Further characterization of theobroma oil–beeswax admixtures as lipid matrices for improved drug delivery systems

Attama, Anthony A.; Schicke, B.C.; Müller‐Goymann, Christel C.

doi:10.1016/j.ejpb.2006.06.010

Cited by 86 publications

(52 citation statements)

References 34 publications

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“…When ART was melted in it, the enthalpy value drastically reduced as the concentration of ART increased, such that the 5 mg ART-containing matrix melted at 7.563 J/g while the 10 mg ART counterpart melted at 2.031 J/g. This agrees with earlier reports that lipid matrices with a certain degree of disorder are considered to be ideal for formulation of nanoparticulate lipid carriers due to their high active ingredient payload capacity [24]. and 0.8062 J/g).…”

Section: Screening Of Lipidssupporting

confidence: 92%

“…2006 [24]. The admixtures were prepared by fusion at 90 °C for 2 h and allowed to recrystallize fully at room temperature.…”

Section: Preparation Of Binary Lipid Mixturesmentioning

confidence: 99%

“…The enthalpy of the ART-free NLC formulation was 0.075 J/g whereas those of ART-loaded NLC were 0.021, 0.038, 0.028, 0.04 J/g corresponding to 700, 500, 250 and 100 mg concentrations of ART respectively. This is most likely to have resulted from high oil content (75 % Transcutol P); hence a lower matrix crystallinity [24]. Since the thermal property was dose-independent, it implies that higher drug encapsulation efficiency would most likely occur in matrices loaded with smaller concentration of ART rather than NLC containing the highest ART loading [24,33].…”

Section: Degree Of Crystallinity and Polymorphismmentioning

confidence: 99%

“…This is most likely to have resulted from high oil content (75 % Transcutol P); hence a lower matrix crystallinity [24]. Since the thermal property was dose-independent, it implies that higher drug encapsulation efficiency would most likely occur in matrices loaded with smaller concentration of ART rather than NLC containing the highest ART loading [24,33]. In this regard therefore, the DSC result hereby agrees with and confirms the results of particle characterization (PS, PDI and ZP) by photon correlation spectroscopy as well as EE of ART which mostly favored the 250 mg ART-loading in the NLC.…”

Section: Degree Of Crystallinity and Polymorphismmentioning

confidence: 99%

“…As a result, Gelucire ® 43/01 was structured with a phospholipid, Phospholipon ® 85G (P85G 15 %) whereas the liquid lipid (Transcutol ® HP) formed 75 % of the entire matrix. High oil content of NLC has been associated with less crystallinity [24].…”

Section: Introductionmentioning

confidence: 99%

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Development of artemether-loaded nanostructured lipid carrier (NLC) formulation for topical application

Nnamani

Hansen

Windbergs

et al. 2014

International Journal of Pharmaceutics

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NLC topical formulation as an alternative to oral and parenteral (IM) delivery of artemether (ART), a poorly water-soluble drug was designed. A Phospholipon 85G-modified Gelucire 43/01 based NLC formulation containing 75 % Transcutol was chosen from DSC studies and loaded with gradient concentration of ART (100-750 mg). ART-loaded NLCs were stable (-22 to -40 mV), polydispersed (0.4 to 0.7) with d90 size distribution range of 247 to 530 nm without microparticles up to one month of storage. The encapsulation efficiency (EE %) for ART in the NLC was concentration independent as 250 mg of ART loading achieved ~61%. DSC confirmed molecular dispersion of ART due to low matrix crystallinity (0.028 J/g). Ex vivo study showed detectable ART amounts after 20 h which gradually increased over 48 h achieving ~26 % cumulative amount permeated irrespective of the applied dose. This proves that ART permeates excised human epidermis, where the current formulation served as a reservoir to gradually control drug release over an extended period of time. Full thickness skin study therefore may confirm if this is a positive signal to hope for a topical delivery system of ART.

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Section: Screening Of Lipidssupporting

confidence: 92%

“…2006 [24]. The admixtures were prepared by fusion at 90 °C for 2 h and allowed to recrystallize fully at room temperature.…”

Section: Preparation Of Binary Lipid Mixturesmentioning

confidence: 99%

Section: Degree Of Crystallinity and Polymorphismmentioning

confidence: 99%

Section: Degree Of Crystallinity and Polymorphismmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Development of artemether-loaded nanostructured lipid carrier (NLC) formulation for topical application

Nnamani

Hansen

Windbergs

et al. 2014

International Journal of Pharmaceutics

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Superhydrophobic Coatings from Beeswax‐in‐Water Emulsions with Latent Heat Storage Capability

Naderizadeh

Heredia‐Guerrero

Caputo

et al. 2019

Adv Materials Inter

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Beeswax particles are homogenously emulsified in commercial aqueous polymer dispersion, without additional dispersing agents and surfactants. Emulsions display very good stability with wax droplet size distribution around 350 nm. The wax to polymer ratio in the emulsions can be tuned without compromising emulsion stability. The emulsions are spray coated in order to create either hydrophobic or superhydrophobic coatings. For superhydrophobicity, silica nanoparticles are dispersed in the emulsions at different concentrations. Beeswax‐rich coatings such as the ones with 1:1 beeswax:polymer ratio or more, including the superhydrophobic ones, demonstrate promising latent heat storage characteristics, suitable for thermal management applications. Electron microscopy studies show that as a result of emulsification, the polymer encapsulates the wax droplets/particles as a nanothin shell, preventing a major problem related to low melting point phase change materials referred to as leaching. Hence, the coatings can be heated well above the melting point of beeswax (≈62 °C) and can still demonstrate effective heat storage during the cooling stage. This water‐based coating process using ecofriendly material constituents can easily be scaled up and used in responsive coating applications, ranging from electronics to interior or exterior structural buildings requiring efficient energy management and thermal energy savings.

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Scalable production of hydrophobic starch/beeswax films by continuous solution casting

Luchesi,

Moreira,

Marconcini

2023

J of Applied Polymer Sci

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Starch is an appealing natural polymer for the scaled‐up production of biodegradable plastics. However, the low water resistance of starch has made its broad applicability largely doubted. In this study, starch was combined with beeswax (BW) through a pilot scale continuous solution casting (CSC) technique to reduce water affinity while keeping the ensuing films totally biodegradable. The phase morphology, surface wettability, and water vapor permeability (WVP) of films were examined over a broad BW–starch mass ratio (0.3–0.7). Emulsified, surfactant‐free starch/BW films were successfully obtained at a productivity of 0.55 m2 film h−1. The water contact angle increased nearly by 100% at 30 wt% BW, leading to remarkable reductions in WVP. BW droplets well distributed within the starch matrix played a key role in enhancing the water barrier properties of films. CSC of starch/BW films offers a basis to design new hydrophobic formulations for applications that require biodegradable plastics with high moisture resistance.

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Further characterization of theobroma oil–beeswax admixtures as lipid matrices for improved drug delivery systems

Cited by 86 publications

References 34 publications

Development of artemether-loaded nanostructured lipid carrier (NLC) formulation for topical application

Development of artemether-loaded nanostructured lipid carrier (NLC) formulation for topical application

Superhydrophobic Coatings from Beeswax‐in‐Water Emulsions with Latent Heat Storage Capability

Scalable production of hydrophobic starch/beeswax films by continuous solution casting

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