Furosemide withdrawal in elderly heart failure patients with preserved left ventricular systolic function

Kraaij, D.J.W. van; Jansen, René W. M. M.; Bouwels, Leon; Gribnau, F. W. J.; Hoefnagels, W.H.L.

doi:10.1016/s0002-9149(00)00795-5

Cited by 38 publications

(36 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…LDL initiates the chain reaction of lipid peroxidation, and forms more oxidized LDL. Oxidized LDL damages endothelial cells and their function in a variety of ways, and then promotes oxidative stress, resulting in vasomotor dysfunction [43]. O 2 - and NO react to form ONOO - .…”

Section: Degradation Of Atp and Oxidative Stressmentioning

confidence: 99%

The Molecular Mechanism of Diastolic Heart Failure

Zhao

Wang

et al. 2015

Integr Med Int

View full text Add to dashboard Cite

Diastolic heart failure (DHF) is a group of clinical syndromes related to the performance of the pulmonary circulation and systemic circulation, with normal left ventricular (LV) systolic function. The pathophysiology of diastolic dysfunction includes delayed relaxation, impaired LV filling, and/or increased stiffness. These conditions result in impaired LV diastolic relaxation ability and a decrease in myocardial compliance. In recent years, studies on the mechanisms of DHF have focused on the renin-angiotensin-aldosterone system, inflammatory cytokines, oxidative stress, the process of myocardial calcium cycling, and associated proteins. The pathomechanism has been proven to be due to a deficiency in ATP, and Ca²⁺ cannot be reduced by sarcoplasmic reticulum calcium pump (SERCA2a), which leads to myocardial diastolic dysfunction. The correlation between the degradation process of ATP and its metabolites and DHF has also been studied in recent years. This paper summarizes the views on the above and analyzes the correlations between the molecular mechanisms.

show abstract

Section: Degradation Of Atp and Oxidative Stressmentioning

confidence: 99%

The Molecular Mechanism of Diastolic Heart Failure

Zhao

Wang

et al. 2015

Integr Med Int

View full text Add to dashboard Cite

show abstract

“…Aggressive and long-term diuretic therapy may cause postprandial or orthostatic hypotension or even syncope, particularly in elderly patients with HF-PEF. Therefore, discontinuation of diuretic treatment in patients without overt clinical congestion and close monitoring of symptoms may affect hemodynamics more favorably by preserving intravascular volume and preload (230,231).…”

Section: How Should Diuretics Be Used In Hf-pef?mentioning

confidence: 99%

Practical approaches for the treatment of chronic heart failure: Frequently asked questions, overlooked points and controversial issues in current clinical practice

Çavuşoğlu

Altay²,

Ekmekçi³

et al. 2015

Anatol J Cardiol

View full text Add to dashboard Cite

Practical approaches for the treatment of chronic heart failure:Frequently asked questions, overlooked points and controversial issues in current clinical practiceHeart failure (HF) is a progressive disorder associated with impaired quality of life, high morbidity, mortality and frequent hospitalization and affects millions of people from all around the world. Despite further improvements in HF therapy, mortality and morbidity remains to be very high. The life-long treatment, frequent hospitalization, and sophisticated and very expensive device therapies for HF also leads a substantial economic burden on the health care system. Therefore, implementation of evidence-based guideline-recommended therapy is very important to overcome its worse clinical outcomes. However, HF therapy is a long process that has many drawbacks and sometimes HF guidelines cannot answers to every question which rises in everyday clinical practice. In this paper, commonly encountered questions, overlooked points, controversial issues, management strategies in grey zone and problems arising during follow up of a HF patient in real life clinical practice have been addressed in the form of expert opinions based on the available data in the literature. (Anatol J Cardiol 2015: 15 Suppl 2; 1-60)

show abstract

“…58 In diastolic heart failure, it has been suggested that volume depletion and reduced preload due to diuretics may contribute to fatigue. 59 Trial evidence to establish fatigue as an early indicator of volume depletion in systolic heart failure, and the development of postural hypotension as a late marker of this process, suggesting profound disruption of homeostatic mechanisms, is lacking.…”

Section: Fatigue and Diureticsmentioning

confidence: 99%

“…A study of people with diastolic heart failure showed no adverse outcome following withdrawal of their loop diuretic. 59 Indeed, in diastolic failure, diuretics may have an adverse effect on preload and diastolic filling. It may be that loop diuretics do not have a role in the management of patients with heart failure and normal left-ventricular function.…”

Section: Does the Patient Need Diuretics?mentioning

confidence: 99%

A review of diuretic use in older people

Laidlaw

Gillespie

2006

Rev. Clin. Gerontol.

View full text Add to dashboard Cite

Diuretics are commonly prescribed in older people and are often used for prolonged periods. Indications for their use include heart failure and hypertension. They are also used to empirically treat complaints such as swollen ankles and shortness of breath. The aging body is particularly susceptible to the adverse effects of diuretic therapy. Many of the problems are a result of intravascular and extravascular fluid imbalance. It is therefore important that diuretics are prescribed rationally and with good reason. Most major clinical trials do not include older people with multiple co-morbidities. This review will consider whether trials involving diuretics are any different, through an evaluation of what evidence there is to support diuretic use in older people. We will also evaluate the evidence which implicates diuretics as a cause of common clinical problems such as falls, postural hypotension and incontinence. Finally, a rational approach to the use of diuretics in older people will be suggested so that the benefits of diuretic therapy can be maximized and potential adverse effects minimized.

show abstract

Furosemide withdrawal in elderly heart failure patients with preserved left ventricular systolic function

Cited by 38 publications

References 18 publications

The Molecular Mechanism of Diastolic Heart Failure

The Molecular Mechanism of Diastolic Heart Failure

Practical approaches for the treatment of chronic heart failure: Frequently asked questions, overlooked points and controversial issues in current clinical practice

A review of diuretic use in older people

Contact Info

Product

Resources

About