Fungsi Ginjal  Pasien Thalassemia Mayor yang Mendapatkan Kelasi Besi Oral

Sari, Teny Tjitra; Swity, Aulia Fitri; Sjakti, Hikari Ambara; Hidayati, Eka Laksmi; Sari, Dian Puspita

doi:10.14238/sp20.4.2018.242-8

Cited by 4 publications

(7 citation statements)

References 5 publications

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“…24 Sari et al also reported a decrease in eFLG in patients receiving oral iron chelation therapy. 9 Decreased eGFR can occur due to chronic anemia, iron overload, and the use of certain This electrolyte imbalance can cause muscle weakness, cramps, and heart problems. Glomerular hyperfiltration and decreased eGFR can lead to chronic renal failure, which is a serious and lifethreatening condition.…”

Section: Discussionmentioning

confidence: 99%

“…7,8 Clinical studies show varying degrees of tubular dysfunction and glomerular filtration rate abnormalities are common findings in βthalassemia patients. 9 Chronic anemia, iron overload, and the use of iron chelation are thought to be related to the manifestation of kidney disorders. 10 Impaired kidney function can occur without symptoms and before serious manifestations appear, so early markers are needed to detect kidney damage.…”

Section: Introductionmentioning

confidence: 99%

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Estimated Glomerular Filtration Rate in Pediatric Patients with β-Thalassemia Major: A Single-Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia

Vania Ilmi Basri,

Husni,

Desiekawati

2024

Bioscmed

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Background: Patients with β-thalassemia major can experience impaired kidney function. Impaired kidney function can occur without symptoms and before serious manifestations appear, so early markers are needed to detect kidney damage. Estimated glomerular filtration rate (eGFR) is a calculation to detect early impairment of kidney function and is widely accepted as an indicator in determining overall kidney function. This study aims to determine the estimated glomerular filtration rate in pediatric patients with β-thalassemia major. Methods: This research is a descriptive research. Data was taken from pediatric patients with β-thalassemia major who received routine transfusions at the pediatric polyclinic of Dr. M. Djamil General Hospital Padang from January 1st – July 31st 2023. Patients underwent hematology examination, serum ferritin, serum creatinine, and estimated glomerular filtration rate calculations using the Schwartz formula. Results: A total of 55 children met the research criteria, consisting of 27 boys (49%) and 28 girls (51%). The median serum creatinine level was 0.5 (0.3-0.8) mg/dL with a range with a mean estimated glomerular filtration rate of 167 mL/minute/1.73m2. Conclusion: Glomerular hyperfiltration occurs in the majority of β-thalassemia major patients, but a decrease in

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Estimated Glomerular Filtration Rate in Pediatric Patients with β-Thalassemia Major: A Single-Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia

Vania Ilmi Basri,

Husni,

Desiekawati

2024

Bioscmed

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“…Indonesia termasuk negara dengan tingkat kejadian talasemia tingg, bukan hanya dilihat dari jumlah pasien, tapi juga dilihat dari frekuensi kelainan gen yang ditemukan. Pada tahun 2018, Rumah Sakit Cipto Mangunkusumo mencatat 666 asien kasus talasemia (Sari et al, 2018).…”

Section: Pendahuluanunclassified

Hubungan Antara Tingkat Pendidikan dan Pengetahuan Orangtua dengan Kualitas Hidup Anak Talasemia Mayor di RSUD Dr. M. Yunus Bengkulu Tahun 2017

Faraski,

Rohima,

Rianissa Putri

2023

SLJIL

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One of the problem in thalassemia children is poor quality of life. It is assessed through 4 functions, namely physical, emotional, social, and school functions. Many factors affect the quality of life in thalassemia patients. This study is aimed to know the relationship between educational level and knowledge of parents, with the quality of life in thalassemia children. A cross-sectional study with 54 subjects with thalassemia and 54 pairs of parents. Subjects who met the inclusion criteria and did not meet the exclusion criteria were taken by the consecutive sampling method. Data collection technique was done by conducting interviews based on characteristic data questionnaires, parental knowledge questionnaires, and quality of life questionnaires using PedsQL 4.0 Core Scales. We analised the data by Spearman correlation test and Pearson correlation test. Maternal’s educational level has a significant correlation to the quality of life in children with thalassemia with moderate correlation strength on spearman test (r = 0,410; p = 0,002). Father’s educational level has a significant correlation to the quality of life in the children with thalassemia with a weak correlation strength (r = 0.359; p = 0.008) on the spearman test. Maternal’s level of knowledge have significant correlation to the quality of life in children with thalassemia with medium correlation strength (r = 0,404; p = 0,002) on spearman test. Father’s level of knowledge have significant correlation to quality of life in children with thalassemia with weak correlation strength (r = 0,335; p = 0,013) on the spearman test. Multivariate test found that most factors affecting the quality of life of children with thalassemia is the level of knowledge of mothers with p = 0.014 and OR = 1.179. There is a significant correlation between the level of education and knowledge of parents on the quality of life of major thalassemia children.

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“…Hal ini sejalan dengan penelitian Teny dkk. 5 Peningkatan LFG dapat merupakan gejala awal yang disebut hiperfiltrasi. Hiperfiltrasi dapat mengakibatkan perengangan dinding kapiler dan kerusakan epitel glomerulus sehingga dapat terjadi penurunan LFG yang progresif.…”

Section: Pembahasanunclassified

“…Pada tahun 2018, Rumah Sakit Cipto Mangunkusumo mencatat 666 pasien kasus talasemia. 5 Tingkat kelangsungan hidup pasien talasemia telah meningkat, terutama di negara-negara dengan sumber daya kesehatan yang memadai dan pengobatan yang sesuai. Terapi melalui transfusi darah serta pengendalian zat besi dengan metode tepat waktu telah meningkatkan harapan hidup anak-anak yang mengidap talasemia.…”

unclassified

Fungsi Ginjal Pasien Talasemia Beta Mayor yang Menggunakan Kelasi Besi Oral di Rumah Sakit Umum Zainoel Abidin Banda Aceh

Mailani,

Haris,

Noviat

et al. 2023

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Latar belakang. Penderita talasemia beta mayor yang mendapatkan transfusi darah berulang dapat menyebabkan penumpukan besi, sehingga diperlukan pemberian kelasi besi. Deferasirox dan deferipron merupakan agen kelasi besi oral yang umum digunakan. Kelasi besi oral dapat menyebabkan gangguan fungsi ginjal.Tujuan. Untuk mengetahui fungsi ginjal penderita talasemia beta mayor yang menggunaan kelasi besi oral.Metode. Penelitian ini menggunakan data sekunder (rekam medis) selama rentang waktu November 2022 hingga Januari 2023 dengan desain potong lintang. Sampel penelitian pasien talasemia beta mayor anak yang mendapatkan terapi kelasi besi oral berdasarkan kriteria inklusi dan eksklusi. Hasil. Analisis 51 anak talasemia beta mayor yang memenuhi kriteria inklusi dengan rata-rata Laju Filtrasi Glomerulus yang mendapat terapi kelasi oral deferasirox dan deferipron berturut-turut adalah 168,51±27,80 mL/min/1,73m2 dan 187,26±29,97 mL/min/1,73m2. Perbandingan pada kedua kelompok secara statistik terdapat perbedaaan bermakna dengan p=0,025. Kesimpulan. Terdapat perbedaan signifikan dari Laju Filtrasi Glomerulus pada kedua kelompok kelasi besi oral, tetapi tidak didapatkan terjadinya penurunan fungsi ginjal pada semua subjek.

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Fungsi Ginjal Pasien Thalassemia Mayor yang Mendapatkan Kelasi Besi Oral

Cited by 4 publications

References 5 publications

Estimated Glomerular Filtration Rate in Pediatric Patients with β-Thalassemia Major: A Single-Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia

Estimated Glomerular Filtration Rate in Pediatric Patients with β-Thalassemia Major: A Single-Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia

Hubungan Antara Tingkat Pendidikan dan Pengetahuan Orangtua dengan Kualitas Hidup Anak Talasemia Mayor di RSUD Dr. M. Yunus Bengkulu Tahun 2017

Fungsi Ginjal Pasien Talasemia Beta Mayor yang Menggunakan Kelasi Besi Oral di Rumah Sakit Umum Zainoel Abidin Banda Aceh

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