Fungal infections in lung transplantation

Samanta, Palash; Clancy, Cornelius J.; Nguyen, M.H.

doi:10.21037/jtd-2021-26

Cited by 17 publications

(23 citation statements)

References 61 publications

(114 reference statements)

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“…The long-term survival rates of LTRs remain poor because of CLAD and infections [ 7 ], as about 35% of LTRs still die within 1 year after LT [ 8 ]. Preventive antimicrobial prophylaxis is very important to reduce the incidence of bacterial, viral, and fungal infections after LT [ 7 - 11 ].…”

Section: Pulmonary Complicationsmentioning

confidence: 99%

Medical Complications of Lung Transplantation

Park

2022

J Chest Surg

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Lung transplantation (LT) is now considered as an effective treatment option for end-stage lung diseases that improves the short and long-term survival rates and quality of life. As increasingly many LT procedures are being performed, the medical complications of LT are also increasing in frequency and emerging as a very important issue for transplant clinicians. Although chronic lung allograft dysfunction and infection are major causes of death after LT, many medical complications, several of which result from immunosuppressive treatment, contribute to increased mortality and morbidity. This article reviews the most frequent and important medical complications of LT, accompanied by a review of the literature and studies from South Korea, including lung allograft rejection, infection, and non-allograft organ systemic complications.

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Section: Pulmonary Complicationsmentioning

confidence: 99%

Medical Complications of Lung Transplantation

Park

2022

J Chest Surg

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“…Ever since the first successful lung transplant in 1983 [ 58 ], the number of lung transplants occurring each year has increased. In the year 2019, in USA alone, a total of 2714 lung transplants was performed, with a 7.3% increase from 2018 [ 59 ]. The first successful lung transplant in India was conducted in 1999[ 58 ], and 266 transplants were performed in 2021 [ 1 ].…”

Section: Ifi In Sot: India Vs the Worldmentioning

confidence: 99%

Epidemiology of Invasive Fungal Infections in Solid Organ Transplant Recipients: an Indian Perspective

Sharma

Rudramurthy

Chakrabarti³

2022

Curr Fungal Infect Rep

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Purpose of Review This review summarizes the available Indian data on epidemiology of invasive fungal infections (IFI) in recipients of solid organ transplants (SOT). The epidemiology is further compared with studies from other parts of the world for each SOT type. Recent Findings The available studies on Indian epidemiology of IFI in SOT are scarce, though the number of SOTs performed in India have increased tremendously in recent years. The limited data from India present a distinct spectrum of infection in transplant recipients with high incidence of mucormycosis. During COVID-19 outbreak, IFI rate increased and renal transplant recipients acquired mucormycosis earlier than previous studies. Summary Maximum data on IFI was available from renal transplant recipients, wherein mucormycosis was the predominant IFI in Indian patients in contrast to invasive candidiasis in majority countries. The other IFIs had varied spectrum. With the increasing number of SOTs being performed and the already persisting high burden of IFI in India, there is an urgent need of larger prospective studies on epidemiology of IFI in transplant recipients.

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“…Worldwide, fungal infections have been associated with approximately 1.5 million deaths per year [ 2 , 3 ]. An increase in the size of the immunocompromised population including people receiving chemotherapy, those infected with human immunodeficiency virus (HIV) or SARS-CoV-2, and the elderly has led to a significant increase in the prevalence of invasive fungal infections [ 4 , 5 , 6 , 7 ]. Among fungi, Candida species are the most frequently isolated opportunistic fungal pathogens, causing morbidity and mortality in patients.…”

Section: Introductionmentioning

confidence: 99%

Distribution of Yeast Species and Risk Factors of Oral Colonization after Oral-Care Education among the Residents of Nursing Homes

Lin

Chiang

et al. 2022

JoF

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Most yeasts causing infections in humans are part of commensal microflora and etiological agents of different infections when hosts become susceptible, usually due to becoming immunocompromised. The colonization of potentially pathogenic microbes in the oral cavity is increased by poor oral hygiene. This follow-up survey was conducted approximately two months after providing information on proper oral care at 10 nursing homes in Taiwan. Among the 117 of 165 residents colonized by yeasts, 67 were colonized by more than one yeast species. A total of 231 isolates comprising eight fungal genera and 25 species were identified. Candida albicans (44.6%) was the dominant species, followed by Candida glabrata (17.7%), Candida parapsilosis (8.7%), Candida tropicalis (7.8%), and Candida pararugosa (7.3%). Residents having a yeast colony-forming unit >10 (OR, 8.897; 95% CI 2.972–26.634; p < 0.001) or using a wheelchair (OR, 4.682; 95% CI 1.599–13.705; p = 0.005) were more likely to be colonized by multiple species. By comparing before and after oral-care education, dry mouth (OR, 3.199; 95% CI 1.448–7.068; p = 0.011) and having heart disease (OR, 2.681; 95% CI 1.068–6.732; p = 0.036) emerged as two independent risk factors for increased density of colonizing yeast.

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Fungal infections in lung transplantation

Cited by 17 publications

References 61 publications

Medical Complications of Lung Transplantation

Medical Complications of Lung Transplantation

Epidemiology of Invasive Fungal Infections in Solid Organ Transplant Recipients: an Indian Perspective

Distribution of Yeast Species and Risk Factors of Oral Colonization after Oral-Care Education among the Residents of Nursing Homes

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