Further eleganolone-derived diterpenes from the brown alga Bifurcaria bifurcata

Göthel, Qun; Lichte, Ellen; Köck, Matthias

doi:10.1016/j.tetlet.2011.09.128

Cited by 16 publications

(21 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two studies on Bifucaria bifurcata (Roscoff, France) dened the metabolic makeup of this alga with the isolation of the sesquiterpenoids formyleleganolone 463, bibifuran 464 and four new eleganolone derivatives 465-468. 481,482 Also isolated were eleganolone, 483 ve previously described eleganolone derivatives [484][485][486][487][488] and 16-hydroxygeranylgeraniol 489 (isolated for the rst time from this species) which collectively can be correlated in a hypothetical metabolic grid. 482 In a follow-up study the structures and relative congurations of a further 13 dolabellane diterpenoids 469-481 from the alga Dilophus spiralis (Elafonissos Is., Greece) were described along with the antibacterial properties of 469-477 and 481.…”

Section: Brown Algaementioning

confidence: 99%

Marine natural products

et al. 2014

View full text Add to dashboard Cite

This review covers the literature published in 2012 for marine natural products, with 1035 citations (673 for the period January to December 2012) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1241 for 2012), together with the relevant biological activities, source organisms and country of origin. Biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

show abstract

Section: Brown Algaementioning

confidence: 99%

Marine natural products

et al. 2014

View full text Add to dashboard Cite

show abstract

“…This brown macroalga lives in rock pools on the lower and middle tidal, needing shores for its settlement, and is distributed along the coast of the Northern Atlantic, between Morocco and Northwestern Ireland [17]. About 56% of the published (and here reviewed) studies concerning the linear diterpenes fraction of B. bifurcata use samples from the coast of France (Figure 1), which may be associated with the high abundance of this macroalga on that area [8,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37].…”

Section: Bifurcaria Bifurcata General Characteristics and Linear Dmentioning

confidence: 99%

“…In fact, eleganediol ( 9 ) [19,23,24,26,28,29,31,33,36,37], bifurcane ( 10) [29,30,31,36], and eleganolone ( 15 ) [20,21,22,23,24,26,27,28,30,31,36,37] have been described in several studies concerning B. bifurcata from France, together with other linear diterpenes, namely formyleleganolone ( 35 ) and bibifuran ( 36 ) [34]. The highest eleganediol ( 9 ) and bifurcane ( 10 ) contents (1.12% and 0.37% of dw, respectively) were described by Maréchal et al [36].…”

Section: Bifurcaria Bifurcata General Characteristics and Linear Dmentioning

confidence: 99%

Current Research on the Bioprospection of Linear Diterpenes from Bifurcaria bifurcata: From Extraction Methodologies to Possible Applications

et al. 2019

View full text Add to dashboard Cite

Marine resources are considered as a very promising source of bioactive molecules, and macroalgae in particular have gained special attention, due to their structurally diverse composition. Particular interest has been devoted to the brown macroalga Bifurcaria bifurcata, due to their abundance in bioactive linear diterpenes. In this appraisal, a thorough review concerning the methodologies used in the extraction, fractionation, and identification of diterpenes from B. bifurcata is provided and discussed in detail. An exhaustive compilation of the mass spectra and nuclear magnetic resonance (NMR) data are also provided. The in vitro and in chemico assays already performed to assess different biological activities attributed to B. bifurcata diterpenes are also reviewed, emphasizing the use of isolated components, enriched fractions, or crude extracts. The associated major strengths and challenges for the exploitation of B. bifurcata diterpenes for high-value applications are critically discussed.

show abstract

“…The phytochemistry of B. bifurcata has been extensively investigated and compounds such as sterols, polyphenols, diterpenes have been reported. Eleganolone was described as the major oxygenated diterpene [ 28 , 62 , 63 , 64 , 65 , 66 ]. The compounds present in the alga may be responsible for the antileishmanial activities.…”

Section: Current Status Of Antileishmanial Drug Discovery From Marmentioning

confidence: 99%

Marine Algae as Source of Novel Antileishmanial Drugs: A Review

et al. 2017

View full text Add to dashboard Cite

Leishmaniasis is a vector-borne neglected tropical disease caused by protozoan parasites of the Leishmania genus and transmitted by the female Phlebotomus and Lutzomyia sand flies. The currently prescribed therapies still rely on pentavalent antimonials, pentamidine, paromomycin, liposomal amphotericin B, and miltefosine. However, their low efficacy, long-course treatment regimen, high toxicity, adverse side effects, induction of parasite resistance and high cost require the need for better drugs given that antileishmanial vaccines may not be available in the near future. Although most drugs are still derived from terrestrial sources, the interest in marine organisms as a potential source of promising novel bioactive natural agents has increased in recent years. About 28,000 compounds of marine origin have been isolated with hundreds of new chemical entities. Recent trends in drug research from natural resources indicated the high interest of aquatic eukaryotic photosynthetic organisms, marine algae in the search for new chemical entities given their broad spectrum and high bioactivities including antileishmanial potential. This current review describes prepared extracts and compounds from marine macroalgae along with their antileishmanial activity and provides prospective insights for antileishmanial drug discovery.

show abstract

Further eleganolone-derived diterpenes from the brown alga Bifurcaria bifurcata

Cited by 16 publications

References 15 publications

Marine natural products

Marine natural products

Current Research on the Bioprospection of Linear Diterpenes from Bifurcaria bifurcata: From Extraction Methodologies to Possible Applications

Marine Algae as Source of Novel Antileishmanial Drugs: A Review

Contact Info

Product

Resources

About