FURTHER ANALYSIS OF INHIBITORY EFFECTS OF PROPRANOLOL AND LOCAL ANAESTHETICS ON THE CALCIUM CURRENT IN <i>Helix</i> NEURONES

Akaike, Norio; Itô, Haruo; Nishi, Katsuhide; Oyama, Yasuo

doi:10.1111/j.1476-5381.1982.tb09188.x

Cited by 48 publications

(26 citation statements)

References 20 publications

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“…However, the depressant action of local anesthetics is not exerted selectively on the Na + current. Lidocaine at clinically relevant concentrations has been shown to inhibit inward Ca 2 + currents in Helix gan-glionic neurons 102 and in frog dorsal root ganglionic cells. 1 0 3 A good correlation between local anesthetic potencies to inhibit HVA Ca 2 + currents and their anesthetic potencies implies that the inhibition of Ca 2 + influx through L/N-type VDCCs may contribute to spinal anesthesia.…”

Section: Local Anestheticsmentioning

confidence: 99%

Calcium channels — basic aspects of their structure, function and gene encoding; anesthetic action on the channels — a review

Yamakage

Namiki

2002

Can J Anesth/J Can Anesth

128

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Section: Local Anestheticsmentioning

confidence: 99%

Calcium channels — basic aspects of their structure, function and gene encoding; anesthetic action on the channels — a review

Yamakage

Namiki

2002

Can J Anesth/J Can Anesth

128

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“…On the other hand, Charles et al 18 showed that subcutaneous coadministration of verapamil and lidocaine shortened duration of local anesthesia in comparison to the lidocaine only. Propranolol demonstrates local anesthetic effect comparable to that of lidocaine by decreasing sodium and calcium influx 19 . The decrease of neuronal excitability and nociception caused by β-adrenergic receptors blockers was also proved, associated with suppression of voltage sensitive calcium and sodium channels activity reduction of intracellular cyclic adenosine monophosphate 19 levels and decrease of the adenylcyclase 20 activity.…”

Section: Discussionmentioning

confidence: 99%

The impact of cardiovascular drugs on the efficacy of local anesthesia in dentistry

Milosavljević¹,

Janković²

2016

BIOMED PAP

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Background and Aim. Drugs used chronically by patients with diseases of the cardiovascular system (group C of the ATC classification) may act on adrenergic receptors and/or certain ion channels, which gives them the potential to interact with the action of local dental anesthetics. The aim of the study was to investigate the effect of systemically administered chronic cardiovascular medication (oral route) on the efficacy of intraoral local anesthesia in patients with diseases of the cardiovascular system. Patients and Methods. This was a prospective cohort study which analyzed the efficacy of local terminal anesthesia (onset of anesthesia, duration anesthetized area) in the upper jaw of 70 patients: 40 patients on medication for cardiovascular system disorders and 30 patients who were not using these drugs (the control group). The following cardiovascular drugs were used: beta blockers, angiotensin converting enzyme inhibitors, calcium channel blockers, vasodilatators, diuretics, angiotensin receptor blockers, antiarrhythmics, statins and alfa blockers. Results. The onset of anesthesia on the vestibular side was faster in those taking cardiovascular drugs (40.50±19.87 s) than the control patients (58.93±31.07 s; P = 0.004) and duration of anesthesia on this side was shorter. Although the difference was not significant, it was evident that on vestibular and palatal side the anesthetized area was more rapidly reduced in the patients taking cardiovascular drugs. The duration of cardiovascular therapy also had a significant impact on the anesthetized area. Conclusion. Drugs acting on cardiovascular system may influence the effect of local anesthetics used in dentistry, possibly through interaction with autonomic receptors and ion channels.

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“…In 1979, Hashimoto et al (6) reported that the calcium-current of the cardiac cell was inhibited by propranolol. Furthermore, Akaike et al (7,8) observed the inhibitory action of propranolol on the calcium-current in Helix neurones. Thus, also in coronary arterial smooth muscle, it is fully expected that propranolol may impair the calcium influx.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, it has been suggested that the calcium-current of the cardiac cell (6) and the Helix neurone (7,8) is also inhibited by propranolol. Thus, propranolol has a possible inhibitory action on the calcium channel in addition to the sodium-channel.…”

mentioning

confidence: 99%

Characterization of propranolol-induced relaxation of coronary artery.

Sakanashi

Takeo

1983

Jpn.J.Pharmacol

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Abstract-Effects of propranolol on coronary artery were investigated in isolated dog coronary arteries and in isolated hearts of rats and guinea-pigs. Cumulative adminis tration of dl-propranolol produced concentration-dependent relaxation of coronary arterial strips under potassium-contracture.There was no difference in relaxant potency between the optical isomers of propranolol. Lidocaine produced less relaxation than dl propranolol, while atenolol and practolol scarecely affected the contraction. dl Propranolol-induced relaxation was significantly restored by additional calcium or prevented by prior administration of calcium. In isolated hearts of rats and guinea-pigs which were perfused at a constant coronary inflow and paced at a constant rate, bolus administration of dl-propranolol produced dose-dependent falls in coronary perfusion pressure without significant changes in myocardial contractile force. Results indicate that propranolol may have relaxant activities on coronary arteries through inhibition of calcium influx in the cell membrane of coronary arterial smooth muscle.

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FURTHER ANALYSIS OF INHIBITORY EFFECTS OF PROPRANOLOL AND LOCAL ANAESTHETICS ON THE CALCIUM CURRENT IN Helix NEURONES

Cited by 48 publications

References 20 publications

Calcium channels — basic aspects of their structure, function and gene encoding; anesthetic action on the channels — a review

Calcium channels — basic aspects of their structure, function and gene encoding; anesthetic action on the channels — a review

The impact of cardiovascular drugs on the efficacy of local anesthesia in dentistry

Characterization of propranolol-induced relaxation of coronary artery.

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