2018
DOI: 10.1371/journal.pone.0190543
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Fungal genotype determines survival of Drosophila melanogaster when competing with Aspergillus nidulans

Abstract: Fungi produce an astonishing variety of secondary metabolites, some of which belong to the most toxic compounds in the living world. Several fungal metabolites have anti-insecticidal properties which may yield advantages to the fungus in competition with insects for exploitation of environmental resources. Using the Drosophila melanogaster/Aspergillus nidulans ecological model system to assess secondary metabolite mutant genotypes, we find a major role for the veA allele in insect/fungal confrontations that ex… Show more

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Cited by 8 publications
(7 citation statements)
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“…Non-aflatoxigenic knockout and low toxin-producing strains of Aspergillus are less capable of antagonizing insect populations (Regulin and Kempken, 2018). In addition to balancing selection on mycotoxin production, it must be noted that insect adaptation to mold competition seems to favor tolerance instead of resistance (Trienens and Rohlfs, 2011).…”
Section: The Aspergilli and Their Mycotoxins Versus Arthropodsmentioning
confidence: 99%
“…Non-aflatoxigenic knockout and low toxin-producing strains of Aspergillus are less capable of antagonizing insect populations (Regulin and Kempken, 2018). In addition to balancing selection on mycotoxin production, it must be noted that insect adaptation to mold competition seems to favor tolerance instead of resistance (Trienens and Rohlfs, 2011).…”
Section: The Aspergilli and Their Mycotoxins Versus Arthropodsmentioning
confidence: 99%
“…Several model organisms have been adopted for studying of dimorphic and filamentous pathogenic fungi, including invertebrate models such as Drosophila melanogaster (Lamaris et al, 2008;Regulin and Kempken, 2018;Sampaio et al, 2018;Wurster et al, 2019), Galleria mellonella (Gomez-Lopez et al, 2014;Long et al, 2018;Silva et al, 2018;Staniszewska et al, 2020), Bombyx mori (Matsumoto et al, 2013;Uchida et al, 2016;Nakamura et al, 2017;Matsumoto and Sekimizu, 2019), Caenorhabditis elegans (Okoli and Bignell, 2015;Song et al, 2019;Wong et al, 2019;Ahamefule et al, 2020a), and vertebrate models such as mice (Fakhim et al, 2018;Skalski et al, 2018;Wang et al, 2018;Mueller et al, 2019), guinea pigs (Vallor et al, 2008;Nadaşet al, 2013;Garvey et al, 2015), and zebrafish (Chen et al, 2015;Knox et al, 2017;Koch et al, 2019;Kulatunga et al, 2019).…”
Section: Introductionmentioning
confidence: 99%
“…Why was the synthesis of the pigment not stimulated by grazing? The likely reason was that as in most studies of interactions between A. nidulans and arthropods conducted thus far, in this study, an A. nidulans strain carrying mutation veA1 was used, which is defective in secondary metabolite production and defence responses 38 . VeA is part of the velvet complex, which is needed for aurofusarin synthesis in F. graminearum 39 .…”
Section: Discussionmentioning
confidence: 99%