“…Nevertheless, many organisms have demonstrated the ability to recover from extremely high doses of IR, such that could be expected to induce hundreds of DSBs within the genome (Zhdanova et al ., 2000; Liu et al ., 2003; Ingemar et al ., 2005; Rainey et al ., 2005; Dadachova and Casadevall, 2008; Gladyshev and Meselson, 2008; Vaisnav et al ., 2014; Pacelli et al ., 2017; Schultzhaus et al ., 2019, 2020). Fungi in particular have attracted interest due to their generally high resistance to acute IR exposure (Shuryak et al ., 2017; Schultzhaus et al ., 2019; Shuryak, 2019), their apparent increased abundance in environments that are highly contaminated with IR, such as Chernobyl (Zhdanova et al ., 2000) and Fukushima (Shinohara et al ., 2017, 2018), and their ability to sequester radionuclides (White and Gadd, 1990; Haselwandter and Berreck, 1994; Steiner et al ., 2002; Dighton, 2019). The development of budding yeast as a eukaryotic model has also provided a trove of information on IR recovery (Game and Mortimer, 1974; Benathen and Beam, 1977; Game, 1983; Bennett et al ., 2001), but a lack of studies in other species has meant that many fungalâspecific resistance mechanisms remain unknown.…”