Funktionelle Substitutionen am Insulinmolekül

Losse, Günter; Mützler, Gudrun

doi:10.1002/zfch.19810211104

Cited by 2 publications

(1 citation statement)

References 39 publications

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“…Using their approach, the authors were able to study the binding site 196 and to obtain crystalline derivatives of modified bovine insulin, 197 which is especially hard to crystallize without inducing structural changes. 198 A similar protocol was used by Ladd et al 199 for chromophorical PEGylation of proteins with polyethylene glycol fluoronitrobenzene derivatives.…”

Section: Alain Wagnermentioning

confidence: 99%

Developments and recent advancements in the field of endogenous amino acid selective bond forming reactions for bioconjugation

2015

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Bioconjugation methodologies have proven to play a central enabling role in the recent development of biotherapeutics and chemical biology approaches. Recent endeavours in these fields shed light on unprecedented chemical challenges to attain bioselectivity, biocompatibility, and biostability required by modern applications. In this review the current developments in various techniques of selective bond forming reactions of proteins and peptides were highlighted. The utility of each endogenous amino acid-selective conjugation methodology in the fields of biology and protein science has been surveyed with emphasis on the most relevant among reported transformations; selectivity and practical use have been discussed.

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Section: Alain Wagnermentioning

confidence: 99%

Developments and recent advancements in the field of endogenous amino acid selective bond forming reactions for bioconjugation

2015

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Synthese von B1‐substituierten Peptidyl‐Insulinen

Losse

Raddatz

1987

J. Prakt. Chem.

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Synthesis of B1 Substituted Peptidyl Insulins The peptide derivatives Boc‐Leu‐Tyr(Bzl)‐Gln‐Leu‐OH of the sequence section 13–16 of the insulin A chain and Boc‐Leu‐Tyr(Bzl)‐Leu‐Val‐Cys(SEt)‐Gly‐OH corresponding to the partial sequence 15–20 of the B chain are condensated with A1, B29‐Boc 2 ‐insulin via their pentachlorphenylesters. After removal of the protecting groups by HBr/TFA in the presence of anisole and ethylmercaptan the corresponding insulins elongated in position B1 are isolated and characterized by HPLC.

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Funktionelle Substitutionen am Insulinmolekül

Cited by 2 publications

References 39 publications

Developments and recent advancements in the field of endogenous amino acid selective bond forming reactions for bioconjugation

Developments and recent advancements in the field of endogenous amino acid selective bond forming reactions for bioconjugation

Synthese von B1‐substituierten Peptidyl‐Insulinen

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