Funkcjonalne polimorfizmy genów leptyny i receptora leptyny korelują z długowiecznością oraz z ryzykiem zawału mięśnia serca i cukrzycy 2 typu

Abstract

Introduction: Longevity is commonly associated with good health and with delayed onset of age-related diseases with usually benign course. Leptin (LEP) significantly affects metabolism and numerous functions of the organism. To find out if extreme longevity and its phenotype are associated with genetic variants of leptin and leptin receptor (LEPR) genes, we analysed the frequencies of the -2548 G/A and +19 G/A LEP, as well as the K109R, Q223R, and K656N LEPR polymorphisms in centenarians and in control groups.

Leptin Receptor Gene Polymorphism and the Risk of Cardiovascular Disease: A Systemic Review and Meta-Analysis

“…We further excluded 156 articles by reading the title and the abstract of each article, and the remaining 22 full-text articles were assessed for eligibility. Finally, a total of 7 studies were included in the present study [10,11,12,18,19,20,21]. …”

“…The published year of these articles ranged between 2009 and 2015. One of the included articles was conducted in Egyptian subjects [10], two studies were performed in Chinese subjects [12,20], three studies were performed in European [18,21] and American subjects [11], and the other one study was performed in both European and Asian subjects [19]. All articles included both male and female participants.…”

“…All the outcome variables were assessed by clinical diagnosis or hospital registration. Six studies reported the outcome of heart disease [10,11,18,19,20,21], and one study reported the risk of ischemic stroke [12]. Four LEPR gene polymorphism loci were included in the present analysis.…”

“…Four LEPR gene polymorphism loci were included in the present analysis. Five, three, two, and two studies reported the LEPR gene polymorphism of rs1137101 (Gln223Arg) [10,11,12,18,21], rs1137100 (Lys109Arg) [12,18,21], rs6700896 [19,20], and rs8179183 (Lys656Asn) [12,21], respectively. Genotyping of the polymorphisms in LEPR was carried out by the polymerase chain reaction (PCR)-restriction fragment length polymorphism method (RFLP) [10,11,12,18,20,21], or genome-wide association scan [19].…”

“…Only two included studies were of cohort design [18,19]. Two studies did not provide information of the eligibility criteria [18,21]. Three studies did not adjust other potential confounders except for age and gender [10,12,20], and one study did not adjust for any confounding variables [21].…”