Fungemia in the immunocompromised host

Meunier-Carpentier, F.; Kiehn, Timothy E.; Armstrong, Donald

doi:10.1016/0002-9343(81)90162-5

Cited by 436 publications

(53 citation statements)

References 20 publications

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“…In contrast, anti-mannan antibody titers in the sera of immunocompromised patients that were only colonized with C. albicans were significantly lower and tended to decrease. The fact that anti-mannan antibody levels increased so quickly in patients with invasive disease is compatible with a secondary immune response to an antigen against which antibodies are already present in normal human sera (15). The follow-up of anti-mannan antibody titers for detection of Candida infection was recently confirmed in a study of children with malignant disease and invasive candidiasis (17).…”

Section: Discussionmentioning

confidence: 90%

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Kinetics of Anti‐Mannan Antibodies Useful in Confirming Invasive Candidiasis in Immunocompromised Patients

Deventer

Goessens

Zeijl

et al. 1996

Microbiology and Immunology

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Section: Discussionmentioning

confidence: 90%

“…Antibodies directed against cell wall mannan were determined by hemagglutination (HA) (15). The mannan-containing antigen was prepared from C. albicans CBS 5982 by means of natamycin degradation as described earlier (7), and coupled to sheep erythrocytes with concanavalin A.…”

Section: Methodsmentioning

confidence: 99%

Kinetics of Anti‐Mannan Antibodies Useful in Confirming Invasive Candidiasis in Immunocompromised Patients

Deventer

Goessens

Zeijl

et al. 1996

Microbiology and Immunology

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“…Infection is one of the main causes of death in leukemic patients. The microorganisms responsible for these infections are often intestinal bacteria or Candida (9,14). Many studies (1, 2, 4, 5, 8, 10) have been done on infection during antileukemic therapy.…”

Section: Discussionmentioning

confidence: 99%

Intestinal Candida Overgrowth and Candida Infection in Patients with Leukemia: Effect of Bifidobacterium Administration

Tomoda¹,

Nakano²,

Kageyama

1988

Bifidobacteria Microflora

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The number of intestinal Candida was correlated with the incidence of Candida infection. The number of intestinal Candida was higher in patients receiving antileukemic chemotherapy than in normal subjects. Respiratory and urinary infections were increased in patients with more than 105 Candida/g feces. Bifidobacterium administered orally to patients with more than 105 Candida/g feces, reduced the incidence of infection if the intestinal Candida population fell to less than 104/g feces.

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“…andida albicans is responsible for the majority of severe systemic fungal diseases occurring in immunocompromised patients (1,2). High mortality (ϳ60%) is observed among these patients, despite treatment with antifungal drugs (3,4).…”

mentioning

confidence: 99%

Neutrophil FcγRI as Target for Immunotherapy of Invasive Candidiasis

Spriel¹,

Herik-Oudijk²,

Winkel

2001

The Journal of Immunology

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Invasive candidiasis represents a life-threatening disease for immunocompromised patients. This study focused on new immunotherapeutic approaches for systemic Candida albicans infections in a human FcγRI-transgenic mouse model. FcγRI (CD64) is a potent immunoactivating receptor on phagocytic and dendritic cells. In vivo targeting of C. albicans toward neutrophil-FcγRI by bispecific Abs and G-CSF effectively protected FcγRI-transgenic mice from lethal candidiasis. Nontransgenic mice were not protected, and treatment with bispecific Ab or G-CSF alone did not reduce mortality. Furthermore, infected FcγRI-transgenic mice developed high titers of anti-C. albicans IgG, and survival was extended on secondary infection without further treatment. These findings document the capacity of FcγRI to initiate potent anti-C. albicans immunity and support the development of FcγRI-directed immunotherapy of invasive fungal disease.

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Fungemia in the immunocompromised host

Cited by 436 publications

References 20 publications

Kinetics of Anti‐Mannan Antibodies Useful in Confirming Invasive Candidiasis in Immunocompromised Patients

Kinetics of Anti‐Mannan Antibodies Useful in Confirming Invasive Candidiasis in Immunocompromised Patients

Intestinal Candida Overgrowth and Candida Infection in Patients with Leukemia: Effect of Bifidobacterium Administration

Neutrophil FcγRI as Target for Immunotherapy of Invasive Candidiasis

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