2015
DOI: 10.1371/journal.ppat.1004959
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Fungal Morphology, Iron Homeostasis, and Lipid Metabolism Regulated by a GATA Transcription Factor in Blastomyces dermatitidis

Abstract: In response to temperature, Blastomyces dermatitidis converts between yeast and mold forms. Knowledge of the mechanism(s) underlying this response to temperature remains limited. In B. dermatitidis, we identified a GATA transcription factor, SREB, important for the transition to mold. Null mutants (SREBΔ) fail to fully complete the conversion to mold and cannot properly regulate siderophore biosynthesis. To capture the transcriptional response regulated by SREB early in the phase transition (0–48 hours), gene … Show more

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Cited by 18 publications
(24 citation statements)
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“…Apart from the regulation of siderophore biosynthesis and iron metabolism, GATA TF SreA is also related with the maintenance of cell wall integrity and negatively impacts resistance as ΔsreA increases resistance to H 2 O 2 , calco uor white, and Congo red [10,14].The expression level of AoSreA was signi cantly downregulated under 40 ℃ and high salt stresses, which indicates AoSreA might negatively impact high-temperature and high salt resistance. In contrast, AoSreA was signi cantly upregulated at 22 ℃, and there is a report that the SreB strongly expresses and contributes to lamentous growth at 22 ℃ via lipid metabolism in Blastomyces dermatitidis [17]. AoSreA and SreB shared the same conserved ZnF_GATA domain ( Figure S2), which demonstrates that overexpression AoSreA in A. oryzae might also enhance the growth of mycelium at 22 ℃.…”
Section: Discussionmentioning
confidence: 86%
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“…Apart from the regulation of siderophore biosynthesis and iron metabolism, GATA TF SreA is also related with the maintenance of cell wall integrity and negatively impacts resistance as ΔsreA increases resistance to H 2 O 2 , calco uor white, and Congo red [10,14].The expression level of AoSreA was signi cantly downregulated under 40 ℃ and high salt stresses, which indicates AoSreA might negatively impact high-temperature and high salt resistance. In contrast, AoSreA was signi cantly upregulated at 22 ℃, and there is a report that the SreB strongly expresses and contributes to lamentous growth at 22 ℃ via lipid metabolism in Blastomyces dermatitidis [17]. AoSreA and SreB shared the same conserved ZnF_GATA domain ( Figure S2), which demonstrates that overexpression AoSreA in A. oryzae might also enhance the growth of mycelium at 22 ℃.…”
Section: Discussionmentioning
confidence: 86%
“…Fungal GATA TFs are mainly involved in the relation of nitrogen metabolism [12,31], light responses [13,29], siderophore biosynthesis and mating-type switching [10; 36]. Few GATA TFs in fungus also take part in response to the abiotic stresses, such as the SreA, SreB, LreA, LreB, GLN3 and GAT1 [10,13,17,18,29]. The number of the GATA TFs is conserved among A. clavatus, A. avus, A. fumigatus, A. nidulans, A. niger and A. oryaze that possess six GATA TFs, suggesting that lamentous fungi share an identical composition of GATA TFs with each other [26].…”
Section: Discussionmentioning
confidence: 99%
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“…Recent genetic analyses identified a GATA transcription factor encoded by SREB that mediates the conversion from yeast to mycelia after a drop in temperature from 37 to 22°C. 34 SREB null mutants (SREBΔ) exhibit a defect in the morphologic shift that corresponds to a reduction in neutral lipid (ergosterol, triacylglycerol) biosynthesis and lipid droplet formation. In B. dermatitidis and H. capsulatum, N -acetylglucosamine transporters NGT1 and NGT2 accelerate the transition to mycelia at 22°C.…”
Section: Pathogenesismentioning
confidence: 99%