Furosemide potentiates the anticonvulsant action of valproate in the mouse maximal electroshock seizure model

Łuszczki, Jarogniew J.; Sawicka, Katarzyna; Kozińska, Justyna; Borowicz, Kinga K.; Czuczwar, Stanisław J.

doi:10.1016/j.eplepsyres.2007.06.010

Cited by 23 publications

(11 citation statements)

References 33 publications

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“…Acetone was administered 30 min before testing. The selected pretreatment times for the AEDs and acetone correspond to their peak anticonvulsant activity based on the available literature and our previous experiments (Luszczki et al., 2003, 2006b, 2007b; Gasior et al., 2007).…”

Section: Methodsmentioning

confidence: 99%

Pharmacodynamic and pharmacokinetic interactions between common antiepileptic drugs and acetone, the chief anticonvulsant ketone body elevated in the ketogenic diet in mice

et al. 2009

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SUMMARYPurpose: Acetone is the principal ketone body elevated in the ketogenic diet (KD), with demonstrated robust anticonvulsant properties across a variety of seizure tests and models of epilepsy. Because the majority of patients continue to receive antiepileptic drugs (AEDs) during KD treatment, interactions between acetone and AEDs may have important clinical implications. Therefore, we investigated whether acetone could affect the anticonvulsant activity and pharmacokinetic properties of several AEDs against maximal electroshock (MES)-induced seizures in mice. Methods: Effects of acetone given in subthreshold doses were tested on the anticonvulsant effects of carbamazepine (CBZ), lamotrigine (LTG), oxcarbazepine (OXC), phenobarbital (PB), phenytoin (PHT), topiramate (TPM) and valproate (VPA) against MES-induced seizures in mice. In addition, acute adverse effects of acetone-AEDs combinations were assessed in the chimney test (motor performance) and passive avoidance task (long-term memory). Pharmacokinetic interactions between acetone and AEDs were also studied in the mouse brain tissue. Results: Acetone (5 or 7.5 mmol/kg, intraperitoneally [i.p.]) enhanced the anticonvulsant activity of CBZ, LTG, PB, and VPA against MES-induced seizures; effects of OXC, PHT, and TPM were not changed. Acetone (7.5 mmol/kg) did not enhance the acute adverse-effect profiles of the studied AEDs. Acetone (5 or 7.5 mmol/kg, i.p.) did not affect total brain concentrations of the studied AEDs. In contrast, VPA, CBZ, LTG, OXC, and TPM significantly decreased the concentration of free acetone in the brain; PB and PHT had no effect. Conclusions: Acetone enhances the anticonvulsant effects of several AEDs such as VPA, CBZ, LTG, and PB without affecting their pharmacokinetic and side-effect profiles.

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Section: Methodsmentioning

confidence: 99%

Pharmacodynamic and pharmacokinetic interactions between common antiepileptic drugs and acetone, the chief anticonvulsant ketone body elevated in the ketogenic diet in mice

et al. 2009

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“…Furosemide reduces the clearance of theophylline, other organic acids, and gentamicin [76, 77]. It reduces the therapeutic effect of warfarin [78], but increases the hypokalaemic effect of amphotericin, the anti‐epileptic effect of sodium valproate the [79], the hypotensive and renal effect of angiotensin‐converting‐enzyme inhibitors [80], and the risk from ototoxicity from aminoglycosides and vancomycin (Table 4) [60]. The specific considerations for intra‐operative use of furosemide by anaesthetists are described in Table 5.…”

Section: Potential Pitfalls Of Using Furosemidementioning

confidence: 99%

Benefits and risks of furosemide in acute kidney injury

Power²

2010

Anaesthesia

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SummaryFurosemide, a potent loop diuretic, is frequently used in different stages of acute kidney injury, but its clinical roles remain uncertain. This review summarises the pharmacology of furosemide, its potential uses and side effects, and the evidence of its efficacy. Furosemide is actively secreted by the proximal tubules into the urine before reaching its site of action at the ascending limb of loop of Henle. It is the urinary concentrations of furosemide that determine its diuretic effect. The severity of acute kidney injury has a significant effect on the diuretic response to furosemide; a good

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“…Principally, the maximal electroshock seizure test (MES), as a mean of electro-shock inducing convulsions, reflecting the generalized tonic-clonic (grand mal) type of epileptic seizures, was adopted (20) . The method was reported as, probably, the best validated for evaluating of antiepileptic drugs (18,19) .…”

Section: -Lsd Test (Vis-à-vis Valproic Acid)mentioning

confidence: 99%

Synthesis and Investigation of 2-Propylpentanoyl Amino Acid and Dipeptide Conjugates as Novel Anticonvulsants

2010

Egypt. J. Chem.

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Furosemide potentiates the anticonvulsant action of valproate in the mouse maximal electroshock seizure model

Cited by 23 publications

References 33 publications

Pharmacodynamic and pharmacokinetic interactions between common antiepileptic drugs and acetone, the chief anticonvulsant ketone body elevated in the ketogenic diet in mice

Pharmacodynamic and pharmacokinetic interactions between common antiepileptic drugs and acetone, the chief anticonvulsant ketone body elevated in the ketogenic diet in mice

Benefits and risks of furosemide in acute kidney injury

Synthesis and Investigation of 2-Propylpentanoyl Amino Acid and Dipeptide Conjugates as Novel Anticonvulsants

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