Further analysis of the specificity of a novel animal model of depression—effects of an antihistaminic, antipsychotic and anxiolytic compound

Katz, Richard J.; Sibel, Michael

doi:10.1016/0091-3057(82)90056-9

Cited by 31 publications

(5 citation statements)

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“…For example, the behavioural changes produced by chronic variable stress or a single social defeat experience seems comparable to our present shock-induced behavioural changes (Katz et al 1981;Koolhaas et al 1990). However, the behavioural changes produced by these former stress procedures are sensitive to chronic antidepressant drug treatment in particular (Katz et al 1981;Katz and Baldrighi 1982;Katz and Sibel 1982;Koolhaas et al 1990). This may indicate that the neural origin of behavioural changes induced by chronic variable stress or social stress is different from the presently shock-induced long-term behavioural changes.…”

Section: Discussionmentioning

confidence: 96%

Effects of anxiolytic and antidepressant drugs on long-lasting behavioural deficits resulting from one short stress experience in male rats

et al. 1992

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Exposure of male Wistar rats to one single session of ten inescapable footshocks induces changes in the behavioural responses to environmental stimuli as measured in the "noise test" 14 days later. Shocked (S) rats showed decreased locomotion and rearing during the first 3 min of exposure to a novel environment compared to control (C) rats. When the 85 dB background noise was switched off a marked immobility response emerged in S rats, concomitant with a further decrease in locomotion and rearing. In response to noise off, C rats showed hardly any immobility and a much smaller reduction in locomotion and rearing compared to S rats. These long-lasting changes in behaviour were not reversed by acute treatment with the antidepressants fluvoxamine (3.0-30.0 mg/kg) and desmethylimipramine (DMI, 2.5-10.0 mg/kg) injected IP 30 min before the noise test on day 14 following the shock session. Chronic treatment (day 1 to day 14) with fluvoxamine or DMI did not reverse the behavioural deficits induced by shock exposure. Diazepam (0.6-5.0 mg/kg) administered acutely only reversed the effects of shock on locomotion during the first 3 min of the noise test. Chronic treatment with diazepam normalized the shock-induced decrease in locomotion and attenuated the rearing decrease during the first 3 min of the test, and partially restored shock-induced changes in behavioural response to switching off the noise. The most potent drug in this study was the 5-HT1A receptor agonist flesinoxan (0.3-3.0 mg/kg).(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 96%

Effects of anxiolytic and antidepressant drugs on long-lasting behavioural deficits resulting from one short stress experience in male rats

et al. 1992

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“…There are four known histamine receptors (H1R, H2R, H3R, H4R). H1R and H2R were originally studied for their role in depression, but these studies resulted in inconclusive results (Barnett et al, 1969; Horovitz et al, 1966; Katz & Sibel, 1982; Noguchi et al, 1992; O'Neill & Gertner, 1986; Wallach & Hedley, 1979; Willner, 1984). The H3R is of particular interest because it is it a presynaptic histamine autoreceptor that inhibits histamine synthesis (Arrang et al, 1987), histamine release (Arrang et al, 1987; Van der Werf et al, 1987), GABA release (Arias‐Montaño et al, 2001; Garcia et al, 1997; Yamamoto et al, 1997), NE release (Schlicker et al, 1989), 5HT release (Fink et al, 1990; Hashemi et al, 2011; Schlicker et al, 1988; Threlfell et al, 2004), and DA release (Schlicker et al, 1993).…”

Section: Monoamines Neuroinflammation and Depression: Histamine As A ...mentioning

confidence: 99%

Integrating the monoamine and cytokine hypotheses of depression: Is histamine the missing link?

Hersey

Hashemi

Reagan

2021

Eur J of Neuroscience

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Psychiatric diseases, like depression, largely affect the central nervous system (CNS). While the underlying neuropathology of depressive illness remains to be elucidated, several hypotheses have been proposed as molecular underpinnings for major depressive disorder, including the monoamine hypothesis and the cytokine hypothesis. The monoamine hypothesis has been largely supported by the pharmaceuticals that target monoamine neurotransmitters as a treatment for depression. However, these antidepressants have come under scrutiny due to their limited clinical efficacy, side effects, and delayed onset of action. The more recent, cytokine hypothesis of depression is supported by the ability of immune‐active agents to induce “sickness behaviour” akin to that seen with depression. However, treatments that more selectively target inflammation have yielded inconsistent antidepressive results. As such, neither of these hypotheses can fully explain depressive illness pathology, implying that the underlying neuropathological mechanisms may encompass aspects of both theories. The goal of the current review is to integrate these two well‐studied hypotheses and to propose a role for histamine as a potential unifying factor that links monoamines to cytokines. Additionally, we will focus on stress‐induced depression, to provide an updated perspective of depressive illness research and thereby identify new potential targets for the treatment of major depressive disorder.

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“…So far the following 18 animal models for depression in humans have been developed: (i) predatory behavior [95,96], (ii) yohimbine I potentiation [97,98], (iii) kindling [99][100][101], (iv) dopa potentiation [102,103], (v) 5-HTP-induced behavioral depression [104,105], (vi) olfactory bulbectomy [106][107][108], (vii) isolation-induced hyperactivity [109][110][111], (viii) exhaustion stress [112], (ix) circadian rhythms [113], (x) behavioral despair [114][115][116][117], (xi) chronic unpredictable stress [118][119][120][121], (xii) separation models [118,[122][123][124], (xiii) incentive disengagement [125], (xiv) intra-cranial self-stimulation [126][127][128][129][130], (xv) learned helplessness [131,132], (xvi) chronic mild stress (CMS) [133], (xvii) Swim Low-Active (SwLo) line rat [134], and (xviii) FSL rats [135].…”

Section: Animal Models For Depression and Ptsdmentioning

confidence: 99%

The β-Endorphin Role in Stress-Related Psychiatric Disorders

Merenlender‐Wagner¹,

Dikshtein²,

Yadid

2009

CDT

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Long known for its anti-nociceptive effects, the opioid beta-endorphin is also reported to have rewarding and reinforcing properties and to be involved in stress response. In this manuscript we summarize the present neurobiological and behavioral evidence regarding the role of beta-endorphin in stress-related psychiatric disorders, depression and PTSD. There is existing data that support the importance of beta-endorphin neurotransmission in mediating depression. As for PTSD, however, the data is thus far circumstantial. The studies described herein used diverse techniques, such as biochemical measurements of beta-endorphin in various brain sites and behavioral monitoring, in two animal models of depression and PTSD. We suggest that the pathways for stress-related psychiatric disorders, depression and PTSD, converge to a common pathway in which beta-endorphin is a modulating element of distress. This may occur via its interaction with the mesolimbic monoaminergic system and also by its interesting effects on learning and memory. The possible involvement of beta-endorphin in the process of stress-related psychiatric disorders, depression and PTSD, is discussed.

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Further analysis of the specificity of a novel animal model of depression—effects of an antihistaminic, antipsychotic and anxiolytic compound

Cited by 31 publications

References 5 publications

Effects of anxiolytic and antidepressant drugs on long-lasting behavioural deficits resulting from one short stress experience in male rats

Effects of anxiolytic and antidepressant drugs on long-lasting behavioural deficits resulting from one short stress experience in male rats

Integrating the monoamine and cytokine hypotheses of depression: Is histamine the missing link?

The β-Endorphin Role in Stress-Related Psychiatric Disorders

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Further analysis of the specificity of a novel animal model of depression—effects of an antihistaminic, antipsychotic and anxiolytic compound

Cited by 31 publications

References 5 publications

Effects of anxiolytic and antidepressant drugs on long-lasting behavioural deficits resulting from one short stress experience in male rats

Effects of anxiolytic and antidepressant drugs on long-lasting behavioural deficits resulting from one short stress experience in male rats

Integrating the monoamine and cytokine hypotheses of depression: Is histamine the missing link?

The &#946;-Endorphin Role in Stress-Related Psychiatric Disorders

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The β-Endorphin Role in Stress-Related Psychiatric Disorders