Further clinical trials on macrolides for bronchiolitis in infants are unnecessary

McCallum, Gabrielle B.; Chang, Anne B.; Grimwood, Keith

doi:10.1016/j.jaci.2015.07.012

Cited by 4 publications

(3 citation statements)

References 7 publications

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“…No positive contribution to healing at clinical follow-up or significantly significant difference in length of hospital stay was observed between the group using iv or oral antibiotics and the no antibiotic group. McCallum et al 20 compared patients receiving a single dose of azithromycin with a placebo group, and determined no significant variation in patients' clinical improvement or length of stay at hospital. Our findings were compatible with those of these previous studies.…”

Section: Discussionmentioning

confidence: 99%

Does Clarithromycin Use in Acute Viral Bronchiolitis Shorten Length of Hospital Stay?

Esenülkü¹,

Hancı²

2020

J. Pediatr. Acad.

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Introduction: Acute bronchiolitis is the most common cause of hospitalization among infants. Although antibiotics are not recommended in the absence of secondary bacterial infection, rates of antibiotic usage is high rate in clinical practices Objectives: To test the hypothesis that clarithromycin use in infants with acute viral bronchiolitis shortens length of hospital stay. Materials and Methods: One hundred sixty-seven patients aged 1-24 months hospitalized for treatment with a diagnosis of acute viral bronchiolitis at pediatric clinic between April 2017 and May 2018 were investigated retrospectively. The patients were divided into two separate groups, Group A (122 patients), using clarithromycin therapy during hospitalization, and Group B (45 patients), which did not receive clarithromycin (Group B). Demographic and clinical data, treatments received, and duration of hospital stay were obtained from patients’ records. Results: The rate of clarithromycin use in this study was 73%. No statistically significant difference in length of hospital stay was determined between patients receiving clarithromycin and those receiving no antibiotic therapy. However, length of hospital stay decreased with age. Clarithromycin use elicited no statistically significant decrease in hospital stay in patients with acute viral bronchiolitis. Conclusions: The routine use of clarithromycin is not recommended in acute viral bronchiolitis in the light of its cost and side-effects, and the fact is has no impact on clinical status and hospital stay

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Section: Discussionmentioning

confidence: 99%

Does Clarithromycin Use in Acute Viral Bronchiolitis Shorten Length of Hospital Stay?

Esenülkü¹,

Hancı²

2020

J. Pediatr. Acad.

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“…Several clinical studies demonstrated the ineffectiveness of macrolides and corticosteroids in infants with bronchiolitis. 19,25 Most children hospitalized due to ARTI who developed LTD were previously healthy subjects and had RSV infection.…”

Section: Discussionmentioning

confidence: 99%

Clinical and epidemiological impact of respiratory syncytial virus and identification of risk factors for severe disease in children hospitalized due to acute respiratory tract infection

et al. 2019

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Introduction: Severe acute respiratory tract infection (ARTI) is a very common cause of hospitalization in pediatrics; respiratory syncytial virus (RSV) is the major etiologic agent. Accurately defining the burden of RSV life-threatening disease (LTD) and its risk factors is a challenge. Objectives: To know the impact of RSV in children hospitalized due to ARTI and describe the risk factors for LTD. Materials and methods: Prospective study in children < 2 years old hospitalized due to ARTI during 2012-2013 at Hospital de Niños "R. Gutiérrez." LTD was defined as requiring non-invasive ventilation and/or mechanical ventilation. Results: 622 studied children, 372 were RSV(+) (59.8 %). Annual rate of hospitalization due to RSV in infants < 1 year old: 956 (95 % CI: 858-1062)/10 000 hospitalizations. RSV caused 56/78 (71.8 %) cases of LTD; 42 (75 %) were previously healthy subjects; 32 (76.2 %) were < 6 months old. In the multivariate analysis, RSV was a risk factor for LTD (adjusted odds ratio [aOR]: 2.04; 95 % CI: 1.15-3.63; p = 0.014). A differential effect by sex was identified in RSV(+) patients: overcrowding was a risk factor for LTD in males (aOR: 2.36; 95 % CI: 1.07-5.21; p = 0.033); breastfeeding was a significant protective factor in females (aOR: 0.342; 95 % CI: 0.13-0.91; p = 0.032). Conclusions: RSV caused more than half of ARTI cases and mostly affected previously healthy patients < 1 year old. Males living in overcrowding conditions and females who were not breastfed were at the greatest risk for LTD.

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“…Varios estudios clínicos demostraron la inutilidad del uso de macrólidos y corticoides en los lactantes con bronquiolitis. 19,25 La mayoría de los niños internados por IRA que desarrollaron ECV eran previamente sanos y estaban infectados por VSR.…”

Section: Discussionunclassified

Impacto clínico-epidemiológico del virus sincicial respiratorio e identificación de factores de riesgo de enfermedad grave en niños hospitalizados por infección respiratoria aguda

2019

Arch Argent Pediat

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Further clinical trials on macrolides for bronchiolitis in infants are unnecessary

Cited by 4 publications

References 7 publications

Does Clarithromycin Use in Acute Viral Bronchiolitis Shorten Length of Hospital Stay?

Does Clarithromycin Use in Acute Viral Bronchiolitis Shorten Length of Hospital Stay?

Clinical and epidemiological impact of respiratory syncytial virus and identification of risk factors for severe disease in children hospitalized due to acute respiratory tract infection

Impacto clínico-epidemiológico del virus sincicial respiratorio e identificación de factores de riesgo de enfermedad grave en niños hospitalizados por infección respiratoria aguda

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