Furosemide Determination by First‐Derivative Spectrophotometric Method

Dias, Iara Lúcia Tescarollo; Martins, Jorge Luiz Seferin; Neto, Graciliano de Oliveira

doi:10.1081/al-200057227

Cited by 15 publications

(2 citation statements)

References 28 publications

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“…The literature review shows that BIS and CAR were determined with other drugs using spectrophotometric [6–8, 13] and high‐performance liquid chromatography (HPLC) techniques [9–12, 14–16]. Also FUR was determined by spectrophotometric techniques [17–219] and HPLC techniques [20–23].…”

Section: Introductionmentioning

confidence: 99%

The improvement of routine drug quality control analysis of some antihypertensive drugs using high‐performance thin‐layer chromatography densitometry method with greenness profile evaluation

Abdelhamid,

Abdelaleem,

Lashien

et al. 2023

J of Separation Science

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The common antihypertensive drugs are B‐blockers and diuretics. For the determination of beta‐blocker medicines (bisoprolol fumarate and carvedilol) and diuretic drug (Furosemide), new and accurate chromatographic method has been developed. The separation was achieved using a developing system that includes chloroform:methanol:ethyl acetate:ammonia (6:2:2:0.2 by volume) as a mobile phase and the bands were detected at 240 nm. The concentration ranges were 5–25, 1–7, and 1–3.5 μg/band for bisoprolol fumarate, carvedilol, and furosemide, respectively. This chromatographic approach is the first methodology for simultaneously determining bisoprolol fumarate, carvedilol, and furosemide in their pure forms and in their pharmaceutical dosage forms. The advantages of using known analytical procedures are their simplicity, speed, cost effectiveness, lack of laboriousness, and ability to save time as the three tablets are determined in one step and can be used for routine analysis of the investigated combinations in quality control laboratories. According to International Conference of Harmonization guidelines, the established procedures have been validated, and the results were statistically compared to those obtained by the reported reversed‐phase–high‐performance liquid chromatography methods using Student's t‐test and F‐test, with no significant difference between them, indicating that the proposed methods can be used for routine drug quality control analysis.

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Section: Introductionmentioning

confidence: 99%

The improvement of routine drug quality control analysis of some antihypertensive drugs using high‐performance thin‐layer chromatography densitometry method with greenness profile evaluation

Abdelhamid,

Abdelaleem,

Lashien

et al. 2023

J of Separation Science

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show abstract

“…Several analytical methods for determination of both drugs were revealed through the literature survey. FR has been determined by various methods such as spectrophotometry (Gölcü, ; Semaan & Cavalheiro, ; Semaan, de Sousa, & Cavalheiro, ; Tescarollo Dias, Martins, & de Oliveira Neto, ), thin‐layer chromatography (TLC) (Mikkelsen & Andreasen, ), spectrofluorimetry (El‐Wasseef, El‐Sherbiny, Abu‐El‐Enein, & El‐Ashry, ; Peralta, Fernández, & Masi, ) and high‐performance liquid chromatography (HPLC) (Andreasen, Christensen, Jakobsen, & Mogensen, ; Guzmán, Agüı́, Pedrero, Yáñez‐Sedeño, & Pingarrón, ; Huclová et al, ; Semaan, dos Santos Neto, Lanças, & Gomes Cavalheiro, ), while, SP was determined by spectrophotometry (ERK, ; Prajapati, Chandarana, & Modi, ), chemometry/UV (Dinç & Üstündağ, ), TLC (Hegazy, Metwaly, Abdelkawy, & Abdelwahab, ) and HPLC (Hegazy et al, ). A binary mixture of both drugs was determined by spectrophotometric (Millership, Parker, & Donnelly, ) and HPLC methods (Ram, Dave, & Joshi, ).…”

Section: Introductionmentioning

confidence: 99%

Development and validation of HPTLC and green HPLC methods for determination of furosemide, spironolactone and canrenone, in pure forms, tablets and spiked human plasma

Naguib

Abdelaleem

Emam

et al. 2018

Biomedical Chromatography

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Two selective and accurate chromatographic methods are presented for simultaneous quantitation of spironolactone (SP) and furosemide (FR) and canrenone (CN), the main degradation product and the main active metabolite of SP. Method A was HPTLC, where separation was completed on silica gel HPTLC F plates using ethyl acetate-triethylamine-acetic acid (9:0.7:0.5, by volume) as a developing system and UV detection at 254 nm. Method B was a green isocratic RP-HPLC utilizing a C (4.6 × 100 mm) column, the mobile phase consisting of ethanol-deionized water (45: 55, v/v) and UV estimation at 254 nm. Adjustment of flow rate at 1 mL/min and pH at 3.5 with glacial acetic acid was done. Regarding the greenness profile, the proposed RP-HPLC method is greener than the reported one. ICH guidelines were followed to validate the developed methods. Successful applications of the developed methods were revealed by simultaneous determination of FR, SP and CN in pure forms and plasma samples in the ranges of 0.2-2, 0.05-2.6 and 0.05-2 μg/band for method A and 5-60, 2-60 and 2-60 μg/mL for method B for FR, SP and CN, respectively.

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A Graphite‐Polyurethane Composite Electrode for the Analysis of Furosemide

et al. 2008

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A graphite-polyurethane composite electrode has been used for the determination of furosemide, a antihypertensive drug, in pharmaceutical samples by anodic oxidation. Cyclic voltammetry and electrochemical impedance spectroscopy were used to characterize the electrooxidation process at þ 1.0 V vs. SCE over a wide pH range, with the result that no adsorption of analyte or products occurs, unlike at other carbon-based electrode materials. Quantification was carried out using cyclic voltammetry, differential pulse voltammetry, and square-wave voltammetry. Linear ranges were determined (up to 21 mmol L À1 with cyclic voltammetry) as well as limits of detection (0.15 mmol L À1 by differential pulse voltammetry). Four different types of commercial samples were successfully analyzed. Recovery tests were performed which agreed with those obtained by spectrophotometric evaluation. The advantages of this electrode material for repetitive analyzes, due to the fact that no electrode surface renewal is needed owing to the lack of adsorption, are highlighted.

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Furosemide Determination by First‐Derivative Spectrophotometric Method

Cited by 15 publications

References 28 publications

The improvement of routine drug quality control analysis of some antihypertensive drugs using high‐performance thin‐layer chromatography densitometry method with greenness profile evaluation

The improvement of routine drug quality control analysis of some antihypertensive drugs using high‐performance thin‐layer chromatography densitometry method with greenness profile evaluation

Development and validation of HPTLC and green HPLC methods for determination of furosemide, spironolactone and canrenone, in pure forms, tablets and spiked human plasma

A Graphite‐Polyurethane Composite Electrode for the Analysis of Furosemide

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