Fungicidal activity and constituents of Ageratum conyzoides essential oil from three regions in São Paulo state, Brazil

Esper, Renata Haddad; Gonçalez, Edlayne; Felicio, Roberto Carlos; Felício, Joana D.

doi:10.1590/1808-1657000482013

Cited by 7 publications

(7 citation statements)

References 13 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, they have low molecular weight and lipophilic properties that allows them to easily penetrate cell membrane [ 28 ] causing irreversible cell wall damage and cellular organelle as well as affecting the pH homeostasis and equilibrium of inorganic ions [ 29 , 30 , 31 ]. Another study on the mode of action of E.Os on fungal growth suggested that A. conyzoides E.O was able to cross the plasma membrane of A. flavus and interact with the membrane structures of cytoplasmic organelles thus preventing the fungal growth [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Essential Oils Modulate Gene Expression and Ochratoxin A Production in Aspergillus carbonarius

Khoury

Atoui

Verheecke‐Vaessen

et al. 2016

Toxins

View full text Add to dashboard Cite

Ochratoxin A (OTA) is a mycotoxin, mainly produced on grapes by Aspergillus carbonarius, that causes massive health problems for humans. This study aims to reduce the occurrence of OTA by using the ten following essential oils (E.Os): fennel, cardamom, anise, chamomile, celery, cinnamon, thyme, taramira, oregano and rosemary at 1 µL/mL and 5 µL/mL for each E.O.As a matter of fact, their effects on the OTA production and the growth of A. carbonarius S402 cultures were evaluated, after four days at 28 °C on a Synthetic Grape Medium (SGM). Results showed that A. carbonarius growth was reduced up to 100%, when cultured with the E.Os of cinnamon, taramira, and oregano at both concentrations and the thyme at 5 µL/mL. As for the other six E.Os, their effect on A. carbonarius growth was insignificant, but highly important on the OTA production. Interestingly, the fennel E.O at 5 µL/mL reduced the OTA production up to 88.9% compared to the control, with only 13.8% of fungal growth reduction. We further investigated the effect of these E.Os on the expression levels of the genes responsible for the OTA biosynthesis (acOTApks and acOTAnrps along with the acpks gene) as well as the two regulatory genes laeA and vea, using the quantitative Reverse Transcription-Polymerase Chain Reaction (qRT-PCR) method. The results revealed that these six E.Os reduced the expression of the five studied genes, where the ackps was downregulated by 99.2% (the highest downregulation in this study) with 5 µL/mL of fennel E.O.As for the acOTApks, acOTAnrps, veA and laeA, their reduction levels ranged between 10% and 96% depending on the nature of the E.O and its concentration in the medium.

show abstract

Section: Discussionmentioning

confidence: 99%

Essential Oils Modulate Gene Expression and Ochratoxin A Production in Aspergillus carbonarius

Khoury

Atoui

Verheecke‐Vaessen

et al. 2016

Toxins

View full text Add to dashboard Cite

show abstract

“…33,54,55 whereas the bioactivity of A. conyzoides is thought to hinge on the compounds precorenes I and II. 57,57 The better inhibition and reduction of the incidence, development and spread of the leaf and stem blight by H. suaveolens over the other plant extracts in this study may have been due to higher presence of these phytochemical compound in it than in the other test plants. This finding of fungitoxic activities of the test extracts is consistent with 46 and 58 where aqueous leaf extract of S. jamaicensis and A. conyzoides inhibited F. oxysporum, P. corylophilum, A. sclerotiorum.and Botryodiplodia theobromae by 80.74-100%.…”

Section: Resultsmentioning

confidence: 70%

Antifungal Potentials of Aqueous Extracts of Selected Indigenous Flora Against Leaf and Stem Blight (Alternaria bataticola) Disease of Sweet Potato

2021

TJNPR

View full text Add to dashboard Cite

Leaf and stem blight (Alternaria bataticola) is one of the principal constraints to effective sweet potato production in many parts of the tropics. This work assessed the potentials of extracts of some indigenous plants to control the disease in vitro and under field conditions. The treatments comprised 20% aqueous extracts of Stachyterpheta jamaicensis, Cyathula prostrata, Diodia scandens, Ageratum conyzoides and Hyptis suaveolens, mancozeb and water (control). The experiment was set up in RCBD with 3 replicates. The results showed that all the extracts inhibited spore germination (65.08-78.71%) and radial growth (77.54-92.01%) of the pathogen in vitro, though these were statistically inferior (P>0.05) to 82.06 and 95.25% recorded for mancozeb respectively. The extracts of the indigenous flora also performed well in inhibiting the disease in vivo. Mancozeb gave the highest reduction of blight incidence (18.92%) and severity (1.18) on the treated crop, however the values (20.11-30.06%) and 1.24-2.79) of the indigenous flora extracts were significantly (P<0.05) superior to the control which had 81.35% and 7.47 for the respective test parameters. The high minimization of disease incidence and severity in mancozeb and extracts treated plots compared to the control may have accounted for the higher yield of root (6.07-10.65 tha -1 ) and haulm (1.37-2.51 tha -1 ) than (3.01 tha -1 and 0.87 tha -1 ) obtained for the control respectively. This study showed that smallholder farmers of sweet potato can use aqueous extracts of S. jamaicensis, C. prostrata and H. suaveolens to keep leaf and stem blight at bay and increase the productivity of the crop.

show abstract

“…As expected, similar composition showed similar activity because biological performance is correlated with the existence of secondary metabolites. This hypothesis was later confirmed by Esper et al [94] when investigation was carried out about the variation in chemical composition and antifungal effect of the essential oils obtained from three different locations (Ribeirão Pires, Ibiúna, and Campinas) of São Paulo state, Brazil. Precocene I and II were in higher proportions in the oil from Ribeirão Pires (1) and Ibiúna (2), while in the essential oil obtained from the leaves collected from Campinas (3), precocene I, (E)-caryophyllene, and α-humulene were in highest ratio as compared with traces of precocene II.…”

Section: Ageratum Conyzoides Against Fungal Genus Aspergillusmentioning

confidence: 58%

Ageratum conyzoides L. and Its Secondary Metabolites in the Management of Different Fungal Pathogens

et al. 2021

View full text Add to dashboard Cite

Ageratum conyzoides L. (Family—Asteraceae) is an annual aromatic invasive herb, mainly distributed over the tropical and subtropical regions of the world. It owns a reputed history of indigenous remedial uses, including as a wound dressing, an antimicrobial, and mouthwash as well as in treatment of dysentery, diarrhea, skin diseases, etc. In this review, the core idea is to present the antifungal potential of the selected medicinal plant and its secondary metabolites against different fungal pathogens. Additionally, toxicological studies (safety profile) conducted on the amazing plant A. conyzoides L. are discussed for the possible clinical development of this medicinal herb. Articles available from 2000 to 2020 were reviewed in detail to exhibit recent appraisals of the antifungal properties of A. conyzoides. Efforts were aimed at delivering evidences for the medicinal application of A. conyzoides by using globally recognized scientific search engines and databases so that an efficient approach for filling the lacunae in the research and development of antifungal drugs can be adopted. After analyzing the literature, it can be reported that the selected medicinal plant effectively suppressed the growth of numerous fungal species, such as Aspergillus, Alternaria, Candida, Fusarium, Phytophthora, and Pythium, owing to the presence of various secondary metabolites, particularly chromenes, terpenoids, flavonoids and coumarins. The possible mechanism of action of different secondary metabolites of the plant against fungal pathogens is also discussed briefly. However, it was found that only a few studies have been performed to demonstrate the plant’s dosage and safety profile in humans. Considered all together, A. conyzoides extract and its constituents may act as a promising biosource for the development of effective antifungal formulations for clinical use. However, in order to establish safety and efficacy, additional scientific research is required to explore chronic toxicological effects of ageratum, to determine the probability of interactions when used with different herbs, and to identify safe dosage. The particulars presented here not only bridge this gap but also furnish future research strategies for the investigators in microbiology, ethno-pharmacology, and drug discovery.

show abstract

Fungicidal activity and constituents of Ageratum conyzoides essential oil from three regions in São Paulo state, Brazil

Cited by 7 publications

References 13 publications

Essential Oils Modulate Gene Expression and Ochratoxin A Production in Aspergillus carbonarius

Essential Oils Modulate Gene Expression and Ochratoxin A Production in Aspergillus carbonarius

Antifungal Potentials of Aqueous Extracts of Selected Indigenous Flora Against Leaf and Stem Blight (Alternaria bataticola) Disease of Sweet Potato

Ageratum conyzoides L. and Its Secondary Metabolites in the Management of Different Fungal Pathogens

Contact Info

Product

Resources

About