Fungal keratitis caused by acremonium: A case report and literature review

Zbiba, W.; Kharrat, M.; Sayadi, Jihene; Baba, Akiko; Bouayed, E.; Abdessalem, N. Ben

doi:10.1016/j.jfo.2017.11.025

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…Zbiba et al . [ 16 ] have reported a rare case of Acremonium keratitis following windstorm exposure. The case was managed initially with topical and systemic voriconazole, followed by collagen crosslinking for stromal necrosis and finally a penetrating keratoplasty.…”

Section: Discussionmentioning

confidence: 99%

Acremonium keratitis: Risk factors, clinical characteristics, management, and outcome in 65 cases

Priyadarshini

Soni

Sahu

et al. 2022

Indian Journal of Ophthalmology

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Purpose: To study the risk factors, clinical presentation, management options, and outcomes in cases of culture-proven Acremonium keratitis. Methods: Medical and microbiology records of culture-proven Acremonium keratitis from Jan 2007 to Dec 2019 at a tertiary eye care center were reviewed. Details of clinical findings on each visit and operating notes were reviewed from the medical records. All cases were subjected to corneal scraping at the first visit for microbiological investigation consisting of direct smear examination and culture. Topical natamycin 5% was the mainstay of medical treatment. Surgical treatment was considered for nonresponding patients. Results: During the 13-year study period, 65 cases of culture-proven Acremonium keratitis were identified out of 1605 cases of fungal keratitis. Trauma was the most common predisposing factor in 32 cases (49.2%). The average area of the corneal stromal infiltrate was 24.8 mm 2 at the initial presentation. Hypopyon at the time of presentation was evident in 28 (43.1%) cases. Staphylococcus spp. was the most common ( n = 22, 33.8%) organism coexistent with Acremonium . Direct microscopy of corneal scraping was positive for fungal filaments in 57/65 (87.6%) cases. Medical management alone was given in 44 patients (67.6%). Age (>50 years) and treatment delay (>15 days) were found to be independent risk factors for the poor final visual outcome (VA <20/60). Conclusion: When treated early, Acremonium keratitis responds well to medical therapy with currently available topical antifungals. However, advanced and nonresponding cases require surgical intervention for resolution of the infection.

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Section: Discussionmentioning

confidence: 99%

Acremonium keratitis: Risk factors, clinical characteristics, management, and outcome in 65 cases

Priyadarshini

Soni

Sahu

et al. 2022

Indian Journal of Ophthalmology

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show abstract

“…[ 2 ] in four cases that were operated in the same operation room by different surgeons during the same period and even after exposure to a windstorm. [ 3 ] Post-herpetic keratitis fungal infection attributed to the Acremonium species has also been described. [ 4 ] Das et al .…”

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confidence: 99%