between psoriasis, Crohn's disease and ulcerative colitis

Abstract

To test the hypothesis that psoriasis is associated with Crohn's disease and ulcerative colitis, 204 patients with inflammatory bowel disease (116 with Crohn's disease and 88 with ulcerative colitis) and 204 age and sex matched controls were interviewed and examined. The prevalance of psoriasis in Crohn's disease (II.2%) and in ulcerative colitis (5.7%), was significantly greater than in the control group (1.5%). The prevalence of psoriasis in first degree relatives of patients with inflammatory bowel disease was also increased. It is suggested that there is a relationship between psoriasis, ankylosing spondylitis, sacroiliitis, peripheral arthropathy and inflammatory bowel disease, which may be explained by common genetic factors.

Differential contribution of CDKAL1 variants to psoriasis, Crohn's disease and type II diabetes

“…This suggests a pathogenetic mechanism, whereby risk alleles at shared disease loci may account for the increased incidence of psoriasis among CD patients. 32,33 Our results also show that the CDKAL1 SNP conferring susceptibility to TIID is not associated with psoriasis or CD, thus validating the presence of two independent association signals at this locus. It is to be noted that the psoriasis associated SNP (rs6908425), the TIID associated SNP (rs10946398) and the various markers that are in LD with them (rs4712528, rs7748720 for rs6908425; rs9460546, rs9565871 for rs10946398; r 2 40.8 for all) all map to CDKAL1 intron 5, suggesting that this gene region may contain important regulatory elements.…”

National Psoriasis Foundation clinical consensus on psoriasis comorbidities and recommendations for screening

“…[128][129][130] In a series of case-control studies, 7-11% of those with Crohn's disease were diagnosed with psoriasis compared to 1-2% of controls. [131][132][133] Relatives of subjects diagnosed with either Crohn's or psoriasis also have been shown to have an increased incidence of having the other disease. 134 Genetic [135][136][137][138] and pathologic [139][140][141][142] connections between these two diseases support these findings, and most recently both have been linked to specific gentotypes of IL-23.…”

Extraintestinal Manifestations of Ulcerative Colitis

“…In one study, of 88 patients with UC, 5.7% had psoriasis, compared to 1.5% in the control group, suggesting some type of genetic relationship between the two (Yates et al, 1982). Another study found an association between UC and hidradenitis suppurativa [FIGURE 6].…”