Further Epidemiological Studies of Subacute Sclerosing Panencephalitis

Detels, Roger; McNew, Jane; Brody, JacobA.; Edgar, AnneH

doi:10.1016/s0140-6736(73)91946-6

Cited by 88 publications

(21 citation statements)

References 10 publications

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“…139 One early case-control study suggested that children with SSPE were more likely to have had varicella within 6 months of measles than were controls. 140 A subsequent larger study found no differences between cases and controls in histories of chickenpox, mumps, or rubella occurring within 6 months of measles. 139 Measles vaccine prevents SSPE by preventing measles; SSPE has almost completely disappeared from the United States and other developed countries in recent years.…”

Section: Subacute Sclerosing Panencephalitis (Sspe)mentioning

confidence: 90%

Measles-Mumps-Rubella Vaccine and Autistic Spectrum Disorder: Report From the New Challenges in Childhood Immunizations Conference Convened in Oak Brook, Illinois, June 12–13, 2000

Halsey¹,

Hyman²

2001

Pediatrics

138

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ABSTRACT. Background. Parents and physicians are understandably concerned about the causes and treatment of autism, a devastating disease that affects the entire family. Although much has been learned about autism, there are many gaps in our knowledge about what causes the disorder and how it can be prevented. Autistic symptoms occur along a spectrum, often referred to as autistic spectrum disorder (ASD). Concern has been raised about a possible association between measlesmumps-rubella (MMR) vaccine and inflammatory bowel disease (IBD) and ASD, especially autism with regression. Also, increased requests for educational services related to ASD have raised concerns about possible increases in the incidence of ASD.Methods. On June 12-13, 2000, the American Academy of Pediatrics (AAP) convened a conference titled "New Challenges in Childhood Immunizations" in Oak Brook, Illinois. At this conference, parents, practitioners, and scientists presented information and research on MMR vaccine and ASD. Attendees included representatives from select AAP committees and sections as well as federal and other organizations that address related issues. The multidisciplinary panel of experts reviewed data on what is known about the pathogenesis, epidemiology, and genetics of ASD and the available data on hypothesized associations with IBD, measles, and MMR vaccine. Supplemental information was requested from authors who have proposed the hypotheses and other experts in relevant areas.Results. Autism is a complex disorder of uncertain and probably multiple etiologies. Genetic predisposition to ASD may involve as many as 10 genes. Many experts believe that the abnormal brain development in autism occurs before 30 weeks' gestation in most instances. In utero rubella is a known cause of autism. Animal model data support the biologic plausibility that exposure to yet unrecognized infectious or other environmental agents could cause ASD.Several factors may contribute to apparent increases in incidence of ASD in recent years. Most data indicate increased recognition and reporting as primary factors, but the epidemiologic data are insufficient to determine if there has been a true increase in the incidence of ASD. Increased reporting of ASD in recent years has occurred long after the introduction of MMR vaccine in the United States in 1971 and widespread use of this vaccine in the 1970s for routine immunization of children at 12 to 15 months of age. Appropriate detailed studies are needed to define the true incidence and prevalence of ASD. Epidemiologic studies in Europe indicate no association between MMR vaccine and ASD.Some children with ASD have gastrointestinal symptoms, but an increased rate of any specific gastrointestinal disorder in children with ASD has not been established. Studies to detect evidence of measles virus in intestinal tissue specimens from patients with IBD or autism with gastrointestinal symptoms have not used uniform techniques. Several laboratories have found no evidence of measles viruses in tissue specimens f...

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Section: Subacute Sclerosing Panencephalitis (Sspe)mentioning

confidence: 90%

Measles-Mumps-Rubella Vaccine and Autistic Spectrum Disorder: Report From the New Challenges in Childhood Immunizations Conference Convened in Oak Brook, Illinois, June 12–13, 2000

Halsey¹,

Hyman²

2001

Pediatrics

138

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“…La prévalence de cette forme est estimée entre 1/100 000 à 1/8 500 000 [16,[26][27][28]. Les symptômes surviennent en moyenne sept ans après la primo-infection et associent des troubles de la personnalité, des convulsions cloniques et des troubles moteurs.…”

Section: Manifestations Cliniques De La Rougeoleunclassified

Rougeole chez la femme enceinte : mise au point

Guillet

Vauloup‐Fellous

Cordier

et al. 2012

Journal de Gynécologie Obstétrique et Biologie de la Reproducti

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“…In addition, despite the fact that combination therapy is more costly than interferon monotherapy, Wong et al (2) now report in this issue that combination therapy is more costeffective than interferon monotherapy. This study, as well as one published recently by Younossi et al (3) used published data about virological response rates from the large registration trials reported in late 1998. Despite differences in the models employed, both studies indicate that the most costeffective strategy for previously untreated patients is the use of combination therapy.…”

Section: Outcomes and Costs Of Care In Hepatitis C: Combination Theramentioning

confidence: 99%

Measles virus as a risk for inflammatory bowel disease: an unusually tolerant approach

Wakefield¹

2000

The American Journal of Gastroenterology

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Further Epidemiological Studies of Subacute Sclerosing Panencephalitis

Cited by 88 publications

References 10 publications

Measles-Mumps-Rubella Vaccine and Autistic Spectrum Disorder: Report From the New Challenges in Childhood Immunizations Conference Convened in Oak Brook, Illinois, June 12–13, 2000

Measles-Mumps-Rubella Vaccine and Autistic Spectrum Disorder: Report From the New Challenges in Childhood Immunizations Conference Convened in Oak Brook, Illinois, June 12–13, 2000

Rougeole chez la femme enceinte : mise au point

Measles virus as a risk for inflammatory bowel disease: an unusually tolerant approach

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