1981
DOI: 10.1016/0002-9343(81)90162-5
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Fungemia in the immunocompromised host

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Cited by 436 publications
(53 citation statements)
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“…In contrast, anti-mannan antibody titers in the sera of immunocompromised patients that were only colonized with C. albicans were significantly lower and tended to decrease. The fact that anti-mannan antibody levels increased so quickly in patients with invasive disease is compatible with a secondary immune response to an antigen against which antibodies are already present in normal human sera (15). The follow-up of anti-mannan antibody titers for detection of Candida infection was recently confirmed in a study of children with malignant disease and invasive candidiasis (17).…”
Section: Discussionmentioning
confidence: 90%
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“…In contrast, anti-mannan antibody titers in the sera of immunocompromised patients that were only colonized with C. albicans were significantly lower and tended to decrease. The fact that anti-mannan antibody levels increased so quickly in patients with invasive disease is compatible with a secondary immune response to an antigen against which antibodies are already present in normal human sera (15). The follow-up of anti-mannan antibody titers for detection of Candida infection was recently confirmed in a study of children with malignant disease and invasive candidiasis (17).…”
Section: Discussionmentioning
confidence: 90%
“…Antibodies directed against cell wall mannan were determined by hemagglutination (HA) (15). The mannan-containing antigen was prepared from C. albicans CBS 5982 by means of natamycin degradation as described earlier (7), and coupled to sheep erythrocytes with concanavalin A.…”
Section: Methodsmentioning
confidence: 99%
“…Infection is one of the main causes of death in leukemic patients. The microorganisms responsible for these infections are often intestinal bacteria or Candida (9,14). Many studies (1, 2, 4, 5, 8, 10) have been done on infection during antileukemic therapy.…”
Section: Discussionmentioning
confidence: 99%
“…andida albicans is responsible for the majority of severe systemic fungal diseases occurring in immunocompromised patients (1,2). High mortality (ϳ60%) is observed among these patients, despite treatment with antifungal drugs (3,4).…”
mentioning
confidence: 99%