Furochinoline alkaloids in plants from Rutaceae family – a review

Abstract

Over the past five years, phytochemical and pharmacological studies have been conducted on material extracted from members of the Rutaceae family. In such work, new furochinoline-structured alkaloids were isolated from Ruta sp. and Dictamnus sp. Beyond the aforementioned, other substances with promising activity were isolated from the less-known species of Zanthoxylum, Evodia, Lonchocarpus, Myrthopsis and Teclea. Currently used forms of extraction, as well as methods of isolation and detection, allow the obtaining of pure, biologically active compounds. Many of these have antifungal, anti-bacterial and anti-plasmodial properties. Others are still being researched as potential drugs, which, in future, may be used in treating those afflicted with HIV and cancer. This article is designed to give the readers a thorough review of the active natural products from the Rutaceae family.

Phytochemistry and Ethnopharmacology of Vebris nobilis Delile (Rutaceae)

“…There are several quinoline, furoquinoline and acridone alkaloids identified in the different plant parts. For instance, furoquinoline alkaloids; tecleabine [18], tecleoxine [7], isotecleoxine [19], methylnkolbisine [5], chlorodesnkolbisine [20], pteleine [21], isohaplopine-3,3-dimethylallylether [22], nobiline [23] haplopine-3,3-dimethylallylether [24] anhydroevoxine [9], kokusaginine [12] and 8-methoxyflindersine [25]; and acridone alkaloid, arborinine [26] were isolated from the aerial parts of V. nobilis [4,5].…”

Maculine: a furoquinoline alkaloid from the family Rutaceae: sources, syntheses and biological activities

“…33 Esenbeckia leiocarpa (Rutaceae), popularly known as guarantã, goiabeira, a native tree of Brazil, afforded maculine. 16 Another plant of family Rutaceae, Oricia suaveolens expressed maculine in the stems and leaves extract. This plant could be found in the Democratic Republic of the Congo, Ivory Coast, Ghana, Guinea, Nigeria, and Sierra Leone.…”

“…[9][10][11] The main furoquinoline alkaloid compounds isolated from this family are dictamnine (1), skimmianine (2), γ-fagarine (3), haplopine (4), 7-hydroxydictamine (5), evolitrine (6), maculosidine (7), maculine (8), flindersiamine (9), tecleaverdoornine (10), leptanoine A (11), leptanoine B (12), leptanoine C (13), melineurine (14), kokusaginine (15), acronycidine (16), tecleamaniensine A (17), tecleamaniensine B (18), acronydine (19), isohaplopine (20 (22), isomaculosidine (23), iso-γ-fagarine (24), dictangustine A (25), isopteleine (26), isoskimmianine (27), isokokusaginine ( 28), (+) isoplatydesmine ( 29), (+)-araliopsine (30), balfourodine (31), pseudobalfourodine (32), dihydroisodictamnine (33), dihydrodictamnine (34), evoxine (35), isoevoxine (36). [12][13][14][15][16][17] (Figure 1) Many of these compounds have antifungal, anti-bacterial, anti-Alzheimer, antiplasmodial and phototoxic properties. [18][19][20][21][22] Some of the others represent a promising perspective of being potential drugs.…”

Chemical Composition, Antioxidant Potential and Antimicrobial Properties of the Essential Oils of Haplophyllum tuberculatum (Forsskal) A. Juss from Morocco

“…This species is one of 2100 species grouped into 154 genera composed of trees, shrubs and aromatic herbs mainly tropical and subtropical 5 .This family is a potential source of many medicinal substances. 6 H. tuberculatum grows on sandy hills and rocky slopes of arid regions, it extends from Morocco to the west of Pakistan, 7 it has shown great variability in its traditional uses depending on geographic and ecological location. 8 According to Hadjadj et al, 9 H. tuberculatum was traditionally used as an antiseptic, calming, for infertility, treatment of diabetes, against fever, bloating, diarrhea, flu, scorpion © 2020 the authors.…”