Further data on the structure of brown seaweed fucans: relationships with anticoagulant activity

Chevolot, Lionel; Foucault, Alain; Chaubet, Frédéric; Kervarec, Nelly; Sinquin, Corinne; Fisher, Anne-Marie; Boisson-Vidal, Catherine

doi:10.1016/s0008-6215(99)00127-5

Cited by 296 publications

(178 citation statements)

References 30 publications

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“…They are also successfully used for prevention and treatment of such widespread diseases as high blood pressure, arthritis, diabetes and obesity. These bioactive properties largely depend on molecular weight sulfate content and position, as well as molecular structure of the polysaccharides [26].…”

Section: Figmentioning

confidence: 99%

Studies on Fucoidan and Its Production From Vietnamese Brown Seaweeds

Lý¹,

Buu²,

Nhut³

et al. 2017

AJSTD

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Sulfated fucans are among the most widely studied of all the sulfated polysaccharides of plant origin that exhibit biological activities in mammalian systems. In this report fucoidans from some Vietnamese Sargassum species such as S. polycystum, S. oligocystum, S. mcclurei, S. swartzii and denticaprum were extracted and fractionated on a DEAE-Sephadex A-25 column.On the basis of chemical and spectral analyses, the fucoidan fractions obtained were found to be the sulfated fucogalactans containing sulfate ester groups and uronic acid, and composed essentially of fucose and galactose, as well as a minor amount of other sugars. The polysaccharide fractions were tested for anticancer activity. The primarily obtained results showed that all fucoidan fractions isolated from S. swartzii demonstrate bioactivity effects against cancer cells, while fraction F5 with a highest sulfate content exhibits the strongest antiinvasion activity. This indicates that sulfate content plays an important role in the anticancer activity of the brown algal fucoidans.A laboratory scale pilot for fucoidan production from Vietnamese brown seaweeds has been set with a capacity of 500 g of crude fucoidan per day.

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Section: Figmentioning

confidence: 99%

Studies on Fucoidan and Its Production From Vietnamese Brown Seaweeds

Lý¹,

Buu²,

Nhut³

et al. 2017

AJSTD

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“…The list of bioactivity of fucoidan for human health is long. Fucoidan found in seaweed such as Undaria and Laminaria shows anticoagulant, anti-viral and anti-cancer properties; Chevolot et al 1999;Zhuang et al 1995).…”

Section: Fucoidan/fucans/fucanoidsmentioning

confidence: 99%

Algal Polysaccharides, Novel Applications and Outlook

Kraan¹

2012

Carbohydrates - Comprehensive Studies on Glycobiology and Glycotechnology

180

173

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“…In fact, for these plant polysaccharides even high-field NMR is of limited value, and complete descriptions of their structures are not available at present (2). However, meaningful structural studies using NMR are possible with relative low molecular weight (LMW) fucans that have been prepared by several methods such as acid hydrolysis of high molecular weight (HMW) fucans (8,9) or extration from brown seaweeds (10).…”

Section: Structural Features Of Fucansmentioning

confidence: 99%

“…Studies with LMW fucans obtained by chemical hydrolysis of HMW fucans have demonstrated that 3-and/or 4-linked fucose residues are always present, sulfation at the 2 and 4 positions can also be identified in these polymers and their biological activities are apparently related not only to molecular weight and sulfation, but also the quantity and position of the sulfated residues in the compound (1,6,8). Recently, Nagaoka et al (4), using data from partial acid hydrolysis, methylation and NMR analysis, proposed the average structure of a 56-kDa fucan.…”

Section: Structural Features Of Fucansmentioning

confidence: 99%

A fucan from the brown seaweed Spatoglossum schröederi inhibits Chinese hamster ovary cell adhesion to several extracellular matrix proteins

Rocha

Franco

Trindade

et al. 2001

Braz J Med Biol Res

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Fucans, a family of sulfated polysaccharides present in brown seaweed, have several biological activities. Their use as drugs would offer the advantage of no potential risk of contamination with viruses or particles such as prions. A fucan prepared from Spatoglossum schröederi was tested as a possible inhibitor of cell-matrix interactions using wild-type Chinese hamster ovary cells (CHO-K1) and the mutant type deficient in xylosyltransferase (CHO-745). The effect of this polymer on adhesion properties with specific extracellular matrix components was studied using several matrix proteins as substrates for cell attachment. Treatment with the polymer inhibited the adhesion of fibronectin to both CHO-K1 (2 x 10 5 ) and CHO-745 (2 x 10 5 and 5 x 10 5 ) cells. No effect was detected with laminin, using the two cell types. On the other hand, adhesion to vitronectin was inhibited in CHO-K1 cells and adhesion to type I collagen was inhibited in CHO-745 cells. In spite of this inhibition, the fucan did not affect either cell proliferation or cell cycle. These results demonstrate that this polymer is a new anti-adhesive compound with potential pharmacological applications.

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Further data on the structure of brown seaweed fucans: relationships with anticoagulant activity

Cited by 296 publications

References 30 publications

Studies on Fucoidan and Its Production From Vietnamese Brown Seaweeds

Studies on Fucoidan and Its Production From Vietnamese Brown Seaweeds

Algal Polysaccharides, Novel Applications and Outlook

A fucan from the brown seaweed Spatoglossum schröederi inhibits Chinese hamster ovary cell adhesion to several extracellular matrix proteins

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