Furan derivatives their common molecular denominator responsible for bleaching of Euglena gracilis

Hyperthermia and other factors increasing sensitivity of Euglena to mutagens and carcinogens

“…In studies including an extensive collection of 90 furan derivatives, it was found that the nitro group in position 5 of the furan ring is responsible for their mutagenicity in bacterial systems [18]. The same also holds true for the bleaching effect of furan derivatives [7][8][9]11,12]. The dynamics of the induction of bleached colonies of E grucilis indicates that NV and NFAA resemble the tested supermutagens with respect to their mechanism of action, and therefore, it appears highly desirable to revalue their practical application with respect to possible health risk.…”

“…This hereditary bleaching of Euglena gracils was shown to be caused by physical factors such as elevated temperature [30], UV radiation [22], and chemical compounds such as antibiotics [4-7, lo], nitrofurans [8,9,[11][12][13][14][15][16][17][18]23,24], nitrosoguanidine and related compounds [ 11,25,26], and other factors as well. The hereditary bleaching results in a conversion of original green colonies to apochlorotic white ones, and hence, the detection of this phenomenon is very simple.…”

Are Plastids Derived from Prokaryotic Micro-organisms? Action of Antibiotics on Chloroplasts of Euglena gracilis

“…However, in 1961 we observed that erythromycin exerted the same effect as streptomycin (Ebringer, I 96 I). Subsequently other antibiotics have been discovered which induce permanent loss of chloroplasts in Euglena (Ebringer, 1962a(Ebringer, , b, c, 1964(Ebringer, , 1966(Ebringer, , 1971Ebringer, Krkoska, MaEor, JurASek & Kada, 1967;Ebringer, Mego, JurASek & Kada, 1969;Zahalsky, Hutner, Keane & Burger, 1962;McCalla, 1962McCalla, , 1965Celmer & Ebringer, 1967;Lyman, 1967;McCalla & Baerg, 1969).…”

Different growth response of Euglena gracilis to Hg, Cd, Cr and Ni compounds

“…After exposure the cells were diluted in a ratio of 1 : 1 -1 : 100 with sterile water and spread on agar plates containing Cramer-Myers' medium and 1.2% Bacto agar Difco. As a positive control the bleaching effect of the nitrovin -1,5-bis (5-nitro-2-furyl)-1,4 -pentadiene-3-on aminohydrazone hydrochloride according to Ebringer et al [7] was used. The quality of the colonies was evaluated after 15 days of cultivation at 26 ± 2°C under permanent illumination in order to detect white colonies.…”