Fungal Invasion of Seven Hydrophilic Contact Lenses

Kirsch, Leonard S.; Brownstein, Seymour

doi:10.1016/s0002-9394(14)74447-2

Cited by 11 publications

(6 citation statements)

References 13 publications

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“…Fungal keratitis in association with contact lens wear is almost always due to Candida spp., although Cryptococcus laurentii (217) has been reported. Filamentous fungal keratitis occurs less often with lens wear (200,261,296), but the filamentous fungi can actually penetrate the lens matrix (141,200,245,261,289,296). Fungi and the bacteria adherent to contact lenses arise from patient handling, including the cleaning and storage of the lenses.…”

Section: Infections Of the Corneamentioning

confidence: 99%

Fungal and Parasitic Infections of the Eye

Klotz

Penn

Negvesky

et al. 2000

Clinical Microbiology Reviews

179

145

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Section: Infections Of the Corneamentioning

confidence: 99%

Fungal and Parasitic Infections of the Eye

Klotz

Penn

Negvesky

et al. 2000

Clinical Microbiology Reviews

179

145

View full text Add to dashboard Cite

Section: Infections Of the Corneamentioning

confidence: 99%

Fungal and Parasitic Infections of the Eye

et al. 2000

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SUMMARY The unique structure of the human eye as well as exposure of the eye directly to the environment renders it vulnerable to a number of uncommon infectious diseases caused by fungi and parasites. Host defenses directed against these microorganisms, once anatomical barriers are breached, are often insufficient to prevent loss of vision. Therefore, the timely identification and treatment of the involved microorganisms are paramount. The anatomy of the eye and its surrounding structures is presented with an emphasis upon the association of the anatomy with specific infection of fungi and parasites. For example, filamentous fungal infections of the eye are usually due to penetrating trauma by objects contaminated by vegetable matter of the cornea or globe or, by extension, of infection from adjacent paranasal sinuses. Fungal endophthalmitis and chorioretinitis, on the other hand, are usually the result of antecedent fungemia seeding the ocular tissue. Candida spp. are the most common cause of endogenous endophthalmitis, although initial infection with the dimorphic fungi may lead to infection and scarring of the chorioretina. Contact lens wear is associated with keratitis caused by yeasts, filamentous fungi, and Acanthamoebae spp. Most parasitic infections of the eye, however, arise following bloodborne carriage of the microorganism to the eye or adjacent structures.

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“…Fungal keratitis can occur among soft contact lenses wearers as a result of inappropriate cleaning or disinfecting procedures, fungal contamination of cleaning or preservation solutions for lenses, or due to microtrauma of the cornea resulting from continuous use of the lenses [2, 4–7]. In these cases the fungus can adhere to the surface of the contact lenses, invade the lenses, or into the cornea directly, facilitated by fungal enzymes [8–10], and cause keratitis.…”

Section: Introductionmentioning

confidence: 99%

Adherence of Aspergillus species to soft contact lenses and attempts to inhibit the adherence

Sionov

Sandovsky-Losica

Gov

et al. 2001

Mycoses

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The aim of this research was to assess the adherence of various Aspergillus species (A. niger, A. fumigatus, A. flavus) to contact lenses with different water content and to attempt to inhibit the adherence of Aspergillus spp. to the contact lenses by a chitin derivative (CSE). Adherence of Aspergillus spp. to lenses with higher water content was greater. Differences were found between the adherence levels of various Aspergillus species to contact lenses with different water content. CSE significantly inhibits the adherence in vitro of A. niger, A. fumigatus and A. flavus to soft contact lenses. These findings suggest a possibility for prevention of fungal ocular infections caused by Aspergillus spp. in wearers of contact lenses.

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Fungal Invasion of Seven Hydrophilic Contact Lenses

Cited by 11 publications

References 13 publications

Fungal and Parasitic Infections of the Eye

Fungal and Parasitic Infections of the Eye

Fungal and Parasitic Infections of the Eye

Adherence of Aspergillus species to soft contact lenses and attempts to inhibit the adherence

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