Further assessment of Salvia haenkei as an innovative strategy to counteract skin photo-aging and restore the barrier integrity

Abstract

Skin is the essential barrier of the human body which performs multiple functions. Endogenous factors, in concert with external assaults, continuously affect skin integrity, leading to distinct structural changes that influence not only the skin appearance but also its various physiological functions. Alterations of the barrier functions lead to an increased risk of developing disease and side reactions, thus the importance of maintaining the integrity of the epidermal barrier and slowing down the skin aging process is evident. Salvia haenkei (SH) has been recently identified as a potential anti-senescence agent; its extract is able to decrease the level of senescent cells by affecting the IL1α release and reducing reactive oxygen species (ROS) generation. In this study, SH extract was tested on human keratinocyte cell line (HaCaT) exposed to stress factors related to premature aging of cells such as free radicals and ultraviolet B radiation. We confirmed that SH acts as scavenger of ROS and found its ability to restore the skin barrier integrity by reinforcing the cytoskeleton structure, sealing the tight junctions and increasing the migration rate of cells. Given these results, this work becomes relevant, identifying Salvia haenkei as a compound useful for anti-aging skin treatment in clinical performance.

Long Non‐coding RNA H19‐Overexpressing Exosomes Ameliorate UVB‐Induced Photoaging by Upregulating SIRT1Via Sponging miR‐138

“…Specifically, the inhibitory effects of H19‐Exo on MMPs were significantly enhanced, compared with the NC‐Exo‐treated group. SIRT1 was reported to regulate UVB‐mediated damage via the inhibition of MMPs and collagen degradation (31). Therefore, to further elucidate the targets of lncRNA H19 on miR‐138/SIRT1 axis in vivo , the expression of miR‐138 was analyzed by RT‐qPCR while SIRT1 expression was detected by immunohistochemical (IHC) and western blot assays.…”

Anti‐skin aging effect of sea buckthorn proanthocyanidins in D‐galactose‐induced aging mice

“…In addition, proanthocyanidins have shown positive effects on skin health. Due to their excellent antioxidant properties, they help reduce skin damage and inflammation and reduce wrinkles and sagging skin signs of aging, resulting in a more youthful and elastic appearance (Cocetta et al., 2021). In our previous studies, we completed the isolation and identification of Sea buckthorn proanthocyanidins (SBP) and found that it is a source of low‐molecular‐weight proanthocyanidins with good free radical scavenging ability (Zhu et al., 2021).…”

In Vitro Cultured Melissa officinalis Cells as Effective Ingredient to Protect Skin against Oxidative Stress, Blue Light, and Infrared Irradiations Damages

“…The sunlight spectrum consists of short, highenergy wavelengths, from ultraviolet radiation (280-400 nm) to visible light (400-700 nm) and infrared radiation (700 nm-1 mm), long and low energy wavelengths [9]. Visible light wavelengths penetrate the deepest parts of the dermis, reaching the different types of skin cells and inducing cell oxidative stress, damage, and dysfunction, causing signs of early photo-aging [10]. Skin is being increasingly exposed to artificial blue light due to the extensive use of electronic devices.…”