Abstract:From the analysis of the HRNMR spectra of two tricyclic analogues of adenosine and guanosine, 4,5-diamino-9-(β-D-ribofuranosyl) pyrimido[5,4-f]pyrrolo[2,3-d]pyrimidine (adenosine-adenosine, AA) and 4,7-diamino-9-(β-ᴅ-ribofuranosyl)pyrimido[5,4-f]pyrrolo-[2,3-d]pyrimidin-5-one (adenosine-guanosine, AG), dissolved in liquid ND3 the preferred conformations of the ribose moiety are derived in the temperature range between + 40 and -60 °C. The analysis is based on the two state N ↔ S model of the furanoside ring p… Show more
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