Further Aspects of T Cell Function in Systemic Lupus Erythematosus

Defreitas, M. E.; Kondracki, Esteban; Perez-Rojas, G; Bianco, N. E.

doi:10.3109/08820138209057747

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…Because our cohort of patients with SLE had predominantly quiescent disease, this may explain their normal responses to SEB. In addition, previous studies showed decreased proliferation of PBMCs (27)(28)(29), whereas others showed a normal proliferative capacity (30) or heterogeneous results (31).…”

Section: Discussionmentioning

confidence: 93%

Studies of cell‐mediated immune responses to influenza vaccination in systemic lupus erythematosus

Holvast¹,

Assen²,

Haan³

et al. 2009

Arthritis & Rheumatism

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Objective. Both antibody and cell-mediated responses are involved in the defense against influenza. In patients with systemic lupus erythematosus (SLE), a decreased antibody response to subunit influenza vaccine has been demonstrated, but cell-mediated responses have not yet been assessed. This study was therefore undertaken to assess cell-mediated responses to influenza vaccination in patients with SLE.Methods. Fifty-four patients with SLE and 54 healthy control subjects received subunit influenza vaccine. Peripheral blood mononuclear cells and sera were obtained before and 1 month after vaccination. Cellmediated responses to A/H1N1 and A/H3N2 vaccines were evaluated using an interferon-␥ (IFN␥) enzymelinked immunospot assay and flow cytometry. Antibody responses were measured using a hemagglutination inhibition test.Results. Prior to vaccination, patients with SLE had fewer IFN␥ spot-forming cells against A/H1N1 compared with control subjects and a lower frequency of IFN␥-positive CD8؉ T cells. After vaccination, the number of IFN␥ spot-forming cells increased in both patients and control subjects, although the number remained lower in patients. In addition, the frequencies of CD4؉ T cells producing tumor necrosis factor and interleukin-2 were lower in patients after vaccination compared with healthy control subjects. As expected for a subunit vaccine, vaccination did not induce a CD8؉ T cell response. For A/H3N2-specific responses, results were comparable. Diminished cell-mediated responses to influenza vaccination were associated with the use of prednisone and/or azathioprine. The increase in A/H1N1-specific and A/H3N2-specific antibody titers after vaccination was lower in patients compared with control subjects.Conclusion. In addition to a decreased antibody response, cell-mediated responses to influenza vaccination are diminished in patients with SLE, which may reflect the effects of the concomitant use of immunosuppressive drugs. This may render these patients more susceptible to (complicated) influenza infections.

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Section: Discussionmentioning

confidence: 93%

Studies of cell‐mediated immune responses to influenza vaccination in systemic lupus erythematosus

Holvast¹,

Assen²,

Haan³

et al. 2009

Arthritis & Rheumatism

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The immunopathology of systemic anergy in infectious diseases: A reappraisal and new perspectives

Bianco

1992

Clinical Immunology and Immunopathology

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Proliferative Response in Solid Culture of t Cells From Patients with Extrinsic Bronchial Asthma

Carvajal¹,

Rivas²,

Ponce³

et al. 1986

Immunological Investigations

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T cells proliferative response in both liquid and solid culture conditions (the later prevents direct cell to cell contact) was investigated in nineteen Extrinsic Bronchial Asthma patients (EBA). Tetradecanoyl-phorbol-13-acetate (TPA), a T cell mitogen was used as mitogenic stimulus in both liquid and solid conditions. While the response to phytohemaglutinin (used in liquid culture as reference) was intact, the EBA group showed a significant reduction in the proliferative response to TPA in both culture conditions. Furthermore, when adherent cells were removed prior to TPA stimulation, while the control group showed a significant decrease in proliferation, the already depressed low proliferation of the EBA group remained unchanged. These results suggest the prevalence of suppressor signals in EBA and may indicate heterogeneity of the suppressor cells pool since high levels of total serum IgE were also present in the same patients.

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Further Aspects of T Cell Function in Systemic Lupus Erythematosus

Cited by 3 publications

References 12 publications

Studies of cell‐mediated immune responses to influenza vaccination in systemic lupus erythematosus

Studies of cell‐mediated immune responses to influenza vaccination in systemic lupus erythematosus

The immunopathology of systemic anergy in infectious diseases: A reappraisal and new perspectives

Proliferative Response in Solid Culture of t Cells From Patients with Extrinsic Bronchial Asthma

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