Fungal pathogenesis: Past, present and future

Taylor, Claire Maree; Gurr, Sarah J.

doi:10.1016/j.fbr.2014.02.003

Cited by 9 publications

(4 citation statements)

References 29 publications

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“…has been the most common dermatophyte isolated from glabrous skin and nail dermatophytic infections worldwide (Borman et al, 2007;Taylor and Gurr, 2014). This phenomenon is also likely due to urbanization, the use of sports and fitness facilities, the growing prevalence of obesity, and an aging population (Ilkit and Durdu, 2015).…”

Section: Discussionmentioning

confidence: 99%

Xanthomegnin detection does not discriminate between Trichophyton rubrum and T. mentagrophytes complexes

Kandemir

İlkit

Çürük

2015

Journal of Microbiological Methods

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Section: Discussionmentioning

confidence: 99%

Xanthomegnin detection does not discriminate between Trichophyton rubrum and T. mentagrophytes complexes

Kandemir

İlkit

Çürük

2015

Journal of Microbiological Methods

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“…The entire process includes host recognition, mechanical damage, nutrient competition, metabolism disturbance, secretion of toxins and damage of host tissue structure. These multifactor interactions ultimately lead to host death and form the matured O. sinensis (Taylor and Gurr 2014). Theoretically, the invasion can directly cause insect infection without depending on feeding activities of host.…”

Section: Discussionmentioning

confidence: 99%

Genome sequencing and analysis of fungus Hirsutella sinensis isolated from Ophiocordyceps sinensis

Jin

Zhang

et al. 2020

AMB Expr

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Ophiocordyceps sinensis has been used as a traditional medicine or healthy food in China for thousands of years. Hirsutella sinensis was reported as the only correct anamorph of O. sinensis. It is reported that the laboratory-grown H. sinensis mycelium has similar clinical efficacy and less associated toxicity compared to the wild O. sinensis. The research of the H. sinensis is becoming more and more important and urgent. To gain deeper insight into the biological and pharmacological mechanisms, we sequenced the genome of H. sinensis. The genome of H. sinensis (102.72 Mb) was obtained for the first time, with > 99% coverage. 10,200 protein-encoding genes were predicted based on the genome sequence. A detailed secondary metabolism analysis and structure verification of the main ingredients were performed, and the biosynthesis pathways of seven ingredients (mannitol, cordycepin, purine nucleotides, pyrimidine nucleotides, unsaturated fatty acid, cordyceps polysaccharide and sphingolipid) were predicted and drawn. Furthermore, infection process and mechanism of H. sinensis were studied and elaborated in this article. The enzymes involved in the infection mechanism were also predicted, cloned and expressed to verify the mechanism. The genes and proteins were predicted and annotated based on the genome sequence. The pathways of several active components in H. sinensis were predicted and key enzymes were confirmed. The work presented here would improve the understanding of the genetic basis of this organism, and contribute to further research, production and application of H. sinensis.

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“…For example, the ability to grow at 37 °C (a trait that is shared by all human pathogens) can be readily explained by the propensity of Cryptococcus cells to be found in high‐temperature environments. However, of the estimated 1.5 million fungal microbial taxa (Hawksworth, ) (a number that may well be lower than the true number), a small minority cause disease in animals, and even fewer [~300 (Taylor and Gurr, )] cause disease in humans. Furthermore, when one considers the myriad selection environments required for a Cryptococcus cell to traverse the human body from lungs to brain (Figure ), it seems unlikely that the abiotic environment could select for these abilities.…”

Section: Abiotic Selection In the Environment: Backdoor To Human Virumentioning

confidence: 99%

It's not all about us: evolution and maintenance ofCryptococcusvirulence requires selection outside the human host

Gerstein

Nielsen

2017

Yeast

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Cryptococcus is predominantly an AIDS-related pathogen that causes significant morbidity and mortality in immunocompromised patients. Research studies have historically focused on understanding how the organism causes human disease through the use of in vivo and in vitro model systems to identify virulence factors. Cryptococcus is not an obligate pathogen, however, as human-human transmission is either absent or rare. Selection in the environment must thus be invoked to shape the evolution of this taxa, and directly influences genotypic and trait diversity. Importantly, the evolution and maintenance of pathogenicity must also stem directly from environmental selection. To that end, here we examine abiotic and biotic stresses in the environment, and discuss how they could shape the factors that are commonly identified as important virulence traits. We identify a number of important unanswered questions about Cryptococcus diversity and evolution that are critical for understanding this deadly pathogen, and discuss how implementation of modern sampling and genomic tools could be utilized to answer these questions. Copyright © 2016 John Wiley & Sons, Ltd.

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Fungal pathogenesis: Past, present and future

Cited by 9 publications

References 29 publications

Xanthomegnin detection does not discriminate between Trichophyton rubrum and T. mentagrophytes complexes

Xanthomegnin detection does not discriminate between Trichophyton rubrum and T. mentagrophytes complexes

Genome sequencing and analysis of fungus Hirsutella sinensis isolated from Ophiocordyceps sinensis

It's not all about us: evolution and maintenance ofCryptococcusvirulence requires selection outside the human host

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