Furanones as potential anti-bacterial coatings on biomaterials

Baveja, J.K; Willcox, Mark; Hume, Emma B.H.; Kumar, Naresh; Odell, Ross A.; Poole-Warren, Laura A.

doi:10.1016/j.biomaterials.2004.02.051

Cited by 165 publications

(89 citation statements)

References 41 publications

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“…Flushing should be considered as a warning sign of a potential cardiovascular instability [10,26]. It responds to a bolus of octreotide.…”

Section: Common Complications During Intraoperative Periodmentioning

confidence: 99%

Perioperative Management of Carcinoid Syndorme-An Anaesthesiologist’s Perspective

Mvs¹

2016

J Anesth Clin Res

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Occurrence of carcinoid syndrome is very rare. So the expertise and literature on this syndrome is limited. Physiologically active substances that are secreted by the carcinoid tumour cause major problems for the anesthesiologist in the perioperative period. Preoperative preparation of the patient is the most important step that decides the recovery of the patient. Discovery of octreotide lead to the improvement in treating and decreasing the morbidity and mortality during surgery. If the surgery is palliative post-operative management also makes it difficult for the anesthesiologist. Extreme vigilance and common sense had to be applied during the surgery by the anesthesiologist. Pathophysiology, symptomatology, diagnosis and perioperative management are described in this article.

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“…Flushing should be considered as a warning sign of a potential cardiovascular instability [10,26]. It responds to a bolus of octreotide.…”

Section: Common Complications During Intraoperative Periodmentioning

confidence: 99%

Perioperative Management of Carcinoid Syndorme-An Anaesthesiologist’s Perspective

Mvs¹

2016

J Anesth Clin Res

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“…An arbitrary value of 0.7 was used as an indicator in this assay for assessing the "acceptable level" of cell inhibition [29,30]. A comparison between PU and PUNCs fabricated either as films or coatings is shown in Figure 3.…”

Section: Cell Growth Inhibition (Cgi)mentioning

confidence: 99%

“…CGI was expressed as a ratio of the number of cells in test material to the number of cells in PU control. A ratio of 0.7 or higher was considered an 'acceptable level' of cell growth inhibition within this assay [29,30]. Materials were performed in triplicates and the assay was repeated in triplicates.…”

Section: Cell Growth Inhibition (Cgi) Assaymentioning

confidence: 99%

Polyurethane Organosilicate Nanocomposites as Blood Compatible Coatings

et al. 2012

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Polymer clay nanocomposites (NCs) show remarkable potential in the field of drug delivery due to their enhanced barrier properties. It is hypothesised that well dispersed clay particles within the polymer matrix create a tortuous pathway for diffusing therapeutic molecules, thereby resulting in more sustained release of the drug. As coatings for medical devices, these materials can simultaneously modulate drug release and improve the mechanical performance of an existing polymer system without introducing additional materials with new chemistries that can lead to regulatory concerns. In this study, polyurethane organosilicate nanocomposites (PUNCs) coated onto stainless steel wires were evaluated for their feasibility as blood compatible coatings and as drug delivery systems. Heparin was selected as the model drug to examine the impact of silicate loading and modifier chain length in modulating release. Findings revealed that better dispersion was achieved from samples with lower clay loadings and longer alkyl chains. The blood compatibility of PUNCs as assessed by thrombin generation assays showed that the addition of silicate particles did not significantly decrease the thrombin generation lag time (TGT, p = 0.659) or the peak thrombin (p = 0.999) of polyurethane (PU). PUNC coatings fabricated in this research were not cytotoxic as examined by the cell growth inhibition OPEN ACCESSCoatings 2012, 2 46 assay and were uniformly intact, but had slightly higher growth inhibition compared to PU possibly due to the presence of organic modifiers (OM). The addition of heparin into PUNCs prolonged the TGT, indicating that heparin was still active after the coating process. Cumulative heparin release profiles showed that the majority of heparin released was from loosely attached residues on the surface of coils. The addition of heparin further prolonged the TGT as compared to coatings without added heparin, but a slight decrease in heparin activity was observed in the NCs. This was thought to be from competitive interactions between clay-heparin that influenced the formation of the ternary complex between heparin, ATIII thrombin. In summary, the feasibility of using PUNC as drug delivery coatings was shown by the good uniformity in the coating, absence of by-products from the coating process, and the release of active molecules without significantly interfering with their activity.

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“…9 They are structurally similar to bacterial N-acyl homoserine lactones (AHLs), which participate in cell-to-cell communication to control swarming and biofilm formation in various microbial species. 10 Thus, halogenated furanones acting as AHL antagonists have negative impacts on bacterial colonization.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial activity and biological performance of a novel antibacterial coating containing a halogenated furanone compound loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium

Cheng¹,

Zhao²,

Liu³

et al. 2015

IJN

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Titanium implants have been widely used for many medical applications, but bacterial infection after implant surgery remains one of the most common and intractable complications. To this end, long-term antibacterial ability of the implant surface is highly desirable to prevent implant-associated infection. In this study, a novel antibacterial coating containing a new antibacterial agent, (Z-)-4-bromo-5-(bromomethylene)-2(5H)-furanone loaded poly(L-lactic acid) nanoparticles, was fabricated on microarc-oxidized titanium for this purpose. The antibacterial coating produced a unique inhibition zone against Staphylococcus aureus throughout a 60-day study period, which is normally long enough to prevent the infection around implants in the early and intermediate stages. The antibacterial rate for adherent S. aureus was about 100% in the first 10 days and constantly remained over 90% in the following 20 days. Fluorescence staining of adherent S. aureus also confirmed the excellent antibacterial ability of the antibacterial coating. Moreover, in vitro experiments showed an enhanced osteoblast adhesion and proliferation on the antibacterial coating, and more notable cell spread was observed at the early stage. It is therefore concluded that the fabricated antibacterial coating, which exhibits relatively long-term antibacterial ability and excellent biological performance, is a potential and promising strategy to prevent implant-associated infection.

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Furanones as potential anti-bacterial coatings on biomaterials

Cited by 165 publications

References 41 publications

Perioperative Management of Carcinoid Syndorme-An Anaesthesiologist’s Perspective

Perioperative Management of Carcinoid Syndorme-An Anaesthesiologist’s Perspective

Polyurethane Organosilicate Nanocomposites as Blood Compatible Coatings

Antibacterial activity and biological performance of a novel antibacterial coating containing a halogenated furanone compound loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium

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