Fungal Splenic Abscess

Johnson, Judith D.

doi:10.1001/archinte.1984.04400010099018

Cited by 39 publications

(6 citation statements)

References 36 publications

(2 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chronic disseminated candidiasis is being recognized with increasing frequency [43][44][45][46][47][48][49][50][51][52][53]. Typically, the patient has a hematologic malignancy and acquires the infection after myelosuppressive chemotherapy.…”

Section: The Spectrum Of Disseminated Candidiasis In the Neutropenic mentioning

confidence: 99%

“…This infection has been reported with increasing frequency, is responsible for significant delays in the therapy for the underlying malignancy, is highly likely to be fatal if therapy is not administered, is difficult to diagnose and treat, and therefore frequently requires long-term combination chemotherapy with amphotericin B plus 5-fluorocytosine. Only 50% of patients respond to therapy with amphotericin B with or without 5-fluorocytosine, and a significant number of patients die of infection despite antifungal therapy [43][44][45][46][47][48][49][50][51][52][53]. Although the previously used term "hepatosplenic candidiasis" suggests that the infection is limited to the liver and spleen, the clinicopathological features of this syndrome clearly indicate that the infection involves multiple organs.…”

Section: The Spectrum Of Disseminated Candidiasis In the Neutropenic mentioning

confidence: 99%

See 1 more Smart Citation

Opportunistic Mycoses in the Immunocompromised Host: Experience at a Cancer Center and Review

Anaissie

1992

Clinical Infectious Diseases

341

172

View full text Add to dashboard Cite

The field of opportunistic mycoses in the patient with cancer is rapidly changing. Not only are fungal infections increasing in frequency in this patient population, but these infections are occurring earlier during the course of cytotoxic chemotherapy, and newer fungi are increasingly recognized as potentially lethal pathogens. Candidiasis remains the most commonly encountered infection. The spectrum of disease includes candidemia and acute and chronic disseminated candidiasis. Pulmonary aspergillosis and disseminated aspergillosis are common and remain relatively resistant to therapy. Disseminated fusariosis and trichosporosis are almost always fatal in the setting of persistent profound neutropenia. Therapy for these mycoses relies on the use of amphotericin B and 5-fluorocytosine. Newer antifungal agents, such as fluconazole and itraconazole, appear to exhibit good activity against a variety of fungi. Newer approaches need to be tested for the treatment of the more-resistant mycoses and may include the use of maximally tolerated doses of antifungal agents, colony-stimulating factors, and combination therapy.

show abstract

Section: The Spectrum Of Disseminated Candidiasis In the Neutropenic mentioning

confidence: 99%

Section: The Spectrum Of Disseminated Candidiasis In the Neutropenic mentioning

confidence: 99%

Opportunistic Mycoses in the Immunocompromised Host: Experience at a Cancer Center and Review

Anaissie

1992

Clinical Infectious Diseases

341

172

View full text Add to dashboard Cite

show abstract

“…The findings are indistinguishable from those of other fungal lesions. 24 Percutaneous image-guided aspiration may be performed to confirm the diagnosis if necessary.…”

Section: Fungal Infectionsmentioning

confidence: 99%

Imaging in Bone Marrow Transplantation

Clark

1999

Cancer Control

View full text Add to dashboard Cite

This regular feature will enhance your knowledge of imaging technology in oncologic diagnosis, treatment, and evaluation. The Bone Marrow Transplantation Procedure Bone marrow transplantation (BMT) is a technique used in the treatment of leukemia, lymphoma, aplastic anemia, multiple myeloma, immune deficiency disorders, and certain solid tumors such as breast and ovarian carcinoma. It is a salvage technique that permits high-dose, myelosuppressive chemotherapy to be given, achieving greater response rates to therapy. After giving high-dose therapy, treating the disease, and ablating the marrow, BMT salvage is accomplished by infusing the patient with new marrow. New marrow obtained from HLA-matched relatives or unrelated donors is an allogeneic transplant; marrow from an identical twin is a syngeneic transplant. If the marrow is successfully incorporated into the patient, the transplant is termed engrafted. If the genetic match of an allogeneic transplant is less than ideal, the infused marrow may produce an immune response against the tissue of the host, the so-called graft-vs-host reaction. Alternatively, the patient's immune system may destroy the new marrow, a process termed graft rejection. If the disease does not involve the marrow, as in lymphoma or solid tumors, or if the disease involving the marrow is in remission, patients may donate their own marrow, providing autologous transplants. In such cases, marrow is extracted and stored prior to chemotherapy. Autologous transplants are more common than allogeneic transplants.

show abstract

“…Splenic candidiasis may be the predominant clinically overt component of hepatosplenic candidiasis (44,48). Left subphrenic abscess due to extension of fungi beyond the splenic capsule may be the presenting manifestation.…”

Section: Hepatosplenic Candidiasismentioning

confidence: 99%

“…Left subphrenic abscess due to extension of fungi beyond the splenic capsule may be the presenting manifestation. A recent review of splenic candidiasis (48) found that 12 of 16 patients who underwent laparotomy and splenectomy for splenic candidiasis received post operative i. v. amphotericin B, and all but one patient survived. The one death in this group was a patient with disseminated candidiasis whose amphotericin B was discontinued prematurely.…”

Section: Hepatosplenic Candidiasismentioning

confidence: 99%