Fungal spondylitis: A case ofTorulopsis glabrataandCandida tropicalisinfection

Bruns, J.; Hemker, Torsten; G, Dahmen

doi:10.3109/17453678609014795

Cited by 25 publications

(9 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are a few reported cases of C. glabrata arthritis (12,26) and C. glabrata-infected joint endoprostheses (27)(28)(29)(30)(31). Other musculoskeletal infections involving localized C. glabrata include osteomyelitis, spondylitis, and spondylodiscitis (32)(33)(34)(35)(36)(37)(38)(39)(40).…”

Section: Discussionmentioning

confidence: 99%

Candida glabrata Olecranon Bursitis Treated With Bursectomy and Intravenous Caspofungin

Skedros¹,

Keenan²,

Trachtenberg³

2013

J Surg Orthop Adv

View full text Add to dashboard Cite

Orthopedic surgeons are becoming more involved in the care of patients with septic arthritis and bursitis caused by yeast species. This case report involves a middle-aged immunocompromised female who developed a Candida glabrata septic olecranon bursitis that developed after she received a corticosteroid injection in the olecranon bursa for presumed aseptic bursitis. Candida (Torulopsis) glabrata is the second most frequently isolated Candida species from the bloodstream in the United States. Increased use of fluconazole and other azole antifungal agents as a prophylactic treatment for recurrent Candida albicans infections in immunocompromised individuals is one reason why there appears to be increased resistance of C. glabrata and other nonalbicans Candida (NAC) species to fluconazole. In this patient, this infection was treated with surgery (bursectomy) and intravenous caspofungin, an echinocandin. This rare infectious etiology coupled with this intravenous antifungal treatment makes this case novel among cases of olecranon bursitis caused by yeasts.

show abstract

Section: Discussionmentioning

confidence: 99%

Candida glabrata Olecranon Bursitis Treated With Bursectomy and Intravenous Caspofungin

Skedros¹,

Keenan²,

Trachtenberg³

2013

J Surg Orthop Adv

View full text Add to dashboard Cite

show abstract

“…Candida albicans is the most common species reported in English language literature. There have also been reports of infections due to Candida tropicalis, Candida lusitaniae, Candida paratropicalis, Candida parapsilosis, Candida pseudotropicalis, Candida guilliermondii and Torulopsis glabrata [22, 23].…”

Section: Discussionmentioning

confidence: 99%

Case Report. Successful treatment of two cases of post‐surgical sternal osteomyelitis, due to Candida krusei and Candida albicans, respectively, with high doses of triazoles (fluconazole, itraconazole)

Petrikkos

Skiada

Sabatakou

et al. 2001

Mycoses

View full text Add to dashboard Cite

Two female patients, aged 75 and 59 years, respectively, with candidal sternal osteomyelitis were successfully treated by the administration of triazoles. Both had developed post-operative wound infection after sternotomy for coronary artery by-pass grafting. Sternal osteomyelitis was confirmed by bone scans with technetium 99Tc and gallium 67Ga. The cultures, from the pus draining at the site of the sternotomy scar, grew Candida krusei in the first case. The fistula closed after a 9-week course of itraconazole therapy (800 mg daily, followed by 600 mg daily) and the patient completed a 6-month period of therapy. The second patient had underlying diabetes mellitus. Post-operatively she developed two fistulae draining pus on the sternum. The pus cultures grew C. albicans. Initial treatment with oral fluconazole (400 mg daily) failed. Subsequent treatment with liposomal amphotericin B also failed. A dramatic improvement was noted when the patient received high doses of fluconazole (800 mg daily). The fistulae gradually closed after 1 month. Oral fluconazole was continued for 6 months. The cure was confirmed by bone scans. Three years later, both patients remained well.

show abstract

“…The main co-morbid conditions identified in both the literature review and our cohort were diabetes mellitus, malignancies and prior surgeries involving upper airways or the esophagus. These findings suggest that patients presenting with indolent, persistent, back pain and who have received radiation or chemotherapy for upper airway or esophageal malignancies, should be evaluated for the possibility of CVO [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28].…”

Section: Figure 1 Outcomes Of Candida Vertebral Osteomyelitis Patienmentioning

confidence: 98%

Vertebral Osteomyelitis Due to Candida Species: A Cohort Study and Review of the Literature

Ramos¹,

Huddleston²,

Patel³

et al. 2013

OJO

View full text Add to dashboard Cite

Objective: To describe the demographics and outcome of patients with candidal vertebral osteomyelitis (CVO). CVO is a rare and frequently misdiagnosed condition. It may lead to destruction of the vertebral bodies, spinal cord compression and neurological deficits. Methods: The medical records of all patients diagnosed with CVO at our institution between 01/01/1990-12/31/2009 were reviewed. The cumulative probability of treatment success was assessed by the Kaplan-Meier survival method. Patients were followed until death, failure, or loss of follow-up. Results: Nine patients developed CVO during the 20 year study period. The cervical spine was involved in 5 cases. Seven patients presented with mechanical-type pain, while 2 patients had an elevated temperature at diagnosis. A contiguous infection between the upper airways and the cervical spine was present in 4 patients. One patient presented with concomitant candidemia. Candida albicans, Candida parapsilosis, and Candida glabrata were cultured in 3 of 9 cases respectively. Eight of 9 were treated with azole-based therapy. Patients were followed for an average of 20 months (range 1-75 months). The cumulative incidence of success was 66% ± 19% at 1 year and 55% ± 20% at 2 years of follow-up. Conclusions: CVO presents insidiously and is associated with a long duration of symptoms. It most frequently affects the cervical spine and is associated with a poor outcome.

show abstract

Fungal spondylitis: A case ofTorulopsis glabrataandCandida tropicalisinfection

Cited by 25 publications

References 8 publications

Candida glabrata Olecranon Bursitis Treated With Bursectomy and Intravenous Caspofungin

Candida glabrata Olecranon Bursitis Treated With Bursectomy and Intravenous Caspofungin

Case Report. Successful treatment of two cases of post‐surgical sternal osteomyelitis, due to Candida krusei and Candida albicans, respectively, with high doses of triazoles (fluconazole, itraconazole)

Vertebral Osteomyelitis Due to <i>Candida</i> Species: A Cohort Study and Review of the Literature

Contact Info

Product

Resources

About

Fungal spondylitis: A case ofTorulopsis glabrataandCandida tropicalisinfection

Cited by 25 publications

References 8 publications

Candida glabrata Olecranon Bursitis Treated With Bursectomy and Intravenous Caspofungin

Candida glabrata Olecranon Bursitis Treated With Bursectomy and Intravenous Caspofungin

Case Report. Successful treatment of two cases of post‐surgical sternal osteomyelitis, due to Candida krusei and Candida albicans, respectively, with high doses of triazoles (fluconazole, itraconazole)

Vertebral Osteomyelitis Due to &lt;i&gt;Candida&lt;/i&gt; Species: A Cohort Study and Review of the Literature

Contact Info

Product

Resources

About

Vertebral Osteomyelitis Due to <i>Candida</i> Species: A Cohort Study and Review of the Literature