Fungal feelings in the irritable bowel syndrome: the intestinal mycobiome and abdominal pain

Thiel, I Van; Jonge, W de; Wijngaard, René M van den

doi:10.1080/19490976.2023.2168992

Cited by 8 publications

(4 citation statements)

References 106 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This issue remains a challenge, especially in samples from patients with diarrhea. Finally, most publications have focused on bacteria, but the mycobiome deserves attention in gut disorders including IBS [66].…”

Section: Discussionmentioning

confidence: 99%

Fecal Microbial Composition and Predicted Functional Profile in Irritable Bowel Syndrome Differ between Subtypes and Geographical Locations

Garcia-Mazcorro,

Amieva-Balmori,

Triana-Romero

et al. 2023

Microorganisms

View full text Add to dashboard Cite

Increasing evidence suggests a microbial pathogenesis in irritable bowel syndrome (IBS) but the relationship remains elusive. Fecal DNA samples from 120 patients with IBS, 82 Mexican (IBS-C: n = 33, IBS-D: n = 24, IBS-M: n = 25) and 38 British (IBS-C: n = 6, IBS-D: n = 27, IBS-M: n = 5), were available for analysis using 16S rRNA gene sequencing. Firmicutes (mean: 82.1%), Actinobacteria (10.2%), and Bacteroidetes (4.4%) were the most abundant taxa. The analysis of all samples (n = 120), and females (n = 94) only, showed no significant differences in bacterial microbiota, but the analysis of Mexican patients (n = 82) showed several differences in key taxa (e.g., Faecalibacterium) among the different IBS subtypes. In IBS-D there were significantly higher Bacteroidetes in British patients (n = 27) than in Mexican patients (n = 24), suggesting unique fecal microbiota signatures within the same IBS subtype. These differences in IBS-D were also observed at lower phylogenetic levels (e.g., higher Enterobacteriaceae and Streptococcus in Mexican patients) and were accompanied by differences in several alpha diversity metrics. Beta diversity was not different among IBS subtypes when using all samples, but the analysis of IBS-D patients revealed consistent differences between Mexican and British patients. This study suggests that fecal microbiota is different between IBS subtypes and also within each subtype depending on geographical location.

show abstract

Section: Discussionmentioning

confidence: 99%

Fecal Microbial Composition and Predicted Functional Profile in Irritable Bowel Syndrome Differ between Subtypes and Geographical Locations

Garcia-Mazcorro,

Amieva-Balmori,

Triana-Romero

et al. 2023

Microorganisms

View full text Add to dashboard Cite

show abstract

“…While it has been shown that both the mycobiome 167 , 168 and the virome 169–171 are altered in IBS patients, and may play an important, yet under-investigated role, it is still very difficult to disentangle the fluctuations of these populations from those of the bacterial microbiome. 168 Interestingly, a recent multi-omics study found the virome to be temporally stable and not affected by symptomatic flares in IBS patients but to vary among subsets of IBS patients.…”

Section: The Role Of Gut Microbiota In Dgbimentioning

confidence: 99%

“… 171 , 172 As for the mycobiome, it has been shown that Candida albicans species abundance is increased in IBS, and that specific C. albicans strains may aid in distinguishing subsets of IBS patients. 167 However, larger studies that investigate further the role of both gut virome and mycobiome in relation to host and gut bacterial communities are needed.…”

Section: The Role Of Gut Microbiota In Dgbimentioning

confidence: 99%

The gut microbiome in disorders of gut–brain interaction

Kraimi,

Ross,

Pujo

et al. 2024

Gut Microbes

View full text Add to dashboard Cite

“…Caminero et al 8 raise the role of bacterial proteolytic imbalance as a new player in the modulation of inflammation, barrier function and pain, postulating a new class of drug development that targets this activity could help restore protease balance and alleviate disease. Van Thiel et al 9 remind us that while the bacteriome has been mostly studied in relation to pain, the intestinal mycobiome is emerging as an important player in a subset of IBS hypersensitive patients. Interestingly, their results showed that the visceral hypersensitivity phenotype could be transferred to animal models through fecal transfer and rescued by fungicide treatment.…”

mentioning

confidence: 99%