Fungal pulmonary abscess in an adult secondary to hyperimmunoglobulin E (Job's) syndrome

Ra, Hall; Ke, Salhany; Lebel, Ehud; Je, Bavaria; Lr, Kaiser

doi:10.1016/0003-4975(94)00730-6

Cited by 21 publications

(6 citation statements)

References 13 publications

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“…Aspergillus species may also affect HIES patients, usually by colonizing pre-existing pneumatocoeles and forming aspergillomas. Occasionally, however, local invasion of the lung parenchyma may occur, and this can rarely be followed by dissemination to the central nervous system and formation of mycotic aneurysms [98][99][100][101]. In a series of 64 AD HIES patients, 28.1% developed mould infections caused by Aspergillus (n = 16) or Scedosporium (n = 2) species.…”

Section: Other Congenital Immunodeficienciesmentioning

confidence: 95%

Invasive fungal infections in congenital immunodeficiencies

Antachopoulos

2010

Clinical Microbiology and Infection

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Both acquired and congenital immunodeficiencies may be associated with increased susceptibility to invasive fungal infections (IFIs), depending on the type of immune deficit. IFIs frequently occur in patients with phagocytic and cellular immune defects, but are rarely observed in those with humoral or complement deficits. Among congenital immune disorders, chronic granulomatous disease and hyper-IgE syndrome are most frequently associated with IFIs; variable susceptibility to fungal pathogens is also seen in patients with severe combined immunodeficiency, X-linked hyper-IgM syndrome, Wiskott-Aldrich syndrome, DiGeorge syndrome, common variable immunodeficiency, defects in the interferon-γ-interleukin-12 axis, and myeloperoxidase deficiency. Aspergillus, Candida, Cryptococcus, Histoplasma and other fungal genera are variably implicated in causing invasive infections in these patients. Prompt diagnosis of IFIs in this patient population requires a high degree of suspicion, together with a knowledge of their clinical presentation and the limitations of diagnostic modalities. Apart from administration of appropriate antifungal agents, successful management often requires the addition of surgical intervention. Adjunctive immunotherapy may be considered, although this has not been systematically studied. Prophylactic interferon-γ and itraconazole administration have been shown to reduce the risk of IFIs in patients with chronic granulomatous disease; however, the possibility of infections with azole-resistant organisms following long-term itraconazole prophylaxis should not be overlooked.

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Section: Other Congenital Immunodeficienciesmentioning

confidence: 95%

Invasive fungal infections in congenital immunodeficiencies

Antachopoulos

2010

Clinical Microbiology and Infection

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“…The usual presentation includes non-productive cough or hemoptysis. Most cases in the literature have been managed with a combination of antifungal therapy and surgical resection [4,51,57,58,141,166,183]. Another filamentous fungus, S. prolificans, was isolated from lung and brain lesions of a patient with hyperIgE syndrome in a recent autopsy series [51].…”

Section: Hyper-ige Syndromementioning

confidence: 98%

Fungal infections in primary immunodeficiencies

2007

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Patients with phagocytic, cellular, combined and other primary immunodeficiencies exhibit immune deficits that confer increased susceptibility to fungal infections. A number of yeasts and moulds, most commonly Candida and Aspergillus but also Cryptococcus, Histoplasma, Paecilomyces, Scedosporium, Trichosporon, Penicillium and other, rarely isolated, fungal organisms, have been variably implicated in causing disease in patients with chronic granulomatous disease, severe combined immunodeficiency, chronic mucocutaneous candidiasis, hyper-IgE syndrome, myeloperoxidase deficiency, leukocyte adhesion deficiency, defects in the interferon-gamma/interleukin-12 axis, DiGeorge syndrome, X-linked hyper-IgM syndrome, Wiskott-Aldrich syndrome and common variable immunodeficiency. Differences in the spectrum of fungal pathogens as well as in the incidence and clinical presentation of the infections may be observed among patients, depending upon different immune disorders. Fungal infections in these individuals may occasionally be the presenting clinical manifestation of a primary immunodeficiency and can cause significant morbidity and potentially fatal outcome if misdiagnosed or mistreated. A high degree of suspicion is needed and establishment of diagnosis should actively be pursued using appropriate imaging, mycological and histological studies. A number of antifungal agents introduced over the last fifteen years, such as the lipid formulations of amphotericin B, the second-generation triazoles, and the echinocandins, increase the options for medical management of these infections. Surgery may also be needed in some cases, while the role of adjunctive immunotherapy has not been systematically evaluated. The low incidence of primary immunodeficiencies in the general population complicates single-center prospective or retrospective clinical studies aiming to address diagnostic or therapeutic issues pertaining to fungal infections in these patients.

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“…Fungal abscesses were reported in various organs as the liver, brain, lung and spleen. 6 , 7 , 8 , 9 To the best of our knowledge, there are no reports in the literature that relate development of a psoas abscess to fungal infection. The patient in this study had bilateral primary vesico-ureteral reflux that facilitated direct spread of the fungal infection to the ureters.…”

Section: Discussionmentioning

confidence: 99%

Psoas Abscess Secondary to Urinary Tract Fungal Infection

Aldamanhori

Barakat

Al-Madi

et al. 2015

Urology Case Reports

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Psoas abscess is a rare condition where infection spreads from a nearby or distant septic focus to the psoas sheath. The causative bacterial organisms at distal sites reach the psoas via lymphatic or hematogenous spread, whereas infection from nearby sites that include the urinary system reaches the psoas directly. There are few reports that account for bacterial infection after endourological procedures as the cause of direct spread of infection to the psoas muscle.2 We report a case of psoas abscess caused by fungal infection that spread from an injured left ureter to the psoas sheath.

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Fungal pulmonary abscess in an adult secondary to hyperimmunoglobulin E (Job's) syndrome

Cited by 21 publications

References 13 publications

Invasive fungal infections in congenital immunodeficiencies

Invasive fungal infections in congenital immunodeficiencies

Fungal infections in primary immunodeficiencies

Psoas Abscess Secondary to Urinary Tract Fungal Infection

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