Fungal Infections (Onychomycosis, Tinea Pedis, Tinea Cruris, Tinea Capitis, Tinea Manuum, Tinea Corporis, different Candida Infections, and Pityriasis Versicolor) and Mycological Laboratory Analyses

Shemer, Avner; Babaev, Meir

doi:10.1007/978-3-319-72156-9_18

Cited by 6 publications

(18 citation statements)

References 41 publications

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“…Onychomycosis (tinea unguium) can occur in both sexes, but most studies have shown that onychomycosis is more common in men [ 58 ]. Nail lesions and thickened nails are more common in men than in women.…”

Section: Difference Of Sex and Gender Of The Human Host In Susceptibi...mentioning

confidence: 99%

“…One study showed better results with the use of the topical antifungal drug efinaconazole in women [ 59 ]. The incidence of tinea pedis increases with age and is higher in men than in women [ 58 ]. Men are affected about three times more frequently than women.…”

Section: Difference Of Sex and Gender Of The Human Host In Susceptibi...mentioning

confidence: 99%

“…This is probably due to different habits of wearing shoes (sports shoes or open shoes), foot hygiene, and occupational differences between the genders [ 58 ]. The fungus T. rubrum is the most common cause of tinea cruris, which is almost exclusively a male disease due to the moist environment created by contact between the scrotum and the skin of the groin [ 58 ]. Tinea cruris has also been found in female sex workers [ 58 ].…”

Section: Difference Of Sex and Gender Of The Human Host In Susceptibi...mentioning

confidence: 99%

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The Multifaceted Role of Mating Type of the Fungus and Sex of the Host in Studies of Fungal Infections in Humans

Kraševec

2022

JoF

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This review discusses the inclusion of sex and gender variables in studies of fungal infections in humans at the pathogen, host, and antifungal trial levels. The mating type of some fungi, or perhaps more likely the absence of the other, appears to be associated with some infections. Sexual and parasexual reproduction of some fungi is an important mechanism for the development of antifungal drug resistance. Host sex or gender influences the incidence of some infections such as aspergillosis, cryptococcosis, paracoccidioidomycosis, dermatophytosis, and candidiasis due to differences in immune response, behavior, and awareness for early detection and treatment. Participant sex (and age) is relevant not only in clinical antifungal trials but also in preclinical studies. The dimensions of sex and gender are important determinants throughout the fungal infection process and in approaches to prevent or treat these infections, as well as in development of antifungal drugs. Failure to consider sex and gender may be detrimental to the holistic understanding of the processes involved in fungal infection.

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Section: Difference Of Sex and Gender Of The Human Host In Susceptibi...mentioning

confidence: 99%

Section: Difference Of Sex and Gender Of The Human Host In Susceptibi...mentioning

confidence: 99%

Section: Difference Of Sex and Gender Of The Human Host In Susceptibi...mentioning

confidence: 99%

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The Multifaceted Role of Mating Type of the Fungus and Sex of the Host in Studies of Fungal Infections in Humans

Kraševec

2022

JoF

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“…Onychomycosis is responsible for 50 % of all nail dystrophies and affects about 10 % of the world population [3,4]. Its development predominates in diabetic patients, transplant patients, the elderly and HIV-positive individuals due to their lower immunological response [5][6][7][8][9]. Trichophyton rubrum is related to 80 % of the cases, followed by T. mentagrophytes, both being the main agents related to onychomycosis in humans [9,10].…”

Section: Introductionmentioning

confidence: 99%

“…Its development predominates in diabetic patients, transplant patients, the elderly and HIV-positive individuals due to their lower immunological response [5][6][7][8][9]. Trichophyton rubrum is related to 80 % of the cases, followed by T. mentagrophytes, both being the main agents related to onychomycosis in humans [9,10]. Microsporum species are less frequent in cases of onychomycosis, and are associated with a history of exposure to these organisms and the presence of risk factors by the patients [11,12].…”

Section: Introductionmentioning

confidence: 99%

Ex vivo potential of a quinoline-derivative nail lacquer as a new alternative for dermatophytic onychomycosis treatment

Machado

Pippi

Berlitz

et al. 2021

Journal of Medical Microbiology

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Introduction. Onychomycosis infections currently show a significant increase, affecting about 10 % of the world population. Trichophyton rubrum is the main agent responsible for about 80 % of the reported infections. The clinical cure for onychomycosis is extremely difficult and effective new antifungal therapy is needed. Hypothesis/Gap Statement. Ex vivo onychomycosis models using porcine hooves can be an excellent alternative for evaluating the efficacy of new anti-dermatophytic agents in a nail lacquer. Aim. Evaluation of the effectiveness of a nail lacquer containing a quinoline derivative on an ex vivo onychomycosis model using porcine hooves, as well as the proposal of a plausible antifungal mechanism of this derivative against dermatophytic strains. Methodology. The action mechanism of a quinoline derivative was evaluated through the sorbitol protection assay, exogenous ergosterol binding, and the determination of the dose-response curves by time-kill assay. Scanning electron microscopy evaluated the effect of the derivative in the fungal cells. The efficacy of a quinoline-derivative nail lacquer on an ex vivo onychomycosis model using porcine hooves was evaluated as well. Results. The quinoline derivative showed a time-dependent fungicidal effect, demonstrating reduction and damage in the morphology of dermatophytic hyphae. In addition, the ex vivo onychomycosis model was effective in the establishment of infection by T. rubrum. Conclusion. Treatment with the quinoline-derivative lacquer showed a significant inhibitory effect on T. rubrum strain in this infection model. Finally, the compound presents high potential for application in a formulation such as nail lacquer as a possible treatment for dermatophytic onychomycosis.

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Trends in Epidemiology of Dermatophytes in Iran

Gharaghani

Taghipour

Shamsizadeh

et al. 2021

Dermatophytes and Dermatophytoses

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Fungal Infections (Onychomycosis, Tinea Pedis, Tinea Cruris, Tinea Capitis, Tinea Manuum, Tinea Corporis, different Candida Infections, and Pityriasis Versicolor) and Mycological Laboratory Analyses

Cited by 6 publications

References 41 publications

The Multifaceted Role of Mating Type of the Fungus and Sex of the Host in Studies of Fungal Infections in Humans

The Multifaceted Role of Mating Type of the Fungus and Sex of the Host in Studies of Fungal Infections in Humans

Ex vivo potential of a quinoline-derivative nail lacquer as a new alternative for dermatophytic onychomycosis treatment

Trends in Epidemiology of Dermatophytes in Iran

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