Furosemide self nano emulsifying drug delivery system (SNEDDS) formulation comprising of capryol-90, polysorbate-80, and peg-400 with simplex-lattice-design

Abstract

Preparation of SNEDDS aims to improve solubility and absorption of furosemide in the body to reduce the dosage and minimize the side effects of drugs. Ternary diagram constructed from composition mixture produced nanoemulsion in the range of 20-40% of capryol-90, 20-40% polysorbate-80 and 40-60% PEG-400. Formulations of SNEDDS using Design-Expert ® 10 with simplex-lattice-design method in the study was aimed to investigate the effect of SNEDDS each component's proportions towards test responses. Emulsification time, drug content and viscosity were best demonstrated by run-7 with consecutive values of 131.68±2.14 seconds, 99.89±2.68% and 0.87±0.0043 mm 2 /s. The optimum formula was obtained through entering test response parameter data of all thirteen formula. Drug content and emulsification time was 107.0 ± 1.44% and 155.59±1.56 seconds with viscosity value 0.91±0.00 mm 2 /s. From the physical stability studies, SNEDDS formulas were stable and did not show phase separation when exposed to temparature stress testing.

Formulation and Evaluation of Gambier (Uncaria gambir)-Chitosan Microparticle Intranasal Delivery for Alzheimer’s Diseases

“…The solution was replaced with a phosphate buffer solution of pH 6.4 of 2 mL after each sampling to maintain sink condition. The resulting sample was analyzed using a UV-Vis spectrophotometer at catechin predetermined wavelength determined the amount of drug undergoing permeation at any given time interval (Fithri et al, 2017;Fitrya et al, 2021).…”

Solid Self Nano Emulsifying Drug Delivery System (Solid Snedds) of Mefenamic Acid: Formula Optimization Using Aerosil®-200 and Avicel® Ph-101 With Factorial Design

“…The stationary angle was calculated using Eq. 1 of flow time with an angle of repose of not more than 30°1 3 .…”

“…SNEDDS can increase the solubility of drugs with low solubility in water or generally can be classified into biopharmaceutical classification system (BCS) class II or IV. Mefenamic acid which is one of the BCS class II drugs have poor solubility will lead to poor dissolution in the gastrointestinal tract leading to delayed and limited absorption and ultimately limits its clinical effectivity [2][3][4] . Despite its clinical importance, long term use mefenamic acid is limited due to the gastrointestinal side effect it exerted, which leads to the importance on alternative strategies to reduce the dose while maintaining similar clinical outcome 5 .…”

The submicron particles FORMULATION OF IONIC-GELATION SUBMICRON PARTICLES LOADING EXTRACT PAPAYA LEAVES (Carica papaya L.) WITH LACTIC ACID ISOLATES

“…The potential diameter, polydispersity index (PDI), and zeta were measured using a particles size analysis (PSA) with the dynamic light scattering (DLS) method. The particles suspension was taken as much as 50 L and diluted 100 times to 5 mL using distilled water, then 50 L was taken and put into the cuvette PSA, then the monochromatic light was red by the instrument, the light was refracted at 90°and 173°and the detector would capture the results refraction of light to produce potential zeta data, while the results of scattering light at an angle of 90°will be captured by the detector so that it had diameter data and particle distribution (Fithri et al, 2017).…”