Fungal mycelia as the source of chitin and polysaccharides and their applications as skin substitutes

Su, Ching‐Hua; Sun, Chi-Shu; Juan, Shan-Wei; Hu, Chung‐Hong; Ke, Wen-Ting; Sheu, Ming Thau

doi:10.1016/s0142-9612(97)00048-3

Cited by 114 publications

(75 citation statements)

References 14 publications

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“…CF 10 shown maximum folding endurance among drug loaded films, which indicated that it may have maximum flexibility among drug loaded films as shown in table 1. The water absorption capacity of composite films was significantly increased with increase in gelatin concentration, which may be due to hydrophilic and swelling properties of gelatin [14,22] as shown in table 1. A composite film F6 has shown maximum water absorption capacity among all the prepared composite films.…”

Section: Resultsmentioning

confidence: 99%

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Preparation and evaluation of ciprofloxacin loaded chitosan-gelatin composite films for wound healing activity.

Tvl¹,

Vidyavathi²,

Kavitha³

et al. 2010

Int j Drug delivery

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Back ground: Natural polymers are used as lead compounds for design of drugs in treatment of different ailments. Chitosan and gelatin have proven wound healing properties individually. As both have wound healing property, the combination of these two polymers and incorporation of drugs into the composite films may show improvement in wound healing activity. Thus, the composite films and drug loaded films were evaluated for various in vitro evaluation tests to ascertain the applicability of prepared combination for wound healing activity. The composite films were prepared with increase in gelatin concentration and the drug loaded films were prepared with increased concentrations of drug in optimized composite film. These films were evaluated for thickness, folding endurance, water absorption capacity, antibacterial activity, tensile strength, drug load, content uniformity, in vitro drug release by diffusion studies and in vivo wound healing studies by excision wound model using albino rats. Results: The drug loaded films shown significant difference in folding endurance, water absorption capacity, antibacterial activity when compared to optimized blank composite film. There was no significant difference in thickness and tensile strength of drug loaded films when compared to blank composite films. Percentage of wound contraction was more for wounds treated with ciprofloxacin loaded composite film than blank composite film. Conclusions:With the above results, it was concluded that ciprofloxacin loaded chitosan-gelatin composite films had shown more wound healing property than chitosan-gelatin blank composite film and blank chitosan film without interfering in strength of film.

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Section: Resultsmentioning

confidence: 99%

“…It is used in drug delivery, cell delivery systems, orthopaedics, wound healing [6], ophthalmology, and bone healing [12]. It enhances the function of polymorphonuclear cells, macrophages [13] and fibroblastic proliferation and migration [14]. It exhibits antimicrobial activity against bacteria [15], fungi, and yeast.…”

Section: Introductionmentioning

confidence: 99%

Preparation and evaluation of ciprofloxacin loaded chitosan-gelatin composite films for wound healing activity.

Tvl¹,

Vidyavathi²,

Kavitha³

et al. 2010

Int j Drug delivery

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“…In parallel, Su et al (1997) was followed to prepare the contrast sample "mimic sacchachitin Su et al (MSC)".…”

Section: Fractionation Of Polysaccharides and Preparation Of Sacchachmentioning

confidence: 99%

“…The term "sacchachitin" was first used by Su et al (1997) for description of special glucosamine derivative isloated from G. tsuga. This Su's sacchachitin is a copolymer made from β-1,3-glucan (approximately 60%) and N-acetylglucosamine (approximately 40%), having a filamental structure.…”

Section: Introductionmentioning

confidence: 99%

Sacchachitin, a novel chitin-polysaccharide conjugate macromolecule present inGanoderma lucidum: Purification, composition, and properties

Chuang¹,

Wang

Chang

et al. 2012

Pharmaceutical Biology

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“…Chitosan has been examined to be used in a wide variety of biomedical applications, such as drug delivery carriers, surgical thread, bone-healing materials, especially wound dressing (Biagini et al 1991, Berthod et al 1993, Abhay 1998, Su et al 1997. Chitosan is a semi-crystal polymer and its membrane has lower gas permeability in original state (Muzzarelli et al 1974).…”

mentioning

confidence: 99%

Preparation and characterization of fibrin-chitosan composite and its in vivo studies

M¹

2012

iosrphr

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Abstract--Biomaterials are used in regenerative medicine, implantable materials, controlled release carriers or scaffolds for tissue engineering. Biological dressings like fibrin glue, gelatin sheets, chitosan films, collagen is popular for quicker wound healing. These polymers when used in combination such as fibringelatin, fibrin-chitosan has shown better results, than when used alone. Thus, the present research work is concentrated on the preparation and evaluation of composite films made with chitosan-fibrin to ascertain the applicability of the prepared combination for wound management. Temporary biological wound dressings were prepared, in film form, using physiologically clotted fibrin and chitosan (FC) employing PVP as porogen. The films were characterized for their percentage equilibrium water content (% EWC), water vapour transmission rate (WVTR), bacterial penetration, surface morphology and in vivo biodegradation using rats as animal models. The film prepared using fibrin 10ml (40% solids) and chitosan solution 5ml (4% in 0.3N acetic acid) has exhibited better results. The FC films have shown excellent inhibition for bacterial penetration. The micrographs taken for wet membrane have shown swollen strands of fibrin expanding throughout the surface indicating the hydrogel nature of the film. In vivo degradation studies have revealed that the FC is completely biodegradable in 30 days without any adverse foreign body reaction indicating its biocompatibility.Keywords--Chitosan, fibrin, equilibrium water content (% EWC), water vapour transmission rate (WVTR), bacterial penetration, surface morphology, in vivo biodegradation

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Fungal mycelia as the source of chitin and polysaccharides and their applications as skin substitutes

Cited by 114 publications

References 14 publications

Preparation and evaluation of ciprofloxacin loaded chitosan-gelatin composite films for wound healing activity.

Preparation and evaluation of ciprofloxacin loaded chitosan-gelatin composite films for wound healing activity.

Sacchachitin, a novel chitin-polysaccharide conjugate macromolecule present inGanoderma lucidum: Purification, composition, and properties

Preparation and characterization of fibrin-chitosan composite and its in vivo studies

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