Further analysis of radiobiological parameters from the first and second british institute of radiology randomized studies of larynx/pharynx radiotherapy

Chappelg, Rick; Nondahl, David M.; Rezvani, M.; Fowler, Jack F.

doi:10.1016/0360-3016(95)00133-j

Cited by 19 publications

(9 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[43] Data from RTOG 83-13 (randomized Phase I-II trial, hyperfraction). [44] Data from multicenter prospective randomized clinical trials [15] Data from 2 randomized trials from the British Institute of Radiology fractionation study [23] Prospective non-randomized single-arm study [46] SEER c -Medicare linked database analysis [55] Pooled-data reports [8,9,27,45] a RT, radiotherapy b NS, non-significant. c SEER: Surveillance, Epidemiology, and End Results.…”

Section: Resultsmentioning

confidence: 99%

“…Daily (%) 0.68 [29]; 0.9/1.6 (*) [ [28] /˛2 Gy (D prolif ) g : 0.69 [23] /˛2 .5Gy (D prolif ) j : 0.64 (adjusted for stage and subsite: 0.73) [22] K h : 0.35 [17]; 0.4 [0.74 as in Withers'88) [19]; 0.56 (as in Withers'88) [7]; >0.5 [26]; 0.5-0.6 [31]; 0.6-0.8 [25]; 0.8 [15] Tk c : Lag ≤ 3 weeks [31]; 20 days [25]; 32/34 days (***) [27] LRC a in T1-2N0 glottis cancer: Try to maintain OTT k < 40-47 days [10,[16][17][18]. In any case, avoid OTT k > 60 days [33].…”

Section: Resultsmentioning

confidence: 99%

“…In any case, avoid gaps ≥3 days for LRC a and OS d [12,28] (*) ↓ 0.6%/day and 4.2%/week LRC a in hypopharynx ± larynx patients. /˛i for hypopharynx, 0.3 Gy/d (D proliff , 0.25 Gy/d) [23] (**) ↓ LC p 0.9%/day for OTT k extension as a whole and 1.6% for gaps ≥ 3 days; /˛i, 1.76 or 2.69, depending on the mathematical model used [28] (***) /˛i 1.2 or 1.63, and Tk c , 32 or 34 days, when 4 or 3 centers, respectively, are analyzed [27] The hazard rate for LCR a failure ↑ 0.067%/day of interruption [18] One NS q study showed a ↓ 12%/week LRC a (as in Fowler'92) [19] NS q lag phase; however, best estimate of Tk c is 21 days [15] Please cite this article in press as: Table 2 details the daily and weekly loss of LRC, OS, and the dose/time factor; it also outlines a series of conclusions and recommendations summarized from the literature, as well as other relevant details (discussed below). These data were used to construct Fig.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Effect of radiotherapy delay in overall treatment time on local control and survival in head and neck cancer: Review of the literature

Ferreira¹,

Olásolo²,

Azinovic³

et al. 2015

Reports of Practical Oncology & Radiotherapy

113

View full text Add to dashboard Cite

Treatment delays in completing radiotherapy (RT) for many neoplasms are a major problem affecting treatment outcome, as increasingly shown in the literature. Overall treatment time (OTT) could be a critical predictor of local tumor control and/or survival. In an attempt to establish a protocol for managing delays during RT, especially for heavily overloaded units, we have extensively reviewed the available literature on head and neck cancer. We confirmed a large deleterious effect of prolonged OTT on both local control and survival of these patients.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Effect of radiotherapy delay in overall treatment time on local control and survival in head and neck cancer: Review of the literature

Ferreira¹,

Olásolo²,

Azinovic³

et al. 2015

Reports of Practical Oncology & Radiotherapy

113

View full text Add to dashboard Cite

show abstract

“…It is well known that prolonging, or inserting time gaps into, conventional fractionated radiotherapy reduces tumor control rates unless total doses are increased 78–83. This is usually attributed to allowing more time for tumor cell proliferation 84–86.…”

Section: Comparison Of the Radiobiologic Aspects Of Fractionation Formentioning

confidence: 99%

Rationales, evidence, and design considerations for fractionated radioimmunotherapy

DeNardo

Schlom

Buchsbaum

et al. 2002

Cancer

115

View full text Add to dashboard Cite

show abstract

“…Chappell et al 102 have considered the situation of two British Institute of Radiology (BIR) trials which were conducted separately on larynx and hypopharynx patients. These trials were considered separately and the LQ model parameters determined.…”

Section: Bed=d(i+~) Al{j Biologically Effective Dose (Bed)mentioning

confidence: 99%

The use of the linear quadratic model in radiotherapy: a review

Jones

Hoban

Metcalfe

2001

Australas. Phys. Eng. Sci. Med.

View full text Add to dashboard Cite

To be able to predict the impact of any radiotherapy treatment the physics of radiation interactions and the expected biological effect for any radiotherapy treatment situation (dose, fractionation, modality) must be both understood and modelled. This review considers the current use and accuracy of the linear quadratic model which can be used to consider the variation in tissue response with fraction size. Cell kill following radiation damage results from damage to the DNA which can take a variety of forms. In many cases the linear quadratic model is used to estimate the relative impact for different situations especially clinical studies relating to fraction size. This is mainly undertaken using parameters derived from the linear quadratic model such as biological effective dose and standard effective dose. The model has also been adapted to consider the effect of overall treatment time, repair during treatment (as occurs for brachytherapy treatments) and other situations. There are some concerns over its use, mainly in the small dose ranges (both total low doses and low doses per fraction) where studies have shown its inaccuracy. In other situations however it does appear to provide a reasonable estimate of relative clinical effect. As with all models, however results should never be considered out of clinical context.

show abstract

Further analysis of radiobiological parameters from the first and second british institute of radiology randomized studies of larynx/pharynx radiotherapy

Cited by 19 publications

References 23 publications

Effect of radiotherapy delay in overall treatment time on local control and survival in head and neck cancer: Review of the literature

Effect of radiotherapy delay in overall treatment time on local control and survival in head and neck cancer: Review of the literature

Rationales, evidence, and design considerations for fractionated radioimmunotherapy

The use of the linear quadratic model in radiotherapy: a review

Contact Info

Product

Resources

About