Fungi Impacting Human Health

Kunta, Niharika; Kunta, Madhurababu

doi:10.1007/978-981-19-9103-5_22

Cited by 1 publication

(2 citation statements)

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“…Therefore, the permeation profile of each dosage form from any drug may need to be assessed to help the picking up and select the best vehicle which may give the desired therapeutic effect form the different dosage forms in the market. Beside this, it could also help when designing transdermal Menthol was extensively studied and used to enhance the penetration through the skin of many drugs because of its many advantages such as low tendency to irritate the skin and a low concentration of menthol is enough to give a significant enhancement [13]. In addition, menthol used to increase the penetration of many drugs with a different water solubility [24].…”

Section: Permeability Studymentioning

confidence: 99%

“…However, these chemicals may cause many adverse effects hence restrict their use until safety profile established [10]. Presently, many studies focused on naturally occurring chemicals such as terpenes which presents good enhancing effect including menthol on many drugs such as indomethacin, nifedipine propranolol tetracaine and diclofenac sodium [11][12][13][14][15] Thus the objective of this study was to formulate and evaluate diclofenac sodium (1% w\w) in three semi-solid dosage forms , gel, cream, and emulgel;…”

Section: Introductionmentioning

confidence: 99%

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Formulation and Evaluation of Diclofenac Sodium in Different Transdermal Drug Delivery Systems

Elhassan¹,

Omer²,

Gadien³

et al. 2022

OJPS

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Diclofenac sodium is found in different topical dosage forms which varied in their percuetanus absorption and hence in their therapeutic effect. In this study, three different formulations gel, emulgel and cream, containing 1% diclofenac sodium were developed in order to compare their permeation through rabbite skin using franz diffusion cells. They were subjected to various evalution tests such as physical appearance and rheological behavior. Menthol was added to the prepared formulations in a quanitity of about 1% , as permeation enhancer, and the enhancement in permeability was assessed. Carbopol gel, aqueous cream and emulgel showed acceptable results concerning color, spreadabilty, and homogenisity. The results showed that the cumulative amount of diclofenac sodium that permeated from the prepared formulations in this order gel > cream > emulgel. The addition of menthol to the formulation resulted in an increase in the amount of drug permeated. The study emphasized that optimization of the type of transdermal dosage forms and the addition of a peneteration enhancer can be resulted in an acceptable permeated amount of diclofenac sodium through the skin.

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Section: Permeability Studymentioning

confidence: 99%