Fungal Infections in Newborn

Abstract

Sistemik fungal enfeksiyonlar yenidoğan bebeklerde, özellikle aşırı düşük doğum ağırlıklı prematürelerde yüksek mortalite ve morbidite oranlarına sahiptir. Prematüre bebekler, uzun süre parenteral beslenme, çoklu antibiyotik tedavileri, prematüriteden kaynaklanan bağışıklık yetmezliği nedeniyle fungal enfeksiyonlar için risk altındadırlar. Teknolojik gelişimle prematüre bebeklerin yaşam sınırının daha düşük gestasyon haftalarına çekilmesi sonucunda, yenidoğan yoğun bakım ünitelerinde invaziv girişimlerin, santral kateterlerin ve antibiyotiklerin kullanımı artmıştır. Tüm bu faktörler fungal enfeksiyon oranlarında artışı da beraberinde getirmiştir. Bu yazıda, yenidoğan döneminde görülebi-len fungal enfeksiyonların klinik ve tanısal özellikleri, güncel literatür bilgileri eşliğinde derlenmiştir. AbstractSystemic fungal infections have high mortality and morbidity rates in neonates, especially in extremely low birth weight premature infants. Because of longterm parenteral nutrition, multiple antibiotic therapy and immune deficiency due to prematurity, premature babies are at risk for fungal infections. With emerging technologies viability border in premature infants is drawn lower gestational ages and increased use of antibiotics, invasive procedures and central catheters have brought an increase in fungal infection rates. In this article, the clinical and diagnostic features of fungal infections which can be seen during the neonatal period, was reviewed and compiled with the current literature. (J Pediatr Inf 2016; 10: 143-50)

Candidal Infections in the Neonatal Intensive Care Unit: A Retrospective Observational Study

“…Candida infections are the most common fungal infections in the neonatal period, especially in very low birth weight infants, with high morbidity and mortality rates. [ 8 ] It has been reported that Candida infections are responsible for 1.4% of the early neonatal sepsis and 2.6%–16.7% of late-onset sepsis in very low birth weight infants. [ 8 ] In a study examining single-center nosocomial infections, they found 61.9% Gram-positive bacteria, 30.9% Gram-negative bacteria, and 7.2% fungi.…”

“…[ 8 ] It has been reported that Candida infections are responsible for 1.4% of the early neonatal sepsis and 2.6%–16.7% of late-onset sepsis in very low birth weight infants. [ 8 ] In a study examining single-center nosocomial infections, they found 61.9% Gram-positive bacteria, 30.9% Gram-negative bacteria, and 7.2% fungi. [ 9 ] This rate has been reported to vary between 1.1% and 1.3% in studies in Europe [ 1 ] , and 4–7.7% in Asia.…”