Fungi in Cystic Fibrosis: Recent Findings and Unresolved Questions

Abstract

Patients with cystic fibrosis (CF) suffer from chronic airway infection and inflammation. Traditionally, bacteria have been regarded the main CF pathogens while fungi have emerged and more recently warranted greater attention. Fungi are increasingly found to colonize CF airways; however, their precise clinical impact continues to spark controversy. While the clinical relevance of allergic bronchopulmonary aspergillosis (ABPA) in CF has been established, the roles of non-ABPA Aspergillus fumigatus, Candida albicans, and other more rare emerging fungi remain poorly understood. Here, we summarize and discuss recent findings in this field and refer toward unresolved questions.

Characterizing the Human Mycobiota: A Comparison of Small Subunit rRNA, ITS1, ITS2, and Large Subunit rRNA Genomic Targets

“…Fungal species candidates were selected based on taxa previously identified in a broad range of published studies, including of the lung ( Agbetile et al, 2012 ; Charlson et al, 2012 ; Delhaes et al, 2012 ; Huffnagle and Noverr, 2013 ; Liu et al, 2013 ; van Woerden et al, 2013 ; Bittinger et al, 2014 ; Chotirmall and McElvaney, 2014 ; Pashley, 2014 ; Pourfathollah et al, 2014 ; Willger et al, 2014 ; Eickmeier et al, 2015 ; Nguyen et al, 2015 ; Sharpe et al, 2015 ), sinonasal cavity ( Aurora et al, 2013 ; Cleland et al, 2014 ; Jung et al, 2015 ; Comacle et al, 2016 ; Gelber et al, 2016 ; Zhao et al, 2017 ), oral cavity ( Ghannoum et al, 2010 ; Huffnagle and Noverr, 2013 ; Dupuy et al, 2014 ; Underhill and Iliev, 2014 ; Vesty et al, 2017 ), gastrointestinal tract ( Huffnagle and Noverr, 2013 ; Kim et al, 2014 ; Li et al, 2014 ; Underhill and Iliev, 2014 ; Wang Z.K. et al, 2014 ; Gerard et al, 2015 ; Tang et al, 2015 ; Hoarau et al, 2016 ; Liguori et al, 2016 ; Strati et al, 2016 ; Hallen-Adams and Suhr, 2017 ; Nash et al, 2017 ), vagina ( Underhill and Iliev, 2014 ), and skin ( Zhang et al, 2011 ; Park et al, 2012 ; Findley et al, 2013 ; Huffnagle and Noverr, 2013 ; Underhill and Iliev, 2014 ).…”

Modern Approaches in Management of Children with Cystic fibrosis

“…В настоящее время нет убедительных данных о негативном влиянии колонизации Aspergillus spp. дыхатель-ных путей на функцию дыхания пациентов с МВ [12][13][14]. Колонизация дыхательных путей пациентов с МВ грибами Aspergillus spp.…”