Further discussion of the themes

Abstract

Anaplasticlargecelllymphomawith haemophagocyticsyndrome ALK-negativeanaplasticlargecelllymphoma: 1) GenerallyoccursatanolderagethanALK-positivecases 2) HasabetterprognosisthanALK-positiveanaplasticlargecelllymphoma 3) Hassimilarhistologicalandimmunophenotypicfeaturestobreastimplant-associatedanaplasticlargecelllymphoma 4) Isusuallyassociatedwitht(2;5)(p23.2-23.1;q35.1) 5) Usuallypresentswithlocaliseddisease Correct answers 1, 3ALK-negativeanaplasticlargecelllymphomatypicallyoccursatanolderagethanALK-positive casesandhasaworseprognosis.PresentationisusuallywithstageIIIorIVdisease.Althoughthey arehistologicallyindistinguishable,thesearequitedifferentconditions.ItisALK-positivecases thatareassociatedwitht(2;5),leadingtoformationofanNPM1-ALKfusiongene.Breastimplantassociatedcasesarealsohistologicallyindistinguishablebutareaquitedistinctdiseasethat usually remainslocalisedandhasamuchbetterprognosis. BonemarrowALamyloidosisAmyloidintissuesectionscanbeidentifiedbypositivestainingwith:1) Congored 2) Martiusscarletblue 3) Methenaminesilver 4) Prussianblue 5) Siriusred Correct answers 1, 5CongoredandSiriusredbothstainamyloidand,onexaminationbypolarisedlight,thereisapplegreen birefringence. Martius scarlet blue stains collagen, methenamine silver stains fungi and Prussianbluestainshaemosiderin.